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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX18
Full Name:
ATP-dependent RNA helicase DDX18
Alias:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18; DEAD box protein 18; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated); DEAD-box protein 18; FLJ33908; MrDb; Myc-regulated DEAD box protein; Myc-regulated DEAD-box protein; Putative ATP-dependent RNA helicase
Type:
Helicase; EC 3.6.1.-
Mass (Da):
75407
Number AA:
670
UniProt ID:
Q9NVP1
International Prot ID:
IPI00301323
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
H
L
P
M
K
L
L
Site 2
S36
G
A
S
N
L
T
L
S
E
T
Q
N
G
D
V
Site 3
T38
S
N
L
T
L
S
E
T
Q
N
G
D
V
S
E
Site 4
S44
E
T
Q
N
G
D
V
S
E
E
T
M
G
S
R
Site 5
S50
V
S
E
E
T
M
G
S
R
K
V
K
K
S
K
Site 6
S56
G
S
R
K
V
K
K
S
K
Q
K
P
M
N
V
Site 7
S66
K
P
M
N
V
G
L
S
E
T
Q
N
G
G
M
Site 8
T68
M
N
V
G
L
S
E
T
Q
N
G
G
M
S
Q
Site 9
S74
E
T
Q
N
G
G
M
S
Q
E
A
V
G
N
I
Site 10
S86
G
N
I
K
V
T
K
S
P
Q
K
S
T
V
L
Site 11
S90
V
T
K
S
P
Q
K
S
T
V
L
T
N
G
E
Site 12
T94
P
Q
K
S
T
V
L
T
N
G
E
A
A
M
Q
Site 13
S103
G
E
A
A
M
Q
S
S
N
S
E
S
K
K
K
Site 14
S105
A
A
M
Q
S
S
N
S
E
S
K
K
K
K
K
Site 15
S107
M
Q
S
S
N
S
E
S
K
K
K
K
K
K
K
Site 16
T125
V
N
D
A
E
P
D
T
K
K
A
K
T
E
N
Site 17
T130
P
D
T
K
K
A
K
T
E
N
K
G
K
S
E
Site 18
S136
K
T
E
N
K
G
K
S
E
E
E
S
A
E
T
Site 19
S140
K
G
K
S
E
E
E
S
A
E
T
T
K
E
T
Site 20
T143
S
E
E
E
S
A
E
T
T
K
E
T
E
N
N
Site 21
S161
P
D
N
D
E
D
E
S
E
V
P
S
L
P
L
Site 22
S165
E
D
E
S
E
V
P
S
L
P
L
G
L
T
G
Site 23
T171
P
S
L
P
L
G
L
T
G
A
F
E
D
T
S
Site 24
S181
F
E
D
T
S
F
A
S
L
C
N
L
V
N
E
Site 25
S209
M
T
E
I
Q
H
K
S
I
R
P
L
L
E
G
Site 26
T225
D
L
L
A
A
A
K
T
G
S
G
K
T
L
A
Site 27
S227
L
A
A
A
K
T
G
S
G
K
T
L
A
F
L
Site 28
T276
G
V
L
K
E
L
M
T
H
H
V
H
T
Y
G
Site 29
S289
Y
G
L
I
M
G
G
S
N
R
S
A
E
A
Q
Site 30
T319
L
L
D
H
M
Q
N
T
P
G
F
M
Y
K
N
Site 31
T360
L
L
P
T
R
R
Q
T
M
L
F
S
A
T
Q
Site 32
T368
M
L
F
S
A
T
Q
T
R
K
V
E
D
L
A
Site 33
S378
V
E
D
L
A
R
I
S
L
K
K
E
P
L
Y
Site 34
Y385
S
L
K
K
E
P
L
Y
V
G
V
D
D
D
K
Site 35
T396
D
D
D
K
A
N
A
T
V
D
G
L
E
Q
G
Site 36
Y404
V
D
G
L
E
Q
G
Y
V
V
C
P
S
E
K
Site 37
T418
K
R
F
L
L
L
F
T
F
L
K
K
N
R
K
Site 38
Y440
S
S
C
M
S
V
K
Y
H
Y
E
L
L
N
Y
Site 39
Y442
C
M
S
V
K
Y
H
Y
E
L
L
N
Y
I
D
Site 40
Y447
Y
H
Y
E
L
L
N
Y
I
D
L
P
V
L
A
Site 41
Y500
E
V
D
W
I
V
Q
Y
D
P
P
D
D
P
K
Site 42
Y509
P
P
D
D
P
K
E
Y
I
H
R
V
G
R
T
Site 43
Y540
E
E
L
G
F
L
R
Y
L
K
Q
S
K
V
P
Site 44
S544
F
L
R
Y
L
K
Q
S
K
V
P
L
S
E
F
Site 45
S549
K
Q
S
K
V
P
L
S
E
F
D
F
S
W
S
Site 46
S554
P
L
S
E
F
D
F
S
W
S
K
I
S
D
I
Site 47
S559
D
F
S
W
S
K
I
S
D
I
Q
S
Q
L
E
Site 48
S563
S
K
I
S
D
I
Q
S
Q
L
E
K
L
I
E
Site 49
Y573
E
K
L
I
E
K
N
Y
F
L
H
K
S
A
Q
Site 50
S578
K
N
Y
F
L
H
K
S
A
Q
E
A
Y
K
S
Site 51
S585
S
A
Q
E
A
Y
K
S
Y
I
R
A
Y
D
S
Site 52
Y586
A
Q
E
A
Y
K
S
Y
I
R
A
Y
D
S
H
Site 53
Y590
Y
K
S
Y
I
R
A
Y
D
S
H
S
L
K
Q
Site 54
S592
S
Y
I
R
A
Y
D
S
H
S
L
K
Q
I
F
Site 55
S594
I
R
A
Y
D
S
H
S
L
K
Q
I
F
N
V
Site 56
Y643
G
G
G
G
G
F
G
Y
Q
K
T
K
K
V
E
Site 57
T646
G
G
F
G
Y
Q
K
T
K
K
V
E
K
S
K
Site 58
S652
K
T
K
K
V
E
K
S
K
I
F
K
H
I
S
Site 59
S659
S
K
I
F
K
H
I
S
K
K
S
S
D
S
R
Site 60
S662
F
K
H
I
S
K
K
S
S
D
S
R
Q
F
S
Site 61
S663
K
H
I
S
K
K
S
S
D
S
R
Q
F
S
H
Site 62
S665
I
S
K
K
S
S
D
S
R
Q
F
S
H
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation