KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TDP1
Full Name:
Tyrosyl-DNA phosphodiesterase 1
Alias:
FLJ11090; SCAN1; TYDP1
Type:
EC 3.1.4.-; Phosphodiesterase; DNA repair
Mass (Da):
68420
Number AA:
608
UniProt ID:
Q9NUW8
International Prot ID:
IPI00655885
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0017005
GO:0003690
GO:0004527
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0006302
GO:0000012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
S
Q
E
G
D
Y
G
R
W
T
I
S
S
Site 2
T11
E
G
D
Y
G
R
W
T
I
S
S
S
D
E
S
Site 3
S13
D
Y
G
R
W
T
I
S
S
S
D
E
S
E
E
Site 4
S14
Y
G
R
W
T
I
S
S
S
D
E
S
E
E
E
Site 5
S15
G
R
W
T
I
S
S
S
D
E
S
E
E
E
K
Site 6
S18
T
I
S
S
S
D
E
S
E
E
E
K
P
K
P
Site 7
S29
K
P
K
P
D
K
P
S
T
S
S
L
L
C
A
Site 8
T30
P
K
P
D
K
P
S
T
S
S
L
L
C
A
R
Site 9
S32
P
D
K
P
S
T
S
S
L
L
C
A
R
Q
G
Site 10
Y46
G
A
A
N
E
P
R
Y
T
C
S
E
A
Q
K
Site 11
T47
A
A
N
E
P
R
Y
T
C
S
E
A
Q
K
A
Site 12
S61
A
A
H
K
R
K
I
S
P
V
K
F
S
N
T
Site 13
S66
K
I
S
P
V
K
F
S
N
T
D
S
V
L
P
Site 14
T68
S
P
V
K
F
S
N
T
D
S
V
L
P
P
K
Site 15
S70
V
K
F
S
N
T
D
S
V
L
P
P
K
R
Q
Site 16
S79
L
P
P
K
R
Q
K
S
G
S
Q
E
D
L
G
Site 17
S81
P
K
R
Q
K
S
G
S
Q
E
D
L
G
W
C
Site 18
S90
E
D
L
G
W
C
L
S
S
S
D
D
E
L
Q
Site 19
S91
D
L
G
W
C
L
S
S
S
D
D
E
L
Q
P
Site 20
S92
L
G
W
C
L
S
S
S
D
D
E
L
Q
P
E
Site 21
S117
I
K
K
E
K
D
I
S
A
P
N
D
G
T
A
Site 22
Y145
L
K
E
E
E
D
E
Y
E
T
S
G
E
G
Q
Site 23
T147
E
E
E
D
E
Y
E
T
S
G
E
G
Q
D
I
Site 24
S148
E
E
D
E
Y
E
T
S
G
E
G
Q
D
I
W
Site 25
Y167
K
G
N
P
F
Q
F
Y
L
T
R
V
S
G
V
Site 26
S172
Q
F
Y
L
T
R
V
S
G
V
K
P
K
Y
N
Site 27
Y178
V
S
G
V
K
P
K
Y
N
S
G
A
L
H
I
Site 28
Y215
V
D
W
L
V
K
Q
Y
P
P
E
F
R
K
K
Site 29
Y245
L
H
A
Q
A
K
P
Y
E
N
I
S
L
C
Q
Site 30
S299
K
T
Q
G
I
W
L
S
P
L
Y
P
R
I
A
Site 31
T309
Y
P
R
I
A
D
G
T
H
K
S
G
E
S
P
Site 32
S312
I
A
D
G
T
H
K
S
G
E
S
P
T
H
F
Site 33
S315
G
T
H
K
S
G
E
S
P
T
H
F
K
A
D
Site 34
S334
L
M
A
Y
N
A
P
S
L
K
E
W
I
D
V
Site 35
Y353
D
L
S
E
T
N
V
Y
L
I
G
S
T
P
G
Site 36
S357
T
N
V
Y
L
I
G
S
T
P
G
R
F
Q
G
Site 37
T358
N
V
Y
L
I
G
S
T
P
G
R
F
Q
G
S
Site 38
S365
T
P
G
R
F
Q
G
S
Q
K
D
N
W
G
H
Site 39
S384
K
L
L
K
D
H
A
S
S
M
P
N
A
E
S
Site 40
S391
S
S
M
P
N
A
E
S
W
P
V
V
G
Q
F
Site 41
S400
P
V
V
G
Q
F
S
S
V
G
S
L
G
A
D
Site 42
S403
G
Q
F
S
S
V
G
S
L
G
A
D
E
S
K
Site 43
S409
G
S
L
G
A
D
E
S
K
W
L
C
S
E
F
Site 44
S414
D
E
S
K
W
L
C
S
E
F
K
E
S
M
L
Site 45
S419
L
C
S
E
F
K
E
S
M
L
T
L
G
K
E
Site 46
T422
E
F
K
E
S
M
L
T
L
G
K
E
S
K
T
Site 47
S427
M
L
T
L
G
K
E
S
K
T
P
G
K
S
S
Site 48
T429
T
L
G
K
E
S
K
T
P
G
K
S
S
V
P
Site 49
S433
E
S
K
T
P
G
K
S
S
V
P
L
Y
L
I
Site 50
S434
S
K
T
P
G
K
S
S
V
P
L
Y
L
I
Y
Site 51
T449
P
S
V
E
N
V
R
T
S
L
E
G
Y
P
A
Site 52
S450
S
V
E
N
V
R
T
S
L
E
G
Y
P
A
G
Site 53
Y454
V
R
T
S
L
E
G
Y
P
A
G
G
S
L
P
Site 54
S459
E
G
Y
P
A
G
G
S
L
P
Y
S
I
Q
T
Site 55
S463
A
G
G
S
L
P
Y
S
I
Q
T
A
E
K
Q
Site 56
S481
H
S
Y
F
H
K
W
S
A
E
T
S
G
R
S
Site 57
S485
H
K
W
S
A
E
T
S
G
R
S
N
A
M
P
Site 58
T496
N
A
M
P
H
I
K
T
Y
M
R
P
S
P
D
Site 59
Y497
A
M
P
H
I
K
T
Y
M
R
P
S
P
D
F
Site 60
S501
I
K
T
Y
M
R
P
S
P
D
F
S
K
I
A
Site 61
T530
G
A
L
E
K
N
G
T
Q
L
M
I
R
S
Y
Site 62
S552
P
S
A
F
G
L
D
S
F
K
V
K
Q
K
F
Site 63
S563
K
Q
K
F
F
A
G
S
Q
E
P
M
A
T
F
Site 64
T569
G
S
Q
E
P
M
A
T
F
P
V
P
Y
D
L
Site 65
Y581
Y
D
L
P
P
E
L
Y
G
S
K
D
R
P
W
Site 66
S583
L
P
P
E
L
Y
G
S
K
D
R
P
W
I
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation