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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL11
Full Name:
Kelch-like protein 11
Alias:
FLJ10572; kelch-like 11; KLH11
Type:
Unknown function
Mass (Da):
80148
Number AA:
708
UniProt ID:
Q9NVR0
International Prot ID:
IPI00018726
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
L
E
M
E
S
M
E
T
A
A
A
G
S
A
G
Site 2
T45
A
E
V
R
G
S
G
T
V
D
F
G
P
G
P
Site 3
S74
E
A
E
D
F
E
C
S
S
H
C
S
E
L
S
Site 4
S75
A
E
D
F
E
C
S
S
H
C
S
E
L
S
W
Site 5
S81
S
S
H
C
S
E
L
S
W
R
Q
N
E
Q
R
Site 6
S113
R
E
F
R
A
H
R
S
V
L
A
A
A
T
E
Site 7
Y121
V
L
A
A
A
T
E
Y
F
T
P
L
L
S
G
Site 8
S127
E
Y
F
T
P
L
L
S
G
Q
F
S
E
S
R
Site 9
S131
P
L
L
S
G
Q
F
S
E
S
R
S
G
R
V
Site 10
S133
L
S
G
Q
F
S
E
S
R
S
G
R
V
E
M
Site 11
S135
G
Q
F
S
E
S
R
S
G
R
V
E
M
R
K
Site 12
S144
R
V
E
M
R
K
W
S
S
E
P
G
P
E
P
Site 13
S145
V
E
M
R
K
W
S
S
E
P
G
P
E
P
D
Site 14
T153
E
P
G
P
E
P
D
T
V
E
A
V
I
E
Y
Site 15
S169
Y
T
G
R
I
R
V
S
T
G
S
V
H
E
V
Site 16
T170
T
G
R
I
R
V
S
T
G
S
V
H
E
V
L
Site 17
S203
L
K
K
K
L
H
L
S
N
C
V
A
I
H
S
Site 18
T243
I
Q
D
E
E
F
Y
T
L
P
F
H
L
I
R
Site 19
S254
H
L
I
R
D
W
L
S
D
L
E
I
T
V
D
Site 20
T269
S
E
E
V
L
F
E
T
V
L
K
W
V
Q
R
Site 21
Y284
N
A
E
E
R
E
R
Y
F
E
E
L
F
K
L
Site 22
Y301
L
S
Q
M
K
P
T
Y
L
T
R
H
V
K
P
Site 23
T303
Q
M
K
P
T
Y
L
T
R
H
V
K
P
E
R
Site 24
T345
S
G
T
C
Q
H
P
T
S
H
V
S
L
L
P
Site 25
S346
G
T
C
Q
H
P
T
S
H
V
S
L
L
P
R
Site 26
S349
Q
H
P
T
S
H
V
S
L
L
P
R
Y
G
Q
Site 27
Y373
G
V
S
E
G
G
D
Y
L
S
E
C
V
G
Y
Site 28
S375
S
E
G
G
D
Y
L
S
E
C
V
G
Y
F
V
Site 29
Y380
Y
L
S
E
C
V
G
Y
F
V
D
E
D
R
W
Site 30
T422
M
E
P
G
F
A
K
T
V
E
R
Y
N
P
N
Site 31
S445
S
L
M
T
R
K
H
S
F
G
L
T
E
V
K
Site 32
T449
R
K
H
S
F
G
L
T
E
V
K
G
K
L
Y
Site 33
Y456
T
E
V
K
G
K
L
Y
S
I
G
G
H
G
N
Site 34
S457
E
V
K
G
K
L
Y
S
I
G
G
H
G
N
F
Site 35
S465
I
G
G
H
G
N
F
S
P
G
F
K
D
V
T
Site 36
T472
S
P
G
F
K
D
V
T
V
Y
N
P
E
L
D
Site 37
S486
D
K
W
H
N
L
E
S
A
P
K
I
L
R
D
Site 38
T510
F
V
Y
I
A
A
R
T
P
V
D
R
D
T
E
Site 39
T516
R
T
P
V
D
R
D
T
E
D
G
L
K
A
V
Site 40
T525
D
G
L
K
A
V
I
T
C
Y
D
T
E
T
R
Site 41
Y527
L
K
A
V
I
T
C
Y
D
T
E
T
R
Q
W
Site 42
S539
R
Q
W
Q
D
V
E
S
L
P
L
I
D
N
Y
Site 43
Y559
S
V
V
N
S
N
F
Y
Q
T
A
S
C
C
P
Site 44
S582
E
A
V
R
K
I
A
S
Q
V
S
D
E
I
L
Site 45
S585
R
K
I
A
S
Q
V
S
D
E
I
L
E
S
L
Site 46
Y627
S
D
D
I
D
K
Q
Y
R
K
E
A
Y
R
Y
Site 47
Y634
Y
R
K
E
A
Y
R
Y
C
A
E
R
K
R
W
Site 48
T655
P
Q
P
R
C
R
A
T
A
C
H
V
R
I
P
Site 49
Y663
A
C
H
V
R
I
P
Y
R
Y
L
H
G
T
Q
Site 50
Y665
H
V
R
I
P
Y
R
Y
L
H
G
T
Q
R
Y
Site 51
T669
P
Y
R
Y
L
H
G
T
Q
R
Y
P
M
P
Q
Site 52
Y672
Y
L
H
G
T
Q
R
Y
P
M
P
Q
N
L
M
Site 53
S703
L
N
M
R
R
V
P
S
S
Q
I
E
C
_
_
Site 54
S704
N
M
R
R
V
P
S
S
Q
I
E
C
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation