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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLR3B
Full Name:
DNA-directed RNA polymerase III subunit RPC2
Alias:
DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide; FLJ10388; polymerase (RNA) III (DNA directed) polypeptide B; RNA polymerase III subunit 2; RNA polymerase III subunit RPC2; RPC2
Type:
EC 2.7.7.6; Transferase; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Transcription initiation complex
Mass (Da):
127785
Number AA:
1133
UniProt ID:
Q9NW08
International Prot ID:
IPI00301346
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003899
GO:0032549
PhosphoSite+
KinaseNET
Biological Process:
GO:0045089
GO:0032728
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
A
E
E
F
G
N
L
T
P
E
Q
L
A
A
P
Site 2
Y49
Q
H
I
D
S
F
N
Y
F
I
N
V
E
I
K
Site 3
S67
K
A
N
E
K
V
T
S
D
A
D
P
M
W
Y
Site 4
Y74
S
D
A
D
P
M
W
Y
L
K
Y
L
N
I
Y
Site 5
S90
G
L
P
D
V
E
E
S
F
N
V
T
R
P
V
Site 6
T94
V
E
E
S
F
N
V
T
R
P
V
S
P
H
E
Site 7
S98
F
N
V
T
R
P
V
S
P
H
E
C
R
L
R
Site 8
T108
E
C
R
L
R
D
M
T
Y
S
A
P
I
T
V
Site 9
Y109
C
R
L
R
D
M
T
Y
S
A
P
I
T
V
D
Site 10
S110
R
L
R
D
M
T
Y
S
A
P
I
T
V
D
I
Site 11
T114
M
T
Y
S
A
P
I
T
V
D
I
E
Y
T
R
Site 12
Y119
P
I
T
V
D
I
E
Y
T
R
G
S
Q
R
I
Site 13
S123
D
I
E
Y
T
R
G
S
Q
R
I
I
R
N
A
Site 14
S202
R
K
G
A
V
G
A
S
V
T
S
S
T
H
E
Site 15
S206
V
G
A
S
V
T
S
S
T
H
E
K
K
S
R
Site 16
T207
G
A
S
V
T
S
S
T
H
E
K
K
S
R
T
Site 17
S212
S
S
T
H
E
K
K
S
R
T
N
M
A
V
K
Site 18
Y224
A
V
K
Q
G
R
F
Y
L
R
H
N
T
L
S
Site 19
T229
R
F
Y
L
R
H
N
T
L
S
E
D
I
P
I
Site 20
Y286
T
Q
M
Q
A
L
K
Y
I
G
N
K
V
R
R
Site 21
Y356
N
K
V
D
D
R
D
Y
Y
G
N
K
R
L
E
Site 22
Y357
K
V
D
D
R
D
Y
Y
G
N
K
R
L
E
L
Site 23
T421
G
M
V
N
A
I
S
T
G
N
W
S
L
K
R
Site 24
S425
A
I
S
T
G
N
W
S
L
K
R
F
K
M
D
Site 25
T437
K
M
D
R
Q
G
V
T
Q
V
L
S
R
L
S
Site 26
S456
L
G
M
M
T
R
I
S
S
Q
F
E
K
T
R
Site 27
S457
G
M
M
T
R
I
S
S
Q
F
E
K
T
R
K
Site 28
T462
I
S
S
Q
F
E
K
T
R
K
V
S
G
P
R
Site 29
S466
F
E
K
T
R
K
V
S
G
P
R
S
L
Q
P
Site 30
S470
R
K
V
S
G
P
R
S
L
Q
P
S
Q
W
G
Site 31
S474
G
P
R
S
L
Q
P
S
Q
W
G
M
L
C
P
Site 32
S482
Q
W
G
M
L
C
P
S
D
T
P
E
G
E
A
Site 33
T484
G
M
L
C
P
S
D
T
P
E
G
E
A
C
G
Site 34
T558
D
H
K
K
L
V
N
T
F
R
L
M
R
R
A
Site 35
Y567
R
L
M
R
R
A
G
Y
I
N
E
F
V
S
I
Site 36
S573
G
Y
I
N
E
F
V
S
I
S
T
N
L
T
D
Site 37
Y584
N
L
T
D
R
C
V
Y
I
S
S
D
G
G
R
Site 38
S586
T
D
R
C
V
Y
I
S
S
D
G
G
R
L
C
Site 39
S587
D
R
C
V
Y
I
S
S
D
G
G
R
L
C
R
Site 40
Y596
G
G
R
L
C
R
P
Y
I
I
V
K
K
Q
K
Site 41
Y632
L
H
E
S
L
V
E
Y
L
D
V
N
E
E
N
Site 42
Y646
N
D
C
N
I
A
L
Y
E
H
T
I
N
K
D
Site 43
Y674
V
C
A
G
L
I
P
Y
P
H
H
N
Q
S
P
Site 44
Y685
N
Q
S
P
R
N
T
Y
Q
C
A
M
G
K
Q
Site 45
T707
N
Q
R
N
R
I
D
T
L
M
Y
L
L
A
Y
Site 46
Y710
N
R
I
D
T
L
M
Y
L
L
A
Y
P
Q
K
Site 47
Y714
T
L
M
Y
L
L
A
Y
P
Q
K
P
M
V
K
Site 48
S761
A
L
V
L
N
K
A
S
L
D
R
G
F
G
R
Site 49
T783
K
C
T
L
K
R
Y
T
N
Q
T
F
D
K
V
Site 50
T786
L
K
R
Y
T
N
Q
T
F
D
K
V
M
G
P
Site 51
T799
G
P
M
L
D
A
A
T
R
K
P
I
W
R
H
Site 52
S816
L
D
A
D
G
I
C
S
P
G
E
K
V
E
N
Site 53
S831
K
Q
V
L
V
N
K
S
M
P
T
V
T
Q
I
Site 54
T836
N
K
S
M
P
T
V
T
Q
I
P
L
E
G
S
Site 55
Y851
N
V
P
Q
Q
P
Q
Y
K
D
V
P
I
T
Y
Site 56
S864
T
Y
K
G
A
T
D
S
Y
I
E
K
V
M
I
Site 57
Y865
Y
K
G
A
T
D
S
Y
I
E
K
V
M
I
S
Site 58
S872
Y
I
E
K
V
M
I
S
S
N
A
E
D
A
F
Site 59
S873
I
E
K
V
M
I
S
S
N
A
E
D
A
F
L
Site 60
T888
I
K
M
L
L
R
Q
T
R
R
P
E
I
G
D
Site 61
S898
P
E
I
G
D
K
F
S
S
R
H
G
Q
K
G
Site 62
S899
E
I
G
D
K
F
S
S
R
H
G
Q
K
G
V
Site 63
Y960
V
L
D
G
R
F
H
Y
G
T
A
F
G
G
S
Site 64
T962
D
G
R
F
H
Y
G
T
A
F
G
G
S
K
V
Site 65
Y981
E
D
L
V
R
H
G
Y
N
Y
L
G
K
D
Y
Site 66
Y983
L
V
R
H
G
Y
N
Y
L
G
K
D
Y
V
T
Site 67
Y988
Y
N
Y
L
G
K
D
Y
V
T
S
G
I
T
G
Site 68
S991
L
G
K
D
Y
V
T
S
G
I
T
G
E
P
L
Site 69
Y1003
E
P
L
E
A
Y
I
Y
F
G
P
V
Y
Y
Q
Site 70
Y1008
Y
I
Y
F
G
P
V
Y
Y
Q
K
L
K
H
M
Site 71
T1032
R
G
P
R
A
V
L
T
R
Q
P
T
E
G
R
Site 72
T1036
A
V
L
T
R
Q
P
T
E
G
R
S
R
D
G
Site 73
S1097
G
W
C
H
Y
C
K
S
S
C
H
V
S
S
L
Site 74
S1098
W
C
H
Y
C
K
S
S
C
H
V
S
S
L
R
Site 75
S1102
C
K
S
S
C
H
V
S
S
L
R
I
P
Y
A
Site 76
S1103
K
S
S
C
H
V
S
S
L
R
I
P
Y
A
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation