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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Smc4
Full Name:
Structural maintenance of chromosomes protein 4
Alias:
CAPC; CAP-C; Chromosome- associated polypeptide C; Chromosome-associated polypeptide C; HCAP-C; SMC4L1; Structural maintenance of chromosomes 4; Structural maintenance of chromosomes 4-like 1 protein; XCAP-C homolog
Type:
Cell cycle regulation
Mass (Da):
147182
Number AA:
1288
UniProt ID:
Q9NTJ3
International Prot ID:
IPI00411559
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000796
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0046982
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007076
GO:0006323
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
P
R
K
G
T
Q
P
S
T
A
R
R
Site 2
S9
P
R
K
G
T
Q
P
S
T
A
R
R
R
E
E
Site 3
T10
R
K
G
T
Q
P
S
T
A
R
R
R
E
E
G
Site 4
S22
P
S
P
D
G
A
S
S
D
A
E
P
E
P
P
Site 5
S27
P
P
S
P
D
G
A
S
S
D
A
E
P
E
P
Site 6
S28
E
E
G
P
P
P
P
S
P
D
G
A
S
S
D
Site 7
S36
D
A
E
P
E
P
P
S
G
R
T
E
S
P
A
Site 8
T39
P
E
P
P
S
G
R
T
E
S
P
A
T
A
A
Site 9
S41
P
P
S
G
R
T
E
S
P
A
T
A
A
E
T
Site 10
T44
G
R
T
E
S
P
A
T
A
A
E
T
A
S
E
Site 11
T48
S
P
A
T
A
A
E
T
A
S
E
E
L
D
N
Site 12
S50
A
T
A
A
E
T
A
S
E
E
L
D
N
R
S
Site 13
S57
S
E
E
L
D
N
R
S
L
E
E
I
L
N
S
Site 14
S64
S
L
E
E
I
L
N
S
I
P
P
P
P
P
P
Site 15
T85
G
A
P
R
L
M
I
T
H
I
V
N
Q
N
F
Site 16
S94
I
V
N
Q
N
F
K
S
Y
A
G
E
K
I
L
Site 17
S117
C
I
I
G
P
N
G
S
G
K
S
N
V
I
D
Site 18
S120
G
P
N
G
S
G
K
S
N
V
I
D
S
M
L
Site 19
Y132
S
M
L
F
V
F
G
Y
R
A
Q
K
I
R
S
Site 20
S139
Y
R
A
Q
K
I
R
S
K
K
L
S
V
L
I
Site 21
S143
K
I
R
S
K
K
L
S
V
L
I
H
N
S
D
Site 22
S149
L
S
V
L
I
H
N
S
D
E
H
K
D
I
Q
Site 23
T159
H
K
D
I
Q
S
C
T
V
E
V
H
F
Q
K
Site 24
Y175
I
D
K
E
G
D
D
Y
E
V
I
P
N
S
N
Site 25
Y184
V
I
P
N
S
N
F
Y
V
S
R
T
A
C
R
Site 26
T188
S
N
F
Y
V
S
R
T
A
C
R
D
N
T
S
Site 27
T194
R
T
A
C
R
D
N
T
S
V
Y
H
I
S
G
Site 28
S195
T
A
C
R
D
N
T
S
V
Y
H
I
S
G
K
Site 29
Y197
C
R
D
N
T
S
V
Y
H
I
S
G
K
K
K
Site 30
S200
N
T
S
V
Y
H
I
S
G
K
K
K
T
F
K
Site 31
T205
H
I
S
G
K
K
K
T
F
K
D
V
G
N
L
Site 32
S215
D
V
G
N
L
L
R
S
H
G
I
D
L
D
H
Site 33
Y253
H
D
E
G
M
L
E
Y
L
E
D
I
I
G
C
Site 34
Y325
K
K
N
H
V
C
Q
Y
Y
I
Y
E
L
Q
K
Site 35
Y326
K
N
H
V
C
Q
Y
Y
I
Y
E
L
Q
K
R
Site 36
S355
T
K
E
I
N
E
K
S
N
I
L
S
N
E
M
Site 37
S359
N
E
K
S
N
I
L
S
N
E
M
K
A
K
N
Site 38
S409
E
K
L
K
H
A
T
S
K
A
K
K
L
E
K
Site 39
S430
E
K
V
E
E
F
K
S
I
P
A
K
S
N
N
Site 40
S435
F
K
S
I
P
A
K
S
N
N
I
I
N
E
T
Site 41
S466
K
L
K
E
V
M
D
S
L
K
Q
E
T
Q
G
Site 42
S489
E
K
E
L
M
G
F
S
K
S
V
N
E
A
R
Site 43
S491
E
L
M
G
F
S
K
S
V
N
E
A
R
S
K
Site 44
S504
S
K
M
D
V
A
Q
S
E
L
D
I
Y
L
S
Site 45
Y509
A
Q
S
E
L
D
I
Y
L
S
R
H
N
T
A
Site 46
S511
S
E
L
D
I
Y
L
S
R
H
N
T
A
V
S
Site 47
T515
I
Y
L
S
R
H
N
T
A
V
S
Q
L
T
K
Site 48
S518
S
R
H
N
T
A
V
S
Q
L
T
K
A
K
E
Site 49
S574
Q
E
E
T
N
F
K
S
L
V
H
D
L
F
Q
Site 50
S588
Q
K
V
E
E
A
K
S
S
L
A
M
N
R
S
Site 51
S589
K
V
E
E
A
K
S
S
L
A
M
N
R
S
R
Site 52
S595
S
S
L
A
M
N
R
S
R
G
K
V
L
D
A
Site 53
S609
A
I
I
Q
E
K
K
S
G
R
I
P
G
I
Y
Site 54
Y616
S
G
R
I
P
G
I
Y
G
R
L
G
D
L
G
Site 55
T682
A
V
W
A
K
K
M
T
E
I
Q
T
P
E
N
Site 56
T686
K
K
M
T
E
I
Q
T
P
E
N
T
P
R
L
Site 57
T690
E
I
Q
T
P
E
N
T
P
R
L
F
D
L
V
Site 58
Y709
E
K
I
R
Q
A
F
Y
F
A
L
R
D
T
L
Site 59
Y729
D
Q
A
T
R
V
A
Y
Q
K
D
R
R
W
R
Site 60
T739
D
R
R
W
R
V
V
T
L
Q
G
Q
I
I
E
Site 61
S748
Q
G
Q
I
I
E
Q
S
G
T
M
T
G
G
G
Site 62
T750
Q
I
I
E
Q
S
G
T
M
T
G
G
G
S
K
Site 63
T752
I
E
Q
S
G
T
M
T
G
G
G
S
K
V
M
Site 64
S756
G
T
M
T
G
G
G
S
K
V
M
K
G
R
M
Site 65
S766
M
K
G
R
M
G
S
S
L
V
I
E
I
S
E
Site 66
S772
S
S
L
V
I
E
I
S
E
E
E
V
N
K
M
Site 67
S781
E
E
V
N
K
M
E
S
Q
L
Q
N
D
S
K
Site 68
S810
R
V
V
K
L
R
H
S
E
R
E
M
R
N
T
Site 69
T817
S
E
R
E
M
R
N
T
L
E
K
F
T
A
S
Site 70
Y834
R
L
I
E
Q
E
E
Y
L
N
V
Q
V
K
E
Site 71
S864
K
L
L
E
E
N
V
S
A
F
K
T
E
Y
D
Site 72
T868
E
N
V
S
A
F
K
T
E
Y
D
A
V
A
E
Site 73
Y870
V
S
A
F
K
T
E
Y
D
A
V
A
E
K
A
Site 74
S918
K
Q
L
D
E
C
A
S
A
I
T
K
A
Q
V
Site 75
T929
K
A
Q
V
A
I
K
T
A
D
R
N
L
Q
K
Site 76
S940
N
L
Q
K
A
Q
D
S
V
L
R
T
E
K
E
Site 77
T944
A
Q
D
S
V
L
R
T
E
K
E
I
K
D
T
Site 78
T951
T
E
K
E
I
K
D
T
E
K
E
V
D
D
L
Site 79
T959
E
K
E
V
D
D
L
T
A
E
L
K
S
L
E
Site 80
S964
D
L
T
A
E
L
K
S
L
E
D
K
A
A
E
Site 81
S982
N
T
N
A
A
E
E
S
L
P
E
I
Q
K
E
Site 82
S1013
A
L
Q
K
D
A
L
S
I
K
L
K
L
E
Q
Site 83
Y1034
E
H
N
S
K
I
K
Y
W
H
K
E
I
S
K
Site 84
S1043
H
K
E
I
S
K
I
S
L
H
P
I
E
D
N
Site 85
S1056
D
N
P
I
E
E
I
S
V
L
S
P
E
D
L
Site 86
S1071
E
A
I
K
N
P
D
S
I
T
N
Q
I
A
L
Site 87
Y1103
Y
K
K
K
E
E
L
Y
L
Q
R
V
A
E
L
Site 88
T1114
V
A
E
L
D
K
I
T
Y
E
R
D
S
F
R
Site 89
Y1115
A
E
L
D
K
I
T
Y
E
R
D
S
F
R
Q
Site 90
S1119
K
I
T
Y
E
R
D
S
F
R
Q
A
Y
E
D
Site 91
Y1124
R
D
S
F
R
Q
A
Y
E
D
L
R
K
Q
R
Site 92
S1166
A
E
L
E
L
V
D
S
L
D
P
F
S
E
G
Site 93
S1177
F
S
E
G
I
M
F
S
V
R
P
P
K
K
S
Site 94
S1184
S
V
R
P
P
K
K
S
W
K
K
I
F
N
L
Site 95
S1192
W
K
K
I
F
N
L
S
G
G
E
K
T
L
S
Site 96
T1213
A
L
H
H
Y
K
P
T
P
L
Y
F
M
D
E
Site 97
Y1216
H
Y
K
P
T
P
L
Y
F
M
D
E
I
D
A
Site 98
Y1238
S
I
V
A
F
Y
I
Y
E
Q
T
K
N
A
Q
Site 99
Y1266
S
D
R
L
I
G
I
Y
K
T
Y
N
I
T
K
Site 100
T1268
R
L
I
G
I
Y
K
T
Y
N
I
T
K
S
V
Site 101
S1274
K
T
Y
N
I
T
K
S
V
A
V
N
P
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation