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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FANCI
Full Name:
Fanconi anemia group I protein
Alias:
Fanconi anemia, complementation group I; FLJ10719; KIAA1794
Type:
DNA repair; Cell cycle regulation
Mass (Da):
149340
Number AA:
UniProt ID:
Q9NVI1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005694
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0007049
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
L
S
L
A
A
E
K
T
A
D
K
L
Q
E
F
Site 2
T23
K
L
Q
E
F
L
Q
T
L
R
E
G
D
L
T
Site 3
T30
T
L
R
E
G
D
L
T
N
L
L
Q
N
Q
A
Site 4
S54
L
R
A
I
F
K
G
S
P
C
S
E
E
A
G
Site 5
S57
I
F
K
G
S
P
C
S
E
E
A
G
T
L
R
Site 6
T62
P
C
S
E
E
A
G
T
L
R
R
R
K
I
Y
Site 7
T70
L
R
R
R
K
I
Y
T
C
C
I
Q
L
V
E
Site 8
Y146
T
K
K
E
N
L
A
Y
G
K
G
V
L
S
G
Site 9
S152
A
Y
G
K
G
V
L
S
G
E
E
C
K
K
Q
Site 10
Y173
S
G
R
W
D
Q
Q
Y
V
I
Q
L
T
S
M
Site 11
Y215
Q
E
I
P
P
L
V
Y
Q
L
L
V
L
S
S
Site 12
S221
V
Y
Q
L
L
V
L
S
S
K
G
S
R
K
S
Site 13
S222
Y
Q
L
L
V
L
S
S
K
G
S
R
K
S
V
Site 14
S225
L
V
L
S
S
K
G
S
R
K
S
V
L
E
G
Site 15
S228
S
S
K
G
S
R
K
S
V
L
E
G
I
I
A
Site 16
S238
E
G
I
I
A
F
F
S
A
L
D
K
Q
H
N
Site 17
S301
K
V
G
Q
Q
G
D
S
N
N
N
L
S
P
F
Site 18
S306
G
D
S
N
N
N
L
S
P
F
S
I
A
L
L
Site 19
T403
K
K
V
L
D
G
K
T
I
E
T
S
P
S
L
Site 20
T406
L
D
G
K
T
I
E
T
S
P
S
L
S
R
M
Site 21
S407
D
G
K
T
I
E
T
S
P
S
L
S
R
M
P
Site 22
S409
K
T
I
E
T
S
P
S
L
S
R
M
P
N
Q
Site 23
S411
I
E
T
S
P
S
L
S
R
M
P
N
Q
H
A
Site 24
T450
Q
V
L
N
R
V
V
T
R
A
S
S
P
I
S
Site 25
S453
N
R
V
V
T
R
A
S
S
P
I
S
H
F
L
Site 26
S454
R
V
V
T
R
A
S
S
P
I
S
H
F
L
D
Site 27
T482
Q
S
C
S
S
K
V
T
E
A
F
D
Y
L
S
Site 28
S552
K
N
F
K
V
L
G
S
L
S
S
S
Q
C
S
Site 29
S554
F
K
V
L
G
S
L
S
S
S
Q
C
S
Q
S
Site 30
S555
K
V
L
G
S
L
S
S
S
Q
C
S
Q
S
L
Site 31
S556
V
L
G
S
L
S
S
S
Q
C
S
Q
S
L
S
Site 32
S559
S
L
S
S
S
Q
C
S
Q
S
L
S
V
S
Q
Site 33
S561
S
S
S
Q
C
S
Q
S
L
S
V
S
Q
V
H
Site 34
S563
S
Q
C
S
Q
S
L
S
V
S
Q
V
H
V
D
Site 35
S565
C
S
Q
S
L
S
V
S
Q
V
H
V
D
V
H
Site 36
Y575
H
V
D
V
H
S
H
Y
N
S
V
A
N
E
T
Site 37
S596
D
S
L
R
R
C
L
S
Q
Q
A
D
V
R
L
Site 38
Y606
A
D
V
R
L
M
L
Y
E
G
F
Y
D
V
L
Site 39
Y610
L
M
L
Y
E
G
F
Y
D
V
L
R
R
N
S
Site 40
S617
Y
D
V
L
R
R
N
S
Q
L
A
N
S
V
M
Site 41
S622
R
N
S
Q
L
A
N
S
V
M
Q
T
L
L
S
Site 42
S629
S
V
M
Q
T
L
L
S
Q
L
K
Q
F
Y
E
Site 43
T653
K
L
E
A
C
I
L
T
Q
G
D
K
I
S
L
Site 44
S659
L
T
Q
G
D
K
I
S
L
Q
E
P
L
D
Y
Site 45
Y699
E
E
E
E
E
A
F
Y
E
D
L
D
D
I
L
Site 46
S708
D
L
D
D
I
L
E
S
I
T
N
R
M
I
K
Site 47
S726
E
D
F
E
L
D
K
S
A
D
F
S
Q
S
T
Site 48
S730
L
D
K
S
A
D
F
S
Q
S
T
S
I
G
I
Site 49
S732
K
S
A
D
F
S
Q
S
T
S
I
G
I
K
N
Site 50
S734
A
D
F
S
Q
S
T
S
I
G
I
K
N
N
I
Site 51
S759
V
L
I
E
Y
N
F
S
I
S
S
F
S
K
N
Site 52
S762
E
Y
N
F
S
I
S
S
F
S
K
N
R
F
E
Site 53
S764
N
F
S
I
S
S
F
S
K
N
R
F
E
D
I
Site 54
T800
K
T
K
M
A
N
K
T
S
D
S
L
L
S
M
Site 55
S801
T
K
M
A
N
K
T
S
D
S
L
L
S
M
K
Site 56
S803
M
A
N
K
T
S
D
S
L
L
S
M
K
F
V
Site 57
S806
K
T
S
D
S
L
L
S
M
K
F
V
S
S
L
Site 58
T815
K
F
V
S
S
L
L
T
A
L
F
R
D
S
I
Site 59
S821
L
T
A
L
F
R
D
S
I
Q
S
H
Q
E
S
Site 60
S824
L
F
R
D
S
I
Q
S
H
Q
E
S
L
S
V
Site 61
S828
S
I
Q
S
H
Q
E
S
L
S
V
L
R
S
S
Site 62
S830
Q
S
H
Q
E
S
L
S
V
L
R
S
S
N
E
Site 63
S834
E
S
L
S
V
L
R
S
S
N
E
F
M
R
Y
Site 64
S835
S
L
S
V
L
R
S
S
N
E
F
M
R
Y
A
Site 65
Y841
S
S
N
E
F
M
R
Y
A
V
N
V
A
L
Q
Site 66
T856
K
V
Q
Q
L
K
E
T
G
H
V
S
G
P
D
Site 67
S860
L
K
E
T
G
H
V
S
G
P
D
G
Q
N
P
Site 68
T886
R
V
L
L
W
R
Y
T
S
I
P
T
S
V
E
Site 69
S887
V
L
L
W
R
Y
T
S
I
P
T
S
V
E
E
Site 70
S891
R
Y
T
S
I
P
T
S
V
E
E
S
G
K
K
Site 71
S895
I
P
T
S
V
E
E
S
G
K
K
E
K
G
K
Site 72
S903
G
K
K
E
K
G
K
S
I
S
L
L
C
L
E
Site 73
S905
K
E
K
G
K
S
I
S
L
L
C
L
E
G
L
Site 74
S917
E
G
L
Q
K
I
F
S
A
V
Q
Q
F
Y
Q
Site 75
T937
F
L
R
A
L
D
V
T
D
K
E
G
E
E
R
Site 76
S950
E
R
E
D
A
D
V
S
V
T
Q
R
T
A
F
Site 77
T952
E
D
A
D
V
S
V
T
Q
R
T
A
F
Q
I
Site 78
S965
Q
I
R
Q
F
Q
R
S
L
L
N
L
L
S
S
Site 79
S971
R
S
L
L
N
L
L
S
S
Q
E
E
D
F
N
Site 80
S972
S
L
L
N
L
L
S
S
Q
E
E
D
F
N
S
Site 81
S979
S
Q
E
E
D
F
N
S
K
E
A
L
L
L
V
Site 82
S1000
S
K
L
L
E
P
S
S
P
Q
F
V
Q
M
L
Site 83
S1018
S
K
I
C
K
E
N
S
R
E
D
A
L
F
C
Site 84
S1027
E
D
A
L
F
C
K
S
L
M
N
L
L
F
S
Site 85
S1111
T
K
L
K
G
Q
V
S
Q
E
T
L
S
E
E
Site 86
T1114
K
G
Q
V
S
Q
E
T
L
S
E
E
A
S
S
Site 87
S1116
Q
V
S
Q
E
T
L
S
E
E
A
S
S
Q
A
Site 88
S1120
E
T
L
S
E
E
A
S
S
Q
A
T
L
P
N
Site 89
S1121
T
L
S
E
E
A
S
S
Q
A
T
L
P
N
Q
Site 90
T1124
E
E
A
S
S
Q
A
T
L
P
N
Q
P
V
E
Site 91
T1161
P
S
G
S
C
V
D
T
L
L
K
D
L
C
K
Site 92
S1186
Y
Y
L
Q
V
C
Q
S
S
G
G
I
P
K
N
Site 93
Y1215
L
C
Y
S
F
I
S
Y
V
Q
N
K
S
K
S
Site 94
S1220
I
S
Y
V
Q
N
K
S
K
S
L
N
Y
T
G
Site 95
S1222
Y
V
Q
N
K
S
K
S
L
N
Y
T
G
E
K
Site 96
T1226
K
S
K
S
L
N
Y
T
G
E
K
K
E
K
P
Site 97
S1268
E
K
F
L
I
H
L
S
K
K
S
K
V
N
L
Site 98
S1271
L
I
H
L
S
K
K
S
K
V
N
L
M
Q
H
Site 99
S1282
L
M
Q
H
M
K
L
S
T
S
R
D
F
K
I
Site 100
T1283
M
Q
H
M
K
L
S
T
S
R
D
F
K
I
K
Site 101
S1312
E
N
E
E
G
T
A
S
E
H
G
G
Q
N
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation