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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KBTBD4
Full Name:
Kelch repeat and BTB domain-containing protein 4
Alias:
BTB and kelch domain-containing protein 4
Type:
Mass (Da):
58144
Number AA:
518
UniProt ID:
Q9NVX7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
E
S
P
E
E
P
G
A
S
Site 2
S10
S
P
E
E
P
G
A
S
M
D
E
N
Y
F
V
Site 3
Y15
G
A
S
M
D
E
N
Y
F
V
N
Y
T
F
K
Site 4
S27
T
F
K
D
R
S
H
S
G
R
V
A
Q
G
I
Site 5
T48
E
E
L
F
A
D
V
T
I
S
V
E
G
R
E
Site 6
Y119
A
E
E
L
Q
E
I
Y
E
V
S
D
M
Y
Q
Site 7
S122
L
Q
E
I
Y
E
V
S
D
M
Y
Q
L
T
S
Site 8
Y125
I
Y
E
V
S
D
M
Y
Q
L
T
S
L
F
E
Site 9
S129
S
D
M
Y
Q
L
T
S
L
F
E
E
C
S
R
Site 10
S158
M
W
L
A
D
R
H
S
D
P
E
L
Y
T
A
Site 11
Y163
R
H
S
D
P
E
L
Y
T
A
A
K
H
C
A
Site 12
S202
I
S
D
G
V
P
C
S
Q
N
P
T
E
A
I
Site 13
T206
V
P
C
S
Q
N
P
T
E
A
I
E
A
W
I
Site 14
S226
E
R
E
A
F
A
E
S
L
R
T
S
L
K
E
Site 15
S230
F
A
E
S
L
R
T
S
L
K
E
I
G
E
N
Site 16
Y241
I
G
E
N
V
H
I
Y
L
I
G
K
E
S
S
Site 17
S247
I
Y
L
I
G
K
E
S
S
R
T
H
S
L
A
Site 18
S248
Y
L
I
G
K
E
S
S
R
T
H
S
L
A
V
Site 19
T250
I
G
K
E
S
S
R
T
H
S
L
A
V
S
L
Site 20
S252
K
E
S
S
R
T
H
S
L
A
V
S
L
H
C
Site 21
S256
R
T
H
S
L
A
V
S
L
H
C
A
E
D
D
Site 22
S264
L
H
C
A
E
D
D
S
I
S
V
S
G
Q
N
Site 23
S266
C
A
E
D
D
S
I
S
V
S
G
Q
N
S
L
Site 24
S268
E
D
D
S
I
S
V
S
G
Q
N
S
L
C
H
Site 25
T322
P
R
D
R
L
Q
H
T
L
V
S
V
P
G
K
Site 26
S325
R
L
Q
H
T
L
V
S
V
P
G
K
D
A
I
Site 27
Y333
V
P
G
K
D
A
I
Y
S
L
G
G
K
T
L
Site 28
S334
P
G
K
D
A
I
Y
S
L
G
G
K
T
L
Q
Site 29
T339
I
Y
S
L
G
G
K
T
L
Q
D
T
L
S
N
Site 30
T343
G
G
K
T
L
Q
D
T
L
S
N
A
V
I
Y
Site 31
S345
K
T
L
Q
D
T
L
S
N
A
V
I
Y
Y
R
Site 32
Y350
T
L
S
N
A
V
I
Y
Y
R
V
G
D
N
V
Site 33
Y351
L
S
N
A
V
I
Y
Y
R
V
G
D
N
V
W
Site 34
T394
E
N
D
L
D
F
F
T
K
P
S
R
L
I
Q
Site 35
Y415
D
K
C
H
V
K
P
Y
V
L
P
F
A
G
R
Site 36
Y444
E
G
D
S
L
V
C
Y
N
P
L
L
D
S
F
Site 37
S461
L
C
L
P
E
A
W
S
S
A
P
S
L
W
K
Site 38
S465
E
A
W
S
S
A
P
S
L
W
K
I
A
S
C
Site 39
S475
K
I
A
S
C
N
G
S
I
Y
V
F
R
D
R
Site 40
Y477
A
S
C
N
G
S
I
Y
V
F
R
D
R
Y
K
Site 41
Y483
I
Y
V
F
R
D
R
Y
K
K
G
D
A
N
T
Site 42
T497
T
Y
K
L
D
P
A
T
S
A
V
T
V
T
R
Site 43
S498
Y
K
L
D
P
A
T
S
A
V
T
V
T
R
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation