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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLR3E
Full Name:
DNA-directed RNA polymerase III subunit RPC5
Alias:
DNA-directed RNA polymerase III 80 kDa polypeptide; EC 2.7.7.6; KIAA1452; RPC5
Type:
Transferase, Transcription initiation complex
Mass (Da):
79898
Number AA:
708
UniProt ID:
Q9NVU0
International Prot ID:
IPI00018245
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003899
GO:0003899
GO:0016740
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
GO:0006350
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
K
S
L
A
E
K
L
Y
L
F
Q
Y
P
V
R
Site 2
Y30
E
K
L
Y
L
F
Q
Y
P
V
R
P
A
S
M
Site 3
S36
Q
Y
P
V
R
P
A
S
M
T
Y
D
D
I
P
Site 4
T38
P
V
R
P
A
S
M
T
Y
D
D
I
P
H
L
Site 5
S46
Y
D
D
I
P
H
L
S
A
K
I
K
P
K
Q
Site 6
T64
E
L
E
M
A
I
D
T
L
N
P
N
Y
C
R
Site 7
Y69
I
D
T
L
N
P
N
Y
C
R
S
K
G
E
Q
Site 8
T89
D
G
A
C
A
D
E
T
S
T
Y
S
S
K
L
Site 9
S90
G
A
C
A
D
E
T
S
T
Y
S
S
K
L
M
Site 10
T91
A
C
A
D
E
T
S
T
Y
S
S
K
L
M
D
Site 11
Y92
C
A
D
E
T
S
T
Y
S
S
K
L
M
D
K
Site 12
S94
D
E
T
S
T
Y
S
S
K
L
M
D
K
Q
T
Site 13
T101
S
K
L
M
D
K
Q
T
F
C
S
S
Q
T
T
Site 14
S105
D
K
Q
T
F
C
S
S
Q
T
T
S
N
T
S
Site 15
T107
Q
T
F
C
S
S
Q
T
T
S
N
T
S
R
Y
Site 16
T108
T
F
C
S
S
Q
T
T
S
N
T
S
R
Y
A
Site 17
S109
F
C
S
S
Q
T
T
S
N
T
S
R
Y
A
A
Site 18
Y119
S
R
Y
A
A
A
L
Y
R
Q
G
E
L
H
L
Site 19
T127
R
Q
G
E
L
H
L
T
P
L
H
G
I
L
Q
Site 20
S138
G
I
L
Q
L
R
P
S
F
S
Y
L
D
K
A
Site 21
S140
L
Q
L
R
P
S
F
S
Y
L
D
K
A
D
A
Site 22
Y141
Q
L
R
P
S
F
S
Y
L
D
K
A
D
A
K
Site 23
S161
A
A
N
E
A
G
D
S
S
Q
D
E
A
E
D
Site 24
S162
A
N
E
A
G
D
S
S
Q
D
E
A
E
D
D
Site 25
T174
E
D
D
V
K
Q
I
T
V
R
F
S
R
P
E
Site 26
S178
K
Q
I
T
V
R
F
S
R
P
E
S
E
Q
A
Site 27
S182
V
R
F
S
R
P
E
S
E
Q
A
R
Q
R
R
Site 28
S192
A
R
Q
R
R
V
Q
S
Y
E
F
L
Q
K
K
Site 29
Y193
R
Q
R
R
V
Q
S
Y
E
F
L
Q
K
K
H
Site 30
Y210
E
P
W
V
H
L
H
Y
Y
G
L
R
D
S
R
Site 31
Y211
P
W
V
H
L
H
Y
Y
G
L
R
D
S
R
S
Site 32
S216
H
Y
Y
G
L
R
D
S
R
S
E
H
E
R
Q
Site 33
S218
Y
G
L
R
D
S
R
S
E
H
E
R
Q
Y
L
Site 34
Y224
R
S
E
H
E
R
Q
Y
L
L
C
P
G
S
S
Site 35
S230
Q
Y
L
L
C
P
G
S
S
G
V
E
N
T
E
Site 36
T236
G
S
S
G
V
E
N
T
E
L
V
K
S
P
S
Site 37
S241
E
N
T
E
L
V
K
S
P
S
E
Y
L
M
M
Site 38
S253
L
M
M
L
M
P
P
S
Q
E
E
E
K
D
K
Site 39
S265
K
D
K
P
V
A
P
S
N
V
L
S
M
A
Q
Site 40
Y333
V
V
K
S
D
I
L
Y
P
K
D
S
S
S
P
Site 41
S337
D
I
L
Y
P
K
D
S
S
S
P
H
S
G
V
Site 42
S338
I
L
Y
P
K
D
S
S
S
P
H
S
G
V
P
Site 43
S339
L
Y
P
K
D
S
S
S
P
H
S
G
V
P
A
Site 44
S342
K
D
S
S
S
P
H
S
G
V
P
A
E
V
L
Site 45
Y404
G
W
E
F
I
L
P
Y
D
G
E
F
I
K
K
Site 46
Y434
Q
A
K
L
E
K
V
Y
N
L
V
K
E
T
M
Site 47
S449
P
K
K
P
D
A
Q
S
G
P
A
G
L
V
C
Site 48
S503
R
I
K
E
E
P
V
S
E
E
G
E
E
D
E
Site 49
T521
A
E
E
E
P
M
D
T
S
P
S
G
L
H
S
Site 50
S522
E
E
E
P
M
D
T
S
P
S
G
L
H
S
K
Site 51
S524
E
P
M
D
T
S
P
S
G
L
H
S
K
L
A
Site 52
S528
T
S
P
S
G
L
H
S
K
L
A
N
G
L
P
Site 53
T542
P
L
G
R
A
A
G
T
D
S
F
N
G
H
P
Site 54
S544
G
R
A
A
G
T
D
S
F
N
G
H
P
P
Q
Site 55
T556
P
P
Q
G
C
A
S
T
P
V
A
R
E
L
K
Site 56
T577
F
Q
R
Q
F
V
L
T
L
S
E
L
K
R
L
Site 57
S579
R
Q
F
V
L
T
L
S
E
L
K
R
L
F
N
Site 58
T597
A
S
L
P
P
G
H
T
L
F
S
G
I
S
D
Site 59
S600
P
P
G
H
T
L
F
S
G
I
S
D
R
M
L
Site 60
S603
H
T
L
F
S
G
I
S
D
R
M
L
Q
D
T
Site 61
T610
S
D
R
M
L
Q
D
T
V
L
A
A
G
C
K
Site 62
T627
L
V
P
F
P
P
Q
T
A
A
S
P
D
E
Q
Site 63
S630
F
P
P
Q
T
A
A
S
P
D
E
Q
K
V
F
Site 64
S646
L
W
E
S
G
D
M
S
D
Q
H
R
Q
V
L
Site 65
S658
Q
V
L
L
E
I
F
S
K
N
Y
R
V
R
R
Site 66
S670
V
R
R
N
M
I
Q
S
R
L
T
Q
E
C
G
Site 67
T673
N
M
I
Q
S
R
L
T
Q
E
C
G
E
D
L
Site 68
Y701
V
S
Y
G
G
M
W
Y
L
K
G
T
V
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation