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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMEM106B
Full Name:
Transmembrane protein 106B
Alias:
MGC33727; T106B
Type:
Membrane protein
Mass (Da):
31127
Number AA:
274
UniProt ID:
Q9NUM4
International Prot ID:
IPI00395903
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0016021
GO:0031224
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
G
K
S
L
S
H
L
P
L
H
Site 2
S6
_
_
M
G
K
S
L
S
H
L
P
L
H
S
S
Site 3
S13
S
H
L
P
L
H
S
S
K
E
D
A
Y
D
G
Site 4
Y18
H
S
S
K
E
D
A
Y
D
G
V
T
S
E
N
Site 5
S33
M
R
N
G
L
V
N
S
E
V
H
N
E
D
G
Site 6
S46
D
G
R
N
G
D
V
S
Q
F
P
Y
V
E
F
Site 7
Y50
G
D
V
S
Q
F
P
Y
V
E
F
T
G
R
D
Site 8
T54
Q
F
P
Y
V
E
F
T
G
R
D
S
V
T
C
Site 9
S58
V
E
F
T
G
R
D
S
V
T
C
P
T
C
Q
Site 10
T60
F
T
G
R
D
S
V
T
C
P
T
C
Q
G
T
Site 11
Y84
Q
L
V
A
L
I
P
Y
S
D
Q
R
L
R
P
Site 12
S85
L
V
A
L
I
P
Y
S
D
Q
R
L
R
P
R
Site 13
T94
Q
R
L
R
P
R
R
T
K
L
Y
V
M
A
S
Site 14
Y97
R
P
R
R
T
K
L
Y
V
M
A
S
V
F
V
Site 15
Y125
P
R
S
I
D
V
K
Y
I
G
V
K
S
A
Y
Site 16
Y132
Y
I
G
V
K
S
A
Y
V
S
Y
D
V
Q
K
Site 17
S134
G
V
K
S
A
Y
V
S
Y
D
V
Q
K
R
T
Site 18
Y135
V
K
S
A
Y
V
S
Y
D
V
Q
K
R
T
I
Site 19
Y143
D
V
Q
K
R
T
I
Y
L
N
I
T
N
T
L
Site 20
Y157
L
N
I
T
N
N
N
Y
Y
S
V
E
V
E
N
Site 21
T198
D
M
K
Q
I
D
Y
T
V
P
T
V
I
A
E
Site 22
Y236
Q
V
T
V
T
T
T
Y
F
G
H
S
E
Q
I
Site 23
S244
F
G
H
S
E
Q
I
S
Q
E
R
Y
Q
Y
V
Site 24
Y248
E
Q
I
S
Q
E
R
Y
Q
Y
V
D
C
G
R
Site 25
Y250
I
S
Q
E
R
Y
Q
Y
V
D
C
G
R
N
T
Site 26
T258
V
D
C
G
R
N
T
T
Y
Q
L
G
Q
S
E
Site 27
Y259
D
C
G
R
N
T
T
Y
Q
L
G
Q
S
E
Y
Site 28
Y266
Y
Q
L
G
Q
S
E
Y
L
N
V
L
Q
P
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation