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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPTLC3
Full Name:
Serine palmitoyltransferase 3
Alias:
C20orf38; SPTLC2L
Type:
Endoplasmic reticulum, Membrane protein
Mass (Da):
62049
Number AA:
552
UniProt ID:
Q9NUV7
International Prot ID:
IPI00019565
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0017059
Uniprot
OncoNet
Molecular Function:
GO:0030170
GO:0004758
GO:0016769
PhosphoSite+
KinaseNET
Biological Process:
GO:0030148
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
H
K
K
Q
S
N
G
S
Q
S
R
N
C
T
K
Site 2
T30
G
S
Q
S
R
N
C
T
K
N
G
I
V
K
E
Site 3
S54
Y
D
K
L
I
V
E
S
F
E
E
A
P
L
H
Site 4
Y107
Q
K
D
F
V
P
L
Y
Q
D
F
E
N
F
Y
Site 5
Y114
Y
Q
D
F
E
N
F
Y
T
R
N
L
Y
M
R
Site 6
Y119
N
F
Y
T
R
N
L
Y
M
R
I
R
D
N
W
Site 7
Y148
M
E
R
V
S
D
D
Y
N
W
T
F
R
F
T
Site 8
S180
L
A
A
K
Y
D
E
S
M
R
T
I
K
D
V
Site 9
T183
K
Y
D
E
S
M
R
T
I
K
D
V
L
E
V
Site 10
T193
D
V
L
E
V
Y
G
T
G
V
A
S
T
R
H
Site 11
S197
V
Y
G
T
G
V
A
S
T
R
H
E
M
G
T
Site 12
T204
S
T
R
H
E
M
G
T
L
D
K
H
K
E
L
Site 13
S250
G
K
G
C
L
I
L
S
D
E
L
N
H
T
S
Site 14
T256
L
S
D
E
L
N
H
T
S
L
V
L
G
A
R
Site 15
T268
G
A
R
L
S
G
A
T
I
R
I
F
K
H
N
Site 16
S279
F
K
H
N
N
T
Q
S
L
E
K
L
L
R
D
Site 17
Y290
L
L
R
D
A
V
I
Y
G
Q
P
R
T
R
R
Site 18
T295
V
I
Y
G
Q
P
R
T
R
R
A
W
K
K
I
Site 19
Y334
K
K
Y
K
A
Y
L
Y
I
D
E
A
H
S
I
Site 20
S340
L
Y
I
D
E
A
H
S
I
G
A
V
G
P
T
Site 21
T352
G
P
T
G
R
G
V
T
E
F
F
G
L
D
P
Site 22
S376
F
T
K
S
F
G
A
S
G
G
Y
I
A
G
R
Site 23
Y379
S
F
G
A
S
G
G
Y
I
A
G
R
K
D
L
Site 24
Y389
G
R
K
D
L
V
D
Y
L
R
V
H
S
H
S
Site 25
S394
V
D
Y
L
R
V
H
S
H
S
A
V
Y
A
S
Site 26
S396
Y
L
R
V
H
S
H
S
A
V
Y
A
S
S
M
Site 27
S401
S
H
S
A
V
Y
A
S
S
M
S
P
P
I
A
Site 28
S402
H
S
A
V
Y
A
S
S
M
S
P
P
I
A
E
Site 29
Y440
Q
L
A
K
N
T
R
Y
F
R
Q
R
L
Q
E
Site 30
T515
H
T
R
E
M
L
D
T
V
L
E
A
L
D
E
Site 31
Y531
G
D
L
L
Q
L
K
Y
S
R
H
K
K
S
A
Site 32
S532
D
L
L
Q
L
K
Y
S
R
H
K
K
S
A
R
Site 33
S537
K
Y
S
R
H
K
K
S
A
R
P
E
L
Y
D
Site 34
Y543
K
S
A
R
P
E
L
Y
D
E
T
S
F
E
L
Site 35
S547
P
E
L
Y
D
E
T
S
F
E
L
E
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation