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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKS1
Full Name:
Meckel syndrome type 1 protein
Alias:
Type:
Mass (Da):
64528
Number AA:
559
UniProt ID:
Q9NXB0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T34
R
V
H
L
Q
R
I
T
S
S
N
F
L
H
Y
Site 2
S35
V
H
L
Q
R
I
T
S
S
N
F
L
H
Y
Q
Site 3
T56
K
D
L
I
D
L
A
T
F
R
P
Q
P
T
A
Site 4
S86
G
W
Q
E
K
L
F
S
Q
F
E
V
D
L
Y
Site 5
Y93
S
Q
F
E
V
D
L
Y
Q
N
E
T
A
C
Q
Site 6
T97
V
D
L
Y
Q
N
E
T
A
C
Q
S
P
L
D
Site 7
S101
Q
N
E
T
A
C
Q
S
P
L
D
Y
Q
Y
R
Site 8
Y105
A
C
Q
S
P
L
D
Y
Q
Y
R
Q
E
I
L
Site 9
Y107
Q
S
P
L
D
Y
Q
Y
R
Q
E
I
L
K
L
Site 10
S117
E
I
L
K
L
E
N
S
G
G
K
K
N
R
R
Site 11
T127
K
K
N
R
R
I
F
T
Y
T
D
S
D
R
Y
Site 12
Y128
K
N
R
R
I
F
T
Y
T
D
S
D
R
Y
T
Site 13
T129
N
R
R
I
F
T
Y
T
D
S
D
R
Y
T
N
Site 14
S131
R
I
F
T
Y
T
D
S
D
R
Y
T
N
L
E
Site 15
Y134
T
Y
T
D
S
D
R
Y
T
N
L
E
E
H
C
Site 16
T145
E
E
H
C
Q
R
M
T
T
A
A
S
E
V
P
Site 17
T146
E
H
C
Q
R
M
T
T
A
A
S
E
V
P
S
Site 18
S179
M
E
G
G
I
L
K
S
R
I
V
T
W
E
P
Site 19
T183
I
L
K
S
R
I
V
T
W
E
P
S
E
E
F
Site 20
T199
R
N
N
H
V
I
N
T
P
L
Q
T
M
H
I
Site 21
Y221
K
K
L
G
Y
K
K
Y
E
H
V
L
C
T
L
Site 22
T227
K
Y
E
H
V
L
C
T
L
K
V
D
S
N
G
Site 23
T237
V
D
S
N
G
V
I
T
V
K
P
D
F
T
G
Site 24
T243
I
T
V
K
P
D
F
T
G
L
K
G
P
Y
R
Site 25
T253
K
G
P
Y
R
I
E
T
E
G
E
K
Q
E
L
Site 26
Y263
E
K
Q
E
L
W
K
Y
T
I
D
N
V
S
P
Site 27
S269
K
Y
T
I
D
N
V
S
P
H
A
Q
P
E
E
Site 28
Y288
R
R
V
F
K
D
L
Y
G
R
H
K
E
Y
L
Site 29
Y294
L
Y
G
R
H
K
E
Y
L
S
S
L
V
G
T
Site 30
S296
G
R
H
K
E
Y
L
S
S
L
V
G
T
D
F
Site 31
S297
R
H
K
E
Y
L
S
S
L
V
G
T
D
F
E
Site 32
T301
Y
L
S
S
L
V
G
T
D
F
E
M
T
V
P
Site 33
Y325
E
V
V
S
A
Q
G
Y
E
Y
D
N
L
Y
V
Site 34
Y327
V
S
A
Q
G
Y
E
Y
D
N
L
Y
V
H
F
Site 35
Y331
G
Y
E
Y
D
N
L
Y
V
H
F
F
V
E
L
Site 36
T340
H
F
F
V
E
L
P
T
A
H
W
S
S
P
A
Site 37
S345
L
P
T
A
H
W
S
S
P
A
F
Q
Q
L
S
Site 38
S352
S
P
A
F
Q
Q
L
S
G
V
T
Q
T
C
T
Site 39
S362
T
Q
T
C
T
T
K
S
L
A
M
D
K
V
A
Site 40
Y373
D
K
V
A
H
F
S
Y
P
F
T
F
E
A
F
Site 41
S387
F
F
L
H
E
D
E
S
S
D
A
L
P
E
W
Site 42
S388
F
L
H
E
D
E
S
S
D
A
L
P
E
W
P
Site 43
Y410
S
L
D
F
W
Q
R
Y
R
V
E
G
Y
G
A
Site 44
T428
P
A
T
P
G
S
H
T
L
T
V
S
T
W
R
Site 45
T430
T
P
G
S
H
T
L
T
V
S
T
W
R
P
V
Site 46
S432
G
S
H
T
L
T
V
S
T
W
R
P
V
E
L
Site 47
T433
S
H
T
L
T
V
S
T
W
R
P
V
E
L
G
Site 48
S460
S
L
E
L
E
D
L
S
Y
V
R
I
P
G
S
Site 49
Y461
L
E
L
E
D
L
S
Y
V
R
I
P
G
S
F
Site 50
S467
S
Y
V
R
I
P
G
S
F
K
G
E
R
L
S
Site 51
S474
S
F
K
G
E
R
L
S
R
F
G
L
R
T
E
Site 52
T480
L
S
R
F
G
L
R
T
E
T
T
G
T
V
T
Site 53
T482
R
F
G
L
R
T
E
T
T
G
T
V
T
F
R
Site 54
T485
L
R
T
E
T
T
G
T
V
T
F
R
L
H
C
Site 55
T487
T
E
T
T
G
T
V
T
F
R
L
H
C
L
Q
Site 56
S496
R
L
H
C
L
Q
Q
S
R
A
F
M
E
S
S
Site 57
S502
Q
S
R
A
F
M
E
S
S
S
L
Q
K
R
M
Site 58
S504
R
A
F
M
E
S
S
S
L
Q
K
R
M
R
S
Site 59
S511
S
L
Q
K
R
M
R
S
V
L
D
R
L
E
G
Site 60
S520
L
D
R
L
E
G
F
S
Q
Q
S
S
I
H
N
Site 61
S524
E
G
F
S
Q
Q
S
S
I
H
N
V
L
E
A
Site 62
S545
R
M
Q
E
A
R
E
S
L
P
Q
D
L
V
S
Site 63
S554
P
Q
D
L
V
S
P
S
G
T
L
V
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation