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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBCE7IP1
Full Name:
E3 ubiquitin-protein ligase RNF216
Alias:
E3 ubiquitin ligase TRIAD3; EC 6.3.2.-; Ring finger protein 216; RN216; TRIAD3; U7I1; UB7I1; Ubiquitin conjugating enzyme 7-interacting protein 1; ZIN; Zinc finger protein inhibiting NF-kappa-B
Type:
Ligase; EC 6.3.2.-; Ubiquitin conjugating system
Mass (Da):
99406
Number AA:
866
UniProt ID:
Q9NWF9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0044419
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
N
L
R
D
G
P
I
T
I
S
D
S
S
D
E
Site 2
S35
R
D
G
P
I
T
I
S
D
S
S
D
E
E
R
Site 3
S37
G
P
I
T
I
S
D
S
S
D
E
E
R
I
P
Site 4
S38
P
I
T
I
S
D
S
S
D
E
E
R
I
P
M
Site 5
T48
E
R
I
P
M
L
V
T
P
A
P
Q
Q
H
E
Site 6
T66
L
D
D
D
V
I
L
T
E
D
D
S
E
D
D
Site 7
S70
V
I
L
T
E
D
D
S
E
D
D
Y
G
E
F
Site 8
Y74
E
D
D
S
E
D
D
Y
G
E
F
L
D
L
G
Site 9
S86
D
L
G
P
P
G
I
S
E
F
T
K
P
S
G
Site 10
S104
R
E
P
K
P
G
P
S
H
N
Q
A
A
N
D
Site 11
S117
N
D
I
V
N
P
R
S
E
Q
K
V
I
I
L
Site 12
Y131
L
E
E
G
S
L
L
Y
T
E
S
D
P
L
E
Site 13
T132
E
E
G
S
L
L
Y
T
E
S
D
P
L
E
T
Site 14
S134
G
S
L
L
Y
T
E
S
D
P
L
E
T
Q
N
Site 15
T139
T
E
S
D
P
L
E
T
Q
N
Q
S
S
E
D
Site 16
S143
P
L
E
T
Q
N
Q
S
S
E
D
S
E
T
E
Site 17
S144
L
E
T
Q
N
Q
S
S
E
D
S
E
T
E
L
Site 18
S147
Q
N
Q
S
S
E
D
S
E
T
E
L
L
S
N
Site 19
T149
Q
S
S
E
D
S
E
T
E
L
L
S
N
L
G
Site 20
S153
D
S
E
T
E
L
L
S
N
L
G
E
S
A
A
Site 21
S180
L
D
H
P
Y
F
Q
S
L
N
Q
Q
P
R
E
Site 22
T189
N
Q
Q
P
R
E
I
T
N
Q
V
V
P
Q
E
Site 23
S228
E
P
Q
Q
G
G
I
S
G
P
S
S
P
Q
P
Site 24
S231
Q
G
G
I
S
G
P
S
S
P
Q
P
A
H
P
Site 25
S232
G
G
I
S
G
P
S
S
P
Q
P
A
H
P
L
Site 26
S249
F
E
D
Q
Q
L
A
S
D
D
E
E
P
G
P
Site 27
S263
P
A
F
P
M
Q
E
S
Q
E
P
N
L
E
N
Site 28
T291
V
E
L
L
V
K
E
T
E
A
R
F
P
D
V
Site 29
Y313
I
I
H
F
K
N
Y
Y
D
L
N
V
L
C
N
Site 30
Y328
F
L
L
E
N
P
D
Y
P
K
R
E
D
R
I
Site 31
S340
D
R
I
I
I
N
P
S
S
S
L
L
A
S
Q
Site 32
S341
R
I
I
I
N
P
S
S
S
L
L
A
S
Q
D
Site 33
S346
P
S
S
S
L
L
A
S
Q
D
E
T
K
L
P
Site 34
T350
L
L
A
S
Q
D
E
T
K
L
P
K
I
D
F
Site 35
Y360
P
K
I
D
F
F
D
Y
S
K
L
T
P
L
D
Site 36
S361
K
I
D
F
F
D
Y
S
K
L
T
P
L
D
Q
Site 37
T364
F
F
D
Y
S
K
L
T
P
L
D
Q
R
C
F
Site 38
S387
A
D
F
K
V
L
S
S
Q
D
I
K
W
A
L
Site 39
Y401
L
H
E
L
K
G
H
Y
A
I
T
R
K
A
L
Site 40
S419
I
K
K
W
Q
E
L
S
P
E
T
S
G
K
R
Site 41
S423
Q
E
L
S
P
E
T
S
G
K
R
K
K
R
K
Site 42
Y437
K
Q
M
N
Q
Y
S
Y
I
D
F
K
F
E
Q
Site 43
S465
N
K
R
R
H
C
R
S
Y
D
R
R
A
L
L
Site 44
Y466
K
R
R
H
C
R
S
Y
D
R
R
A
L
L
P
Site 45
Y482
V
Q
Q
E
Q
E
F
Y
E
Q
K
I
K
E
M
Site 46
Y506
L
Q
M
N
E
E
Q
Y
Q
K
D
G
Q
L
I
Site 47
Y519
L
I
E
C
R
C
C
Y
G
E
F
P
F
E
E
Site 48
T528
E
F
P
F
E
E
L
T
Q
C
A
D
A
H
L
Site 49
S558
G
S
G
K
L
E
L
S
C
M
E
G
S
C
T
Site 50
T565
S
C
M
E
G
S
C
T
C
S
F
P
T
S
E
Site 51
S567
M
E
G
S
C
T
C
S
F
P
T
S
E
L
E
Site 52
Y585
P
Q
T
I
L
Y
K
Y
Y
E
R
K
A
E
E
Site 53
Y586
Q
T
I
L
Y
K
Y
Y
E
R
K
A
E
E
E
Site 54
S616
S
F
P
A
L
L
D
S
D
V
K
R
F
S
C
Site 55
S622
D
S
D
V
K
R
F
S
C
P
N
P
H
C
R
Site 56
T632
N
P
H
C
R
K
E
T
C
R
K
C
Q
G
L
Site 57
Y659
A
E
K
D
D
I
K
Y
R
T
S
I
E
E
K
Site 58
S662
D
D
I
K
Y
R
T
S
I
E
E
K
M
T
A
Site 59
T668
T
S
I
E
E
K
M
T
A
A
R
I
R
K
C
Site 60
S685
C
G
T
G
L
I
K
S
E
G
C
N
R
M
S
Site 61
S719
H
F
C
Q
H
P
R
S
P
G
A
P
C
Q
E
Site 62
T737
C
S
L
W
T
D
P
T
E
D
D
E
K
L
I
Site 63
T763
K
R
K
N
G
E
N
T
F
K
R
I
G
P
P
Site 64
Y800
P
Q
P
Q
M
P
P
Y
A
F
A
H
P
P
F
Site 65
Y841
L
P
N
V
R
V
N
Y
D
F
G
P
I
H
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation