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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DUS2L
Full Name:
tRNA-dihydrouridine synthase 2-like
Alias:
Dihydrouridine synthase 2-like; Dihydrouridine synthase 2-like (SMM1, S. cerevisiae); Dihydrouridine synthase 2-like, SMM1; Dihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae); DUS2; FLJ20399; HDUS2; SMM1; TRNA-dihydrouridine synthase 2-like; Up-regulated in lung cancer; Up-regulated in lung cancer 8; URLC8
Type:
Oxidoreductase; EC 1.-.-.-; RNA binding protein
Mass (Da):
55050
Number AA:
493
UniProt ID:
Q9NX74
International Prot ID:
IPI00015804
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005737
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006396
GO:0006399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
I
L
N
S
L
S
L
C
Y
H
N
Site 2
Y10
L
N
S
L
S
L
C
Y
H
N
K
L
I
L
A
Site 3
T24
A
P
M
V
R
V
G
T
L
P
M
R
L
L
A
Site 4
T76
D
D
R
V
V
F
R
T
C
E
R
E
Q
N
R
Site 5
Y120
N
M
G
C
P
K
Q
Y
S
T
K
G
G
M
G
Site 6
S121
M
G
C
P
K
Q
Y
S
T
K
G
G
M
G
A
Site 7
S132
G
M
G
A
A
L
L
S
D
P
D
K
I
E
K
Site 8
S142
D
K
I
E
K
I
L
S
T
L
V
K
G
T
R
Site 9
T148
L
S
T
L
V
K
G
T
R
R
P
V
T
C
K
Site 10
T153
K
G
T
R
R
P
V
T
C
K
I
R
I
L
P
Site 11
S167
P
S
L
E
D
T
L
S
L
V
K
R
I
E
R
Site 12
S196
E
R
P
Q
H
P
V
S
C
E
V
I
K
A
I
Site 13
Y224
S
H
D
H
I
Q
Q
Y
S
D
I
E
D
F
R
Site 14
T234
I
E
D
F
R
Q
A
T
A
A
S
S
V
M
V
Site 15
Y267
L
E
E
V
M
Q
K
Y
I
R
Y
A
V
Q
Y
Site 16
Y274
Y
I
R
Y
A
V
Q
Y
D
N
H
Y
T
N
T
Site 17
Y278
A
V
Q
Y
D
N
H
Y
T
N
T
K
Y
C
L
Site 18
Y283
N
H
Y
T
N
T
K
Y
C
L
C
Q
M
L
R
Site 19
S295
M
L
R
E
Q
L
E
S
P
Q
G
R
L
L
H
Site 20
S306
R
L
L
H
A
A
Q
S
S
R
E
I
C
E
A
Site 21
Y320
A
F
G
L
G
A
F
Y
E
E
T
T
Q
E
L
Site 22
S335
D
A
Q
Q
A
R
L
S
A
K
T
S
E
Q
T
Site 23
T338
Q
A
R
L
S
A
K
T
S
E
Q
T
G
E
P
Site 24
S339
A
R
L
S
A
K
T
S
E
Q
T
G
E
P
A
Site 25
T349
T
G
E
P
A
E
D
T
S
G
V
I
K
M
A
Site 26
Y364
V
K
F
D
R
R
A
Y
P
A
Q
I
T
P
K
Site 27
T369
R
A
Y
P
A
Q
I
T
P
K
M
C
L
L
E
Site 28
Y388
E
K
L
A
Q
P
V
Y
E
T
V
Q
R
P
L
Site 29
T404
R
L
F
S
S
I
V
T
V
A
E
Q
K
Y
Q
Site 30
Y410
V
T
V
A
E
Q
K
Y
Q
S
T
L
W
D
K
Site 31
T413
A
E
Q
K
Y
Q
S
T
L
W
D
K
S
K
K
Site 32
S418
Q
S
T
L
W
D
K
S
K
K
L
A
E
Q
A
Site 33
S445
E
G
R
L
G
E
E
S
P
S
L
H
K
R
K
Site 34
S447
R
L
G
E
E
S
P
S
L
H
K
R
K
R
E
Site 35
S484
K
P
F
V
A
L
G
S
G
E
E
S
P
L
E
Site 36
S488
A
L
G
S
G
E
E
S
P
L
E
G
W
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation