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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MED17
Full Name:
Mediator of RNA polymerase II transcription subunit 17
Alias:
Activator-recruited cofactor 77 kDa component; ARC77; Cofactor required for Sp1 transcriptional activation subunit 6; CRSP complex subunit 6; CRSP6; CRSP77; DRIP80; Mediator complex subunit 17; Thyroid hormone receptor-associated protein complex 80 kDa component; Transcriptional coactivator CRSP77; Trap80; Vitamin D3 receptor-interacting protein complex 80 kDa component
Type:
Nuclear receptor co-regulator, Transcription, coactivator/corepressor
Mass (Da):
72876
Number AA:
651
UniProt ID:
Q9NVC6
International Prot ID:
IPI00301139
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016592
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0016455
GO:0030374
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0030521
GO:0045944
GO:0006367
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
V
R
A
V
R
I
S
I
E
S
A
C
E
K
Site 2
S13
A
V
R
I
S
I
E
S
A
C
E
K
Q
V
H
Site 3
T27
H
E
V
G
L
D
G
T
E
T
Y
L
P
P
L
Site 4
Y30
G
L
D
G
T
E
T
Y
L
P
P
L
S
M
S
Site 5
S35
E
T
Y
L
P
P
L
S
M
S
Q
N
L
A
R
Site 6
S37
Y
L
P
P
L
S
M
S
Q
N
L
A
R
L
A
Site 7
S50
L
A
Q
R
I
D
F
S
Q
G
S
G
S
E
E
Site 8
S53
R
I
D
F
S
Q
G
S
G
S
E
E
E
E
A
Site 9
S55
D
F
S
Q
G
S
G
S
E
E
E
E
A
A
G
Site 10
T63
E
E
E
E
A
A
G
T
E
G
D
A
Q
D
W
Site 11
S75
Q
D
W
P
G
A
G
S
S
A
D
Q
D
D
E
Site 12
S76
D
W
P
G
A
G
S
S
A
D
Q
D
D
E
E
Site 13
S97
P
S
L
W
P
W
D
S
V
R
N
N
L
R
S
Site 14
S104
S
V
R
N
N
L
R
S
A
L
T
E
M
C
V
Site 15
T107
N
N
L
R
S
A
L
T
E
M
C
V
L
Y
D
Site 16
T126
V
R
D
K
K
F
M
T
L
D
P
V
S
Q
D
Site 17
S131
F
M
T
L
D
P
V
S
Q
D
A
L
P
P
K
Site 18
T143
P
P
K
Q
N
P
Q
T
L
Q
L
I
S
K
K
Site 19
S148
P
Q
T
L
Q
L
I
S
K
K
K
S
L
A
G
Site 20
S152
Q
L
I
S
K
K
K
S
L
A
G
A
A
Q
I
Site 21
T168
L
K
G
A
E
R
L
T
K
S
V
T
E
N
Q
Site 22
S170
G
A
E
R
L
T
K
S
V
T
E
N
Q
E
N
Site 23
S185
K
L
Q
R
D
F
N
S
E
L
L
R
L
R
Q
Site 24
S208
D
K
I
L
G
D
L
S
Y
R
S
A
G
S
L
Site 25
S214
L
S
Y
R
S
A
G
S
L
F
P
H
H
G
T
Site 26
T221
S
L
F
P
H
H
G
T
F
E
V
I
K
N
T
Site 27
Y240
D
K
K
I
P
E
D
Y
C
P
L
D
V
Q
I
Site 28
S249
P
L
D
V
Q
I
P
S
D
L
E
G
S
A
Y
Site 29
Y256
S
D
L
E
G
S
A
Y
I
K
V
S
I
Q
K
Site 30
T273
P
D
I
G
D
L
G
T
V
N
L
F
K
R
P
Site 31
S284
F
K
R
P
L
P
K
S
K
P
G
S
P
H
W
Site 32
S288
L
P
K
S
K
P
G
S
P
H
W
Q
T
K
L
Site 33
S333
V
V
K
N
Q
I
I
S
Q
P
F
P
S
L
Q
Site 34
S344
P
S
L
Q
L
S
I
S
L
C
H
S
S
N
D
Site 35
S348
L
S
I
S
L
C
H
S
S
N
D
K
K
S
Q
Site 36
S349
S
I
S
L
C
H
S
S
N
D
K
K
S
Q
K
Site 37
S354
H
S
S
N
D
K
K
S
Q
K
F
A
T
E
K
Site 38
Y369
Q
C
P
E
D
H
L
Y
V
L
E
H
N
L
H
Site 39
T386
I
R
E
F
H
K
Q
T
L
S
S
I
M
M
P
Site 40
S388
E
F
H
K
Q
T
L
S
S
I
M
M
P
H
P
Site 41
S397
I
M
M
P
H
P
A
S
A
P
F
G
H
K
R
Site 42
S408
G
H
K
R
M
R
L
S
G
P
Q
A
F
D
K
Site 43
S420
F
D
K
N
E
I
N
S
L
Q
S
S
E
G
L
Site 44
S424
E
I
N
S
L
Q
S
S
E
G
L
L
E
K
I
Site 45
S450
R
A
A
A
T
I
D
S
L
A
S
R
I
E
D
Site 46
Y471
W
S
N
I
N
D
V
Y
E
S
S
V
K
V
L
Site 47
T513
H
R
D
G
R
V
I
T
L
S
Y
Q
E
Q
E
Site 48
S515
D
G
R
V
I
T
L
S
Y
Q
E
Q
E
L
Q
Site 49
Y516
G
R
V
I
T
L
S
Y
Q
E
Q
E
L
Q
D
Site 50
S527
E
L
Q
D
F
L
L
S
Q
M
S
Q
H
Q
V
Site 51
S530
D
F
L
L
S
Q
M
S
Q
H
Q
V
H
A
V
Site 52
Y578
V
A
S
P
S
G
D
Y
A
I
S
V
R
N
G
Site 53
S581
P
S
G
D
Y
A
I
S
V
R
N
G
P
E
S
Site 54
S588
S
V
R
N
G
P
E
S
G
S
K
I
M
V
Q
Site 55
S607
Q
C
K
D
L
P
K
S
D
V
L
Q
D
N
K
Site 56
Y637
M
E
G
R
N
F
V
Y
K
M
E
L
L
M
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation