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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAK1IP1
Full Name:
p21-activated protein kinase-interacting protein 1
Alias:
BA421M1.5; FLJ20624; MAK11; PAK/PLC-interacting protein 1; PAK1 interacting protein 1; PAK1-interacting protein 1; PIP1; PK1IP; WD repeat-containing protein 84; WDR84
Type:
Inhibitor protein
Mass (Da):
43964
Number AA:
392
UniProt ID:
Q9NWT1
International Prot ID:
IPI00549540
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0009968
GO:0009968
GO:0048519
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S46
H
A
H
T
A
S
L
S
A
V
A
V
N
S
R
Site 2
S59
S
R
F
V
V
T
G
S
K
D
E
T
I
H
I
Site 3
T63
V
T
G
S
K
D
E
T
I
H
I
Y
D
M
K
Site 4
Y67
K
D
E
T
I
H
I
Y
D
M
K
K
K
I
E
Site 5
T86
V
H
H
S
G
T
I
T
C
L
K
F
Y
G
N
Site 6
S98
Y
G
N
R
H
L
I
S
G
A
E
D
G
L
I
Site 7
S118
K
K
W
E
C
L
K
S
I
K
A
H
K
G
Q
Site 8
T127
K
A
H
K
G
Q
V
T
F
L
S
I
H
P
S
Site 9
S130
K
G
Q
V
T
F
L
S
I
H
P
S
G
K
L
Site 10
S140
P
S
G
K
L
A
L
S
V
G
T
D
K
T
L
Site 11
T146
L
S
V
G
T
D
K
T
L
R
T
W
N
L
V
Site 12
Y179
W
S
P
R
G
E
Q
Y
V
V
I
I
Q
N
K
Site 13
Y190
I
Q
N
K
I
D
I
Y
Q
L
D
T
A
S
I
Site 14
S198
Q
L
D
T
A
S
I
S
G
T
I
T
N
E
K
Site 15
T200
D
T
A
S
I
S
G
T
I
T
N
E
K
R
I
Site 16
T202
A
S
I
S
G
T
I
T
N
E
K
R
I
S
S
Site 17
S208
I
T
N
E
K
R
I
S
S
V
K
F
L
S
E
Site 18
S209
T
N
E
K
R
I
S
S
V
K
F
L
S
E
S
Site 19
S214
I
S
S
V
K
F
L
S
E
S
V
L
A
V
A
Site 20
S285
Q
D
K
K
V
P
P
S
L
L
C
E
I
N
T
Site 21
S320
L
P
P
A
A
E
P
S
P
V
S
K
E
Q
S
Site 22
S323
A
A
E
P
S
P
V
S
K
E
Q
S
K
I
G
Site 23
S327
S
P
V
S
K
E
Q
S
K
I
G
K
K
E
P
Site 24
T337
G
K
K
E
P
G
D
T
V
H
K
E
E
K
R
Site 25
S345
V
H
K
E
E
K
R
S
K
P
N
T
K
K
R
Site 26
T349
E
K
R
S
K
P
N
T
K
K
R
G
L
T
G
Site 27
T355
N
T
K
K
R
G
L
T
G
D
S
K
K
A
T
Site 28
S358
K
R
G
L
T
G
D
S
K
K
A
T
K
E
S
Site 29
T362
T
G
D
S
K
K
A
T
K
E
S
G
L
I
S
Site 30
S365
S
K
K
A
T
K
E
S
G
L
I
S
T
K
K
Site 31
S369
T
K
E
S
G
L
I
S
T
K
K
R
K
M
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation