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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D23
Full Name:
TBC1 domain family member 23
Alias:
FLJ11046; HCV nonstructural protein 4A-transactivated 1; NS4ATP1; TBC1 domain family, member 23; TBC23
Type:
GTPase activating protein, Rab
Mass (Da):
78322
Number AA:
699
UniProt ID:
Q9NUY8
International Prot ID:
IPI00549789
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
D
V
P
P
L
P
T
S
S
G
D
G
W
E
K
Site 2
S14
V
P
P
L
P
T
S
S
G
D
G
W
E
K
D
Site 3
T35
A
G
G
C
D
L
E
T
L
R
N
I
I
Q
G
Site 4
S94
L
Q
F
I
D
Q
L
S
V
P
E
E
K
A
A
Site 5
T112
L
D
I
E
S
V
I
T
F
Y
C
K
S
R
N
Site 6
Y114
I
E
S
V
I
T
F
Y
C
K
S
R
N
I
K
Site 7
Y122
C
K
S
R
N
I
K
Y
S
T
S
L
S
W
I
Site 8
S123
K
S
R
N
I
K
Y
S
T
S
L
S
W
I
H
Site 9
S125
R
N
I
K
Y
S
T
S
L
S
W
I
H
L
L
Site 10
S127
I
K
Y
S
T
S
L
S
W
I
H
L
L
K
P
Site 11
Y146
Q
L
P
R
S
D
L
Y
N
C
F
Y
A
I
M
Site 12
Y150
S
D
L
Y
N
C
F
Y
A
I
M
N
K
Y
I
Site 13
Y156
F
Y
A
I
M
N
K
Y
I
P
R
D
C
S
Q
Site 14
S162
K
Y
I
P
R
D
C
S
Q
K
G
R
P
F
H
Site 15
Y177
P
F
R
L
L
I
Q
Y
H
E
P
E
L
C
S
Site 16
Y185
H
E
P
E
L
C
S
Y
L
D
T
K
K
I
T
Site 17
T188
E
L
C
S
Y
L
D
T
K
K
I
T
P
D
S
Site 18
T192
Y
L
D
T
K
K
I
T
P
D
S
Y
A
L
N
Site 19
S195
T
K
K
I
T
P
D
S
Y
A
L
N
W
L
G
Site 20
Y196
K
K
I
T
P
D
S
Y
A
L
N
W
L
G
S
Site 21
Y221
T
Q
A
I
W
D
G
Y
L
Q
Q
A
D
P
F
Site 22
T247
N
A
K
E
V
I
L
T
Q
E
S
D
S
K
E
Site 23
S250
E
V
I
L
T
Q
E
S
D
S
K
E
E
V
I
Site 24
S252
I
L
T
Q
E
S
D
S
K
E
E
V
I
K
F
Site 25
T263
V
I
K
F
L
E
N
T
P
S
S
L
N
I
E
Site 26
S265
K
F
L
E
N
T
P
S
S
L
N
I
E
D
I
Site 27
S266
F
L
E
N
T
P
S
S
L
N
I
E
D
I
E
Site 28
S277
E
D
I
E
D
L
F
S
L
A
Q
Y
Y
C
S
Site 29
Y281
D
L
F
S
L
A
Q
Y
Y
C
S
K
T
P
A
Site 30
Y282
L
F
S
L
A
Q
Y
Y
C
S
K
T
P
A
S
Site 31
S284
S
L
A
Q
Y
Y
C
S
K
T
P
A
S
F
R
Site 32
T286
A
Q
Y
Y
C
S
K
T
P
A
S
F
R
K
D
Site 33
Y349
D
C
R
P
A
E
Q
Y
N
A
G
H
L
S
T
Site 34
S355
Q
Y
N
A
G
H
L
S
T
A
F
H
L
D
S
Site 35
S362
S
T
A
F
H
L
D
S
D
L
M
L
Q
N
P
Site 36
S375
N
P
S
E
F
A
Q
S
V
K
S
L
L
E
A
Site 37
S378
E
F
A
Q
S
V
K
S
L
L
E
A
Q
K
Q
Site 38
S386
L
L
E
A
Q
K
Q
S
I
E
S
G
S
I
A
Site 39
S391
K
Q
S
I
E
S
G
S
I
A
G
G
E
H
L
Site 40
S403
E
H
L
C
F
M
G
S
G
R
E
E
E
D
M
Site 41
Y411
G
R
E
E
E
D
M
Y
M
N
M
V
L
A
H
Site 42
Y426
F
L
Q
K
N
K
E
Y
V
S
I
A
S
G
G
Site 43
S459
G
Y
G
H
W
I
A
S
T
S
G
S
R
S
S
Site 44
S461
G
H
W
I
A
S
T
S
G
S
R
S
S
I
N
Site 45
S463
W
I
A
S
T
S
G
S
R
S
S
I
N
S
V
Site 46
S465
A
S
T
S
G
S
R
S
S
I
N
S
V
D
G
Site 47
S466
S
T
S
G
S
R
S
S
I
N
S
V
D
G
E
Site 48
S469
G
S
R
S
S
I
N
S
V
D
G
E
S
P
N
Site 49
S474
I
N
S
V
D
G
E
S
P
N
G
S
S
D
R
Site 50
S478
D
G
E
S
P
N
G
S
S
D
R
G
M
K
S
Site 51
S479
G
E
S
P
N
G
S
S
D
R
G
M
K
S
L
Site 52
S485
S
S
D
R
G
M
K
S
L
V
N
K
M
T
V
Site 53
T491
K
S
L
V
N
K
M
T
V
A
L
K
T
K
S
Site 54
S498
T
V
A
L
K
T
K
S
V
N
V
R
E
K
V
Site 55
S507
N
V
R
E
K
V
I
S
F
I
E
N
T
S
T
Site 56
S513
I
S
F
I
E
N
T
S
T
P
V
D
R
M
S
Site 57
T514
S
F
I
E
N
T
S
T
P
V
D
R
M
S
F
Site 58
S520
S
T
P
V
D
R
M
S
F
N
L
P
W
P
D
Site 59
S529
N
L
P
W
P
D
R
S
C
T
E
R
H
V
S
Site 60
T531
P
W
P
D
R
S
C
T
E
R
H
V
S
S
S
Site 61
S536
S
C
T
E
R
H
V
S
S
S
D
R
V
G
K
Site 62
S537
C
T
E
R
H
V
S
S
S
D
R
V
G
K
P
Site 63
S538
T
E
R
H
V
S
S
S
D
R
V
G
K
P
Y
Site 64
Y545
S
D
R
V
G
K
P
Y
R
G
V
K
P
V
F
Site 65
S553
R
G
V
K
P
V
F
S
I
G
D
E
E
E
Y
Site 66
Y560
S
I
G
D
E
E
E
Y
D
T
D
E
I
D
S
Site 67
T562
G
D
E
E
E
Y
D
T
D
E
I
D
S
S
S
Site 68
S567
Y
D
T
D
E
I
D
S
S
S
M
S
D
D
D
Site 69
S568
D
T
D
E
I
D
S
S
S
M
S
D
D
D
R
Site 70
S569
T
D
E
I
D
S
S
S
M
S
D
D
D
R
K
Site 71
S571
E
I
D
S
S
S
M
S
D
D
D
R
K
E
V
Site 72
Y631
V
S
R
K
G
L
A
Y
I
Q
S
R
Q
A
L
Site 73
S634
K
G
L
A
Y
I
Q
S
R
Q
A
L
N
S
V
Site 74
S640
Q
S
R
Q
A
L
N
S
V
V
K
I
T
S
K
Site 75
S646
N
S
V
V
K
I
T
S
K
K
K
H
P
E
L
Site 76
T655
K
K
H
P
E
L
I
T
F
K
Y
G
N
S
S
Site 77
Y658
P
E
L
I
T
F
K
Y
G
N
S
S
A
S
G
Site 78
S662
T
F
K
Y
G
N
S
S
A
S
G
I
E
I
L
Site 79
Y674
E
I
L
A
I
E
R
Y
L
I
P
N
A
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation