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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POT1
Full Name:
Protection of telomeres protein 1
Alias:
POT1-like telomere end-binding protein
Type:
Mass (Da):
71442
Number AA:
634
UniProt ID:
Q9NUX5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
S
L
V
P
A
T
N
Y
I
Y
T
P
L
N
Q
Site 2
T12
P
A
T
N
Y
I
Y
T
P
L
N
Q
L
K
G
Site 3
Y36
V
K
F
F
K
P
P
Y
L
S
K
G
T
D
Y
Site 4
S38
F
F
K
P
P
Y
L
S
K
G
T
D
Y
C
S
Site 5
S45
S
K
G
T
D
Y
C
S
V
V
T
I
V
D
Q
Site 6
T118
G
A
P
I
I
P
R
T
S
S
K
Y
F
N
F
Site 7
S119
A
P
I
I
P
R
T
S
S
K
Y
F
N
F
T
Site 8
S120
P
I
I
P
R
T
S
S
K
Y
F
N
F
T
T
Site 9
Y122
I
P
R
T
S
S
K
Y
F
N
F
T
T
E
D
Site 10
S141
E
A
L
R
V
W
A
S
T
H
M
S
P
S
W
Site 11
T142
A
L
R
V
W
A
S
T
H
M
S
P
S
W
T
Site 12
S145
V
W
A
S
T
H
M
S
P
S
W
T
L
L
K
Site 13
Y161
C
D
V
Q
P
M
Q
Y
F
D
L
T
C
Q
L
Site 14
T187
L
L
K
V
W
D
G
T
R
T
P
F
P
S
W
Site 15
T189
K
V
W
D
G
T
R
T
P
F
P
S
W
R
V
Site 16
S193
G
T
R
T
P
F
P
S
W
R
V
L
I
Q
D
Site 17
S208
L
V
L
E
G
D
L
S
H
I
H
R
L
Q
N
Site 18
S243
G
S
F
L
R
I
Y
S
L
H
T
K
L
Q
S
Site 19
S250
S
L
H
T
K
L
Q
S
M
N
S
E
N
Q
T
Site 20
S253
T
K
L
Q
S
M
N
S
E
N
Q
T
M
L
S
Site 21
T257
S
M
N
S
E
N
Q
T
M
L
S
L
E
F
H
Site 22
S260
S
E
N
Q
T
M
L
S
L
E
F
H
L
H
G
Site 23
S270
F
H
L
H
G
G
T
S
Y
G
R
G
I
R
V
Site 24
Y271
H
L
H
G
G
T
S
Y
G
R
G
I
R
V
L
Site 25
S281
G
I
R
V
L
P
E
S
N
S
D
V
D
Q
L
Site 26
S283
R
V
L
P
E
S
N
S
D
V
D
Q
L
K
K
Site 27
T298
D
L
E
S
A
N
L
T
A
N
Q
H
S
D
V
Site 28
S309
H
S
D
V
I
C
Q
S
E
P
D
D
S
F
P
Site 29
S314
C
Q
S
E
P
D
D
S
F
P
S
S
G
S
V
Site 30
S317
E
P
D
D
S
F
P
S
S
G
S
V
S
L
Y
Site 31
S318
P
D
D
S
F
P
S
S
G
S
V
S
L
Y
E
Site 32
S320
D
S
F
P
S
S
G
S
V
S
L
Y
E
V
E
Site 33
S322
F
P
S
S
G
S
V
S
L
Y
E
V
E
R
C
Site 34
Y324
S
S
G
S
V
S
L
Y
E
V
E
R
C
Q
Q
Site 35
S333
V
E
R
C
Q
Q
L
S
A
T
I
L
T
D
H
Site 36
Y342
T
I
L
T
D
H
Q
Y
L
E
R
T
P
L
C
Site 37
T346
D
H
Q
Y
L
E
R
T
P
L
C
A
I
L
K
Site 38
S368
R
I
R
A
K
L
R
S
Y
K
P
R
R
L
F
Site 39
Y369
I
R
A
K
L
R
S
Y
K
P
R
R
L
F
Q
Site 40
S377
K
P
R
R
L
F
Q
S
V
K
L
H
C
P
K
Site 41
T406
I
I
F
Q
D
G
A
T
K
T
P
D
V
K
L
Site 42
T408
F
Q
D
G
A
T
K
T
P
D
V
K
L
Q
N
Site 43
S417
D
V
K
L
Q
N
T
S
L
Y
D
S
K
I
W
Site 44
Y419
K
L
Q
N
T
S
L
Y
D
S
K
I
W
T
T
Site 45
T425
L
Y
D
S
K
I
W
T
T
K
N
Q
K
G
R
Site 46
S472
K
L
S
N
K
F
N
S
V
I
P
V
R
S
G
Site 47
Y501
I
Q
G
T
I
H
H
Y
G
C
K
Q
C
S
S
Site 48
S508
Y
G
C
K
Q
C
S
S
L
R
S
I
Q
N
L
Site 49
S511
K
Q
C
S
S
L
R
S
I
Q
N
L
N
S
L
Site 50
S517
R
S
I
Q
N
L
N
S
L
V
D
K
T
S
W
Site 51
T522
L
N
S
L
V
D
K
T
S
W
I
P
S
S
V
Site 52
S523
N
S
L
V
D
K
T
S
W
I
P
S
S
V
A
Site 53
S527
D
K
T
S
W
I
P
S
S
V
A
E
A
L
G
Site 54
Y558
G
T
G
V
L
E
A
Y
L
M
D
S
D
K
F
Site 55
S562
L
E
A
Y
L
M
D
S
D
K
F
F
Q
I
P
Site 56
S571
K
F
F
Q
I
P
A
S
E
V
L
M
D
D
D
Site 57
Y600
P
G
I
K
I
D
A
Y
P
W
L
E
C
F
I
Site 58
Y610
L
E
C
F
I
K
S
Y
N
V
T
N
G
T
D
Site 59
Y622
G
T
D
N
Q
I
C
Y
Q
I
F
D
T
T
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation