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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIC8B
Full Name:
Synembryn-B
Alias:
Brain synembrin; Hsyn; Resistance to inhibitors of cholinesterase 8 B; RIC8
Type:
Cytoplasm, Plasma membrane, Cytosol protein
Mass (Da):
60840
Number AA:
536
UniProt ID:
Q9NVN3
International Prot ID:
IPI00018771
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005938
GO:0005829
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0001965
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0008277
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
D
E
E
R
A
L
Y
I
V
R
A
G
E
A
Site 2
Y25
I
E
R
V
L
R
D
Y
S
D
K
H
R
A
T
Site 3
S26
E
R
V
L
R
D
Y
S
D
K
H
R
A
T
F
Site 4
T32
Y
S
D
K
H
R
A
T
F
K
F
E
S
T
D
Site 5
S37
R
A
T
F
K
F
E
S
T
D
E
D
K
R
K
Site 6
T38
A
T
F
K
F
E
S
T
D
E
D
K
R
K
K
Site 7
S104
K
L
N
E
L
D
D
S
L
E
K
V
S
E
F
Site 8
S180
L
L
H
T
D
I
R
S
Q
L
R
Y
E
L
Q
Site 9
Y184
D
I
R
S
Q
L
R
Y
E
L
Q
G
L
P
L
Site 10
S201
Q
I
L
E
S
A
F
S
I
K
W
T
D
E
Y
Site 11
T205
S
A
F
S
I
K
W
T
D
E
Y
E
S
A
I
Site 12
Y208
S
I
K
W
T
D
E
Y
E
S
A
I
D
H
N
Site 13
S220
D
H
N
G
P
P
L
S
P
Q
E
T
D
C
A
Site 14
T224
P
P
L
S
P
Q
E
T
D
C
A
I
E
A
L
Site 15
S241
L
F
N
V
T
V
D
S
W
K
V
H
K
E
S
Site 16
T274
V
G
P
T
E
D
K
T
E
E
L
H
S
N
A
Site 17
S279
D
K
T
E
E
L
H
S
N
A
V
N
L
L
S
Site 18
T301
D
V
L
I
C
P
L
T
H
E
E
T
A
Q
E
Site 19
S357
E
K
R
I
D
K
G
S
S
Y
R
E
G
L
T
Site 20
S358
K
R
I
D
K
G
S
S
Y
R
E
G
L
T
P
Site 21
Y359
R
I
D
K
G
S
S
Y
R
E
G
L
T
P
V
Site 22
T371
T
P
V
L
S
L
L
T
E
C
S
R
A
H
R
Site 23
S374
L
S
L
L
T
E
C
S
R
A
H
R
N
I
R
Site 24
T396
L
P
P
L
R
D
V
T
N
R
P
E
V
G
S
Site 25
S403
T
N
R
P
E
V
G
S
T
V
R
N
K
L
V
Site 26
T404
N
R
P
E
V
G
S
T
V
R
N
K
L
V
R
Site 27
S438
L
C
K
E
R
V
D
S
L
L
K
Y
T
G
Y
Site 28
Y442
R
V
D
S
L
L
K
Y
T
G
Y
G
N
A
A
Site 29
Y467
G
G
R
G
D
N
W
Y
S
E
D
E
D
T
D
Site 30
S468
G
R
G
D
N
W
Y
S
E
D
E
D
T
D
T
Site 31
T473
W
Y
S
E
D
E
D
T
D
T
E
E
Y
K
N
Site 32
T475
S
E
D
E
D
T
D
T
E
E
Y
K
N
A
K
Site 33
Y478
E
D
T
D
T
E
E
Y
K
N
A
K
P
N
I
Site 34
T504
P
N
P
I
D
E
M
T
E
E
Q
K
E
Y
E
Site 35
Y510
M
T
E
E
Q
K
E
Y
E
A
M
K
L
V
N
Site 36
S523
V
N
M
L
D
K
L
S
R
R
A
D
V
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation