KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
RNF19A
Full Name:
E3 ubiquitin-protein ligase RNF19A
Alias:
Dorfin; Double ring-finger protein; E3 ubiquitin-protein ligase RNF19; EC 6.3.2.-; RING finger protein 19A; RN19A
Type:
Ubiquitin conjugating system; EC 6.3.2.-; Transcription, coactivator/corepressor; Ligase; Ubiquitin ligase
Mass (Da):
90696
Number AA:
838
UniProt ID:
Q9NV58
International Prot ID:
IPI00019056
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0008134
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0000226
GO:0019941
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S33
L
T
S
I
L
D
M
S
L
H
R
Q
M
G
S
Site 2
S40
S
L
H
R
Q
M
G
S
D
R
D
L
Q
S
S
Site 3
S46
G
S
D
R
D
L
Q
S
S
A
S
S
V
S
L
Site 4
S47
S
D
R
D
L
Q
S
S
A
S
S
V
S
L
P
Site 5
S49
R
D
L
Q
S
S
A
S
S
V
S
L
P
S
V
Site 6
S50
D
L
Q
S
S
A
S
S
V
S
L
P
S
V
K
Site 7
S52
Q
S
S
A
S
S
V
S
L
P
S
V
K
K
A
Site 8
S55
A
S
S
V
S
L
P
S
V
K
K
A
P
K
K
Site 9
S66
A
P
K
K
R
R
I
S
I
G
S
L
F
R
R
Site 10
S69
K
R
R
I
S
I
G
S
L
F
R
R
K
K
D
Site 11
S81
K
K
D
N
K
R
K
S
R
E
L
N
G
G
V
Site 12
S93
G
G
V
D
G
I
A
S
I
E
S
I
H
S
E
Site 13
S96
D
G
I
A
S
I
E
S
I
H
S
E
M
C
T
Site 14
S99
A
S
I
E
S
I
H
S
E
M
C
T
D
K
N
Site 15
T103
S
I
H
S
E
M
C
T
D
K
N
S
I
F
S
Site 16
S107
E
M
C
T
D
K
N
S
I
F
S
T
N
T
S
Site 17
S110
T
D
K
N
S
I
F
S
T
N
T
S
S
D
N
Site 18
T111
D
K
N
S
I
F
S
T
N
T
S
S
D
N
G
Site 19
S114
S
I
F
S
T
N
T
S
S
D
N
G
L
T
S
Site 20
S115
I
F
S
T
N
T
S
S
D
N
G
L
T
S
I
Site 21
S121
S
S
D
N
G
L
T
S
I
S
K
Q
I
G
D
Site 22
S123
D
N
G
L
T
S
I
S
K
Q
I
G
D
F
I
Site 23
S140
P
L
C
L
L
R
H
S
K
D
R
F
P
D
I
Site 24
Y162
C
V
D
C
L
R
Q
Y
L
R
I
E
I
S
E
Site 25
S168
Q
Y
L
R
I
E
I
S
E
S
R
V
N
I
S
Site 26
S170
L
R
I
E
I
S
E
S
R
V
N
I
S
C
P
Site 27
S175
S
E
S
R
V
N
I
S
C
P
E
C
T
E
R
Site 28
S193
H
D
I
R
L
I
L
S
D
D
V
L
M
E
K
Site 29
Y201
D
D
V
L
M
E
K
Y
E
E
F
M
L
R
R
Site 30
S274
A
R
Q
E
R
A
Q
S
L
R
L
R
T
I
R
Site 31
T279
A
Q
S
L
R
L
R
T
I
R
S
S
S
I
S
Site 32
S282
L
R
L
R
T
I
R
S
S
S
I
S
Y
S
Q
Site 33
S283
R
L
R
T
I
R
S
S
S
I
S
Y
S
Q
E
Site 34
S284
L
R
T
I
R
S
S
S
I
S
Y
S
Q
E
S
Site 35
S286
T
I
R
S
S
S
I
S
Y
S
Q
E
S
G
A
Site 36
Y287
I
R
S
S
S
I
S
Y
S
Q
E
S
G
A
A
Site 37
S288
R
S
S
S
I
S
Y
S
Q
E
S
G
A
A
A
Site 38
Y341
K
E
I
S
D
L
H
Y
L
S
P
S
G
C
T
Site 39
S408
R
Y
E
G
K
D
V
S
K
H
K
R
N
L
A
Site 40
S463
R
S
G
G
C
G
V
S
A
G
N
G
K
G
V
Site 41
T491
G
T
N
T
A
V
D
T
T
S
V
A
E
A
R
Site 42
S493
N
T
A
V
D
T
T
S
V
A
E
A
R
H
N
Site 43
S502
A
E
A
R
H
N
P
S
I
G
E
G
S
V
G
Site 44
S507
N
P
S
I
G
E
G
S
V
G
G
L
T
G
S
Site 45
S514
S
V
G
G
L
T
G
S
L
S
A
S
G
S
H
Site 46
S516
G
G
L
T
G
S
L
S
A
S
G
S
H
M
D
Site 47
S518
L
T
G
S
L
S
A
S
G
S
H
M
D
R
I
Site 48
S520
G
S
L
S
A
S
G
S
H
M
D
R
I
G
A
Site 49
S533
G
A
I
R
D
N
L
S
E
T
A
S
T
M
A
Site 50
S574
D
V
Q
K
E
R
Y
S
L
S
G
E
S
G
T
Site 51
S576
Q
K
E
R
Y
S
L
S
G
E
S
G
T
V
S
Site 52
S579
R
Y
S
L
S
G
E
S
G
T
V
S
L
G
T
Site 53
S583
S
G
E
S
G
T
V
S
L
G
T
V
S
D
N
Site 54
T586
S
G
T
V
S
L
G
T
V
S
D
N
A
S
T
Site 55
S588
T
V
S
L
G
T
V
S
D
N
A
S
T
K
A
Site 56
S592
G
T
V
S
D
N
A
S
T
K
A
M
A
G
S
Site 57
S603
M
A
G
S
I
L
N
S
Y
I
P
L
D
K
E
Site 58
Y604
A
G
S
I
L
N
S
Y
I
P
L
D
K
E
G
Site 59
S622
E
V
Q
V
D
I
E
S
K
P
S
K
F
R
H
Site 60
S625
V
D
I
E
S
K
P
S
K
F
R
H
N
S
G
Site 61
S631
P
S
K
F
R
H
N
S
G
S
S
S
V
D
D
Site 62
S633
K
F
R
H
N
S
G
S
S
S
V
D
D
G
S
Site 63
S635
R
H
N
S
G
S
S
S
V
D
D
G
S
A
T
Site 64
S640
S
S
S
V
D
D
G
S
A
T
R
S
H
A
G
Site 65
T642
S
V
D
D
G
S
A
T
R
S
H
A
G
G
S
Site 66
S644
D
D
G
S
A
T
R
S
H
A
G
G
S
S
S
Site 67
S649
T
R
S
H
A
G
G
S
S
S
G
L
P
E
G
Site 68
S651
S
H
A
G
G
S
S
S
G
L
P
E
G
K
S
Site 69
S658
S
G
L
P
E
G
K
S
S
A
T
K
W
S
K
Site 70
S659
G
L
P
E
G
K
S
S
A
T
K
W
S
K
E
Site 71
T668
T
K
W
S
K
E
A
T
A
G
K
K
S
K
S
Site 72
S673
E
A
T
A
G
K
K
S
K
S
G
K
L
R
K
Site 73
S675
T
A
G
K
K
S
K
S
G
K
L
R
K
K
G
Site 74
S702
A
Q
L
L
E
Q
Q
S
T
N
S
S
E
F
E
Site 75
T703
Q
L
L
E
Q
Q
S
T
N
S
S
E
F
E
A
Site 76
S706
E
Q
Q
S
T
N
S
S
E
F
E
A
P
S
L
Site 77
S712
S
S
E
F
E
A
P
S
L
S
D
S
M
P
S
Site 78
S714
E
F
E
A
P
S
L
S
D
S
M
P
S
V
A
Site 79
S716
E
A
P
S
L
S
D
S
M
P
S
V
A
D
S
Site 80
S719
S
L
S
D
S
M
P
S
V
A
D
S
H
S
S
Site 81
S723
S
M
P
S
V
A
D
S
H
S
S
H
F
S
E
Site 82
S725
P
S
V
A
D
S
H
S
S
H
F
S
E
F
S
Site 83
S726
S
V
A
D
S
H
S
S
H
F
S
E
F
S
C
Site 84
S729
D
S
H
S
S
H
F
S
E
F
S
C
S
D
L
Site 85
S732
S
S
H
F
S
E
F
S
C
S
D
L
E
S
M
Site 86
S734
H
F
S
E
F
S
C
S
D
L
E
S
M
K
T
Site 87
S738
F
S
C
S
D
L
E
S
M
K
T
S
C
S
H
Site 88
T741
S
D
L
E
S
M
K
T
S
C
S
H
G
S
S
Site 89
S742
D
L
E
S
M
K
T
S
C
S
H
G
S
S
D
Site 90
S744
E
S
M
K
T
S
C
S
H
G
S
S
D
Y
H
Site 91
S748
T
S
C
S
H
G
S
S
D
Y
H
T
R
F
A
Site 92
Y750
C
S
H
G
S
S
D
Y
H
T
R
F
A
T
V
Site 93
T752
H
G
S
S
D
Y
H
T
R
F
A
T
V
N
I
Site 94
T756
D
Y
H
T
R
F
A
T
V
N
I
L
P
E
V
Site 95
S771
E
N
D
R
L
E
N
S
P
H
Q
C
S
I
S
Site 96
S776
E
N
S
P
H
Q
C
S
I
S
V
V
T
Q
T
Site 97
S778
S
P
H
Q
C
S
I
S
V
V
T
Q
T
A
S
Site 98
S787
V
T
Q
T
A
S
C
S
E
V
S
Q
L
N
H
Site 99
Y811
I
K
P
N
V
D
L
Y
F
G
D
A
L
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation