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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NLRP2
Full Name:
NACHT, LRR and PYD domains-containing protein 2
Alias:
Nucleotide-binding site protein 1;PYRIN domain and NACHT domain-containing protein 1;PYRIN-containing APAF1-like protein 2
Type:
Mass (Da):
120515
Number AA:
1062
UniProt ID:
Q9NX02
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
Q
A
L
L
E
Q
L
S
Q
D
E
L
S
K
F
Site 2
S24
Q
L
S
Q
D
E
L
S
K
F
K
Y
L
I
T
Site 3
T31
S
K
F
K
Y
L
I
T
T
F
S
L
A
H
E
Site 4
S34
K
Y
L
I
T
T
F
S
L
A
H
E
L
Q
K
Site 5
S85
K
M
H
R
M
D
L
S
E
R
A
K
D
E
V
Site 6
S99
V
R
E
A
A
L
K
S
F
N
K
R
K
P
L
Site 7
S107
F
N
K
R
K
P
L
S
L
G
I
T
R
K
E
Site 8
T111
K
P
L
S
L
G
I
T
R
K
E
R
P
P
L
Site 9
T129
E
M
L
E
R
F
K
T
E
A
Q
A
F
T
E
Site 10
T135
K
T
E
A
Q
A
F
T
E
T
K
G
N
V
I
Site 11
Y162
D
K
D
N
R
C
R
Y
I
L
K
T
K
F
R
Site 12
S174
K
F
R
E
M
W
K
S
W
P
G
D
S
K
E
Site 13
Y189
V
Q
V
M
A
E
R
Y
K
M
L
I
P
F
S
Site 14
Y241
N
L
I
H
K
F
K
Y
A
F
Y
L
S
C
R
Site 15
Y244
H
K
F
K
Y
A
F
Y
L
S
C
R
E
L
S
Site 16
S246
F
K
Y
A
F
Y
L
S
C
R
E
L
S
R
L
Site 17
S251
Y
L
S
C
R
E
L
S
R
L
G
P
C
S
F
Site 18
T335
P
K
A
A
L
L
V
T
T
R
P
R
A
L
R
Site 19
Y367
L
E
E
D
R
R
A
Y
F
L
R
H
F
G
D
Site 20
S463
Q
G
L
W
A
Q
T
S
V
L
H
R
E
D
L
Site 21
S478
E
R
L
G
V
Q
E
S
D
L
R
L
F
L
D
Site 22
S495
I
L
R
Q
D
R
V
S
K
G
C
Y
S
F
I
Site 23
Y499
D
R
V
S
K
G
C
Y
S
F
I
H
L
S
F
Site 24
S500
R
V
S
K
G
C
Y
S
F
I
H
L
S
F
Q
Site 25
T529
E
E
D
R
D
G
H
T
W
D
I
G
D
V
Q
Site 26
S540
G
D
V
Q
K
L
L
S
G
V
E
R
L
R
N
Site 27
S557
L
I
Q
A
G
Y
Y
S
F
G
L
A
N
E
K
Site 28
T572
R
A
K
E
L
E
A
T
F
G
C
R
M
S
P
Site 29
S578
A
T
F
G
C
R
M
S
P
D
I
K
Q
E
L
Site 30
S591
E
L
L
R
C
D
I
S
C
K
G
G
H
S
T
Site 31
T598
S
C
K
G
G
H
S
T
V
T
D
L
Q
E
L
Site 32
T600
K
G
G
H
S
T
V
T
D
L
Q
E
L
L
G
Site 33
Y610
Q
E
L
L
G
C
L
Y
E
S
Q
E
E
E
L
Site 34
S612
L
L
G
C
L
Y
E
S
Q
E
E
E
L
V
K
Site 35
S654
C
R
N
L
Q
K
M
S
L
Q
V
I
K
E
N
Site 36
T667
E
N
L
P
E
N
V
T
A
S
E
S
D
A
E
Site 37
S671
E
N
V
T
A
S
E
S
D
A
E
V
E
R
S
Site 38
S678
S
D
A
E
V
E
R
S
Q
D
D
Q
H
M
L
Site 39
S739
R
V
V
F
K
N
I
S
P
A
D
A
H
R
N
Site 40
Y759
R
G
H
K
T
V
T
Y
L
T
L
Q
G
N
D
Site 41
Y787
H
P
E
C
N
L
R
Y
L
G
L
V
S
C
S
Site 42
S804
T
Q
Q
W
A
D
L
S
L
A
L
E
V
N
Q
Site 43
T814
L
E
V
N
Q
S
L
T
C
V
N
L
S
D
N
Site 44
S819
S
L
T
C
V
N
L
S
D
N
E
L
L
D
E
Site 45
Y832
D
E
G
A
K
L
L
Y
T
T
L
R
H
P
K
Site 46
T833
E
G
A
K
L
L
Y
T
T
L
R
H
P
K
C
Site 47
T834
G
A
K
L
L
Y
T
T
L
R
H
P
K
C
F
Site 48
S846
K
C
F
L
Q
R
L
S
L
E
N
C
H
L
T
Site 49
Y894
F
L
C
E
G
L
R
Y
P
E
C
K
L
Q
T
Site 50
T918
S
D
G
C
C
D
L
T
K
L
L
Q
E
K
S
Site 51
S976
F
S
C
E
D
L
C
S
A
L
S
C
N
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation