KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MIOS
Full Name:
WD repeat-containing protein mio
Alias:
DKFZp434J087; FLJ20323; Missing oocyte, meiosis regulator,
Type:
Unknown function
Mass (Da):
98584
Number AA:
875
UniProt ID:
Q9NXC5
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
G
T
K
P
D
I
L
Site 2
Y28
C
D
S
E
L
S
L
Y
H
V
E
S
T
V
N
Site 3
S32
L
S
L
Y
H
V
E
S
T
V
N
S
E
L
K
Site 4
T33
S
L
Y
H
V
E
S
T
V
N
S
E
L
K
A
Site 5
S36
H
V
E
S
T
V
N
S
E
L
K
A
G
S
L
Site 6
S42
N
S
E
L
K
A
G
S
L
R
L
S
E
D
S
Site 7
S46
K
A
G
S
L
R
L
S
E
D
S
A
A
T
L
Site 8
S55
D
S
A
A
T
L
L
S
I
N
S
D
T
P
Y
Site 9
S58
A
T
L
L
S
I
N
S
D
T
P
Y
M
K
C
Site 10
Y62
S
I
N
S
D
T
P
Y
M
K
C
V
A
W
Y
Site 11
S91
N
G
R
V
V
L
T
S
L
G
Q
D
H
N
S
Site 12
S98
S
L
G
Q
D
H
N
S
K
F
K
D
L
I
G
Site 13
S164
P
M
E
K
V
K
L
S
A
G
E
T
E
T
T
Site 14
T171
S
A
G
E
T
E
T
T
L
L
V
T
K
P
L
Site 15
Y179
L
L
V
T
K
P
L
Y
E
L
G
Q
N
D
A
Site 16
T216
A
I
F
D
L
R
N
T
S
Q
K
M
F
V
N
Site 17
T231
T
K
A
V
Q
G
V
T
V
D
P
Y
F
H
D
Site 18
Y235
Q
G
V
T
V
D
P
Y
F
H
D
R
V
A
S
Site 19
S242
Y
F
H
D
R
V
A
S
F
Y
E
G
Q
V
A
Site 20
Y244
H
D
R
V
A
S
F
Y
E
G
Q
V
A
I
W
Site 21
T262
K
F
E
K
P
V
L
T
L
T
E
Q
P
K
P
Site 22
T264
E
K
P
V
L
T
L
T
E
Q
P
K
P
L
T
Site 23
T271
T
E
Q
P
K
P
L
T
K
V
A
W
C
P
T
Site 24
T280
V
A
W
C
P
T
R
T
G
L
L
A
T
L
T
Site 25
T285
T
R
T
G
L
L
A
T
L
T
R
D
S
N
I
Site 26
S290
L
A
T
L
T
R
D
S
N
I
I
R
L
Y
D
Site 27
Y296
D
S
N
I
I
R
L
Y
D
M
Q
H
T
P
T
Site 28
T301
R
L
Y
D
M
Q
H
T
P
T
P
I
G
D
E
Site 29
T303
Y
D
M
Q
H
T
P
T
P
I
G
D
E
T
E
Site 30
T309
P
T
P
I
G
D
E
T
E
P
T
I
I
E
R
Site 31
T312
I
G
D
E
T
E
P
T
I
I
E
R
S
V
Q
Site 32
T342
Q
N
R
M
I
V
V
T
P
N
R
T
M
S
D
Site 33
S348
V
T
P
N
R
T
M
S
D
F
T
V
F
E
R
Site 34
T351
N
R
T
M
S
D
F
T
V
F
E
R
I
S
L
Site 35
Y375
W
A
C
G
R
H
L
Y
E
C
T
E
E
E
N
Site 36
S385
T
E
E
E
N
D
N
S
L
E
K
D
I
A
T
Site 37
T392
S
L
E
K
D
I
A
T
K
M
R
L
R
A
L
Site 38
S400
K
M
R
L
R
A
L
S
R
Y
G
L
D
T
E
Site 39
Y402
R
L
R
A
L
S
R
Y
G
L
D
T
E
Q
V
Site 40
T406
L
S
R
Y
G
L
D
T
E
Q
V
W
R
N
H
Site 41
Y428
P
Q
L
K
S
L
W
Y
T
L
H
F
M
K
Q
Site 42
Y436
T
L
H
F
M
K
Q
Y
T
E
D
M
D
Q
K
Site 43
S444
T
E
D
M
D
Q
K
S
P
G
N
K
G
S
L
Site 44
S450
K
S
P
G
N
K
G
S
L
V
Y
A
G
I
K
Site 45
Y453
G
N
K
G
S
L
V
Y
A
G
I
K
S
I
V
Site 46
S469
S
S
L
G
M
V
E
S
S
R
H
N
W
S
G
Site 47
S470
S
L
G
M
V
E
S
S
R
H
N
W
S
G
L
Site 48
S475
E
S
S
R
H
N
W
S
G
L
D
K
Q
S
D
Site 49
S514
D
V
G
P
F
L
N
S
L
V
Q
E
G
E
W
Site 50
S547
I
L
N
E
G
A
S
S
E
K
G
D
L
N
L
Site 51
S577
S
L
W
R
E
M
C
S
T
L
R
L
Q
L
N
Site 52
T578
L
W
R
E
M
C
S
T
L
R
L
Q
L
N
N
Site 53
S601
F
L
T
S
E
T
G
S
Y
D
G
V
L
Y
E
Site 54
Y602
L
T
S
E
T
G
S
Y
D
G
V
L
Y
E
N
Site 55
Y607
G
S
Y
D
G
V
L
Y
E
N
K
V
A
V
R
Site 56
S625
A
F
A
C
K
F
L
S
D
T
Q
L
N
R
Y
Site 57
T627
A
C
K
F
L
S
D
T
Q
L
N
R
Y
I
E
Site 58
Y632
S
D
T
Q
L
N
R
Y
I
E
K
L
T
N
E
Site 59
S664
D
G
V
D
L
M
E
S
Y
V
D
R
T
G
D
Site 60
Y665
G
V
D
L
M
E
S
Y
V
D
R
T
G
D
V
Site 61
T674
D
R
T
G
D
V
Q
T
A
S
Y
C
M
L
Q
Site 62
S676
T
G
D
V
Q
T
A
S
Y
C
M
L
Q
G
S
Site 63
Y677
G
D
V
Q
T
A
S
Y
C
M
L
Q
G
S
P
Site 64
S683
S
Y
C
M
L
Q
G
S
P
L
D
V
L
K
D
Site 65
Y695
L
K
D
E
R
V
Q
Y
W
I
E
N
Y
R
N
Site 66
S721
A
E
F
D
I
H
R
S
K
L
D
P
S
S
K
Site 67
S726
H
R
S
K
L
D
P
S
S
K
P
L
A
Q
V
Site 68
S727
R
S
K
L
D
P
S
S
K
P
L
A
Q
V
F
Site 69
S747
C
G
K
S
I
S
Y
S
C
S
A
V
P
H
Q
Site 70
S749
K
S
I
S
Y
S
C
S
A
V
P
H
Q
G
R
Site 71
S759
P
H
Q
G
R
G
F
S
Q
Y
G
V
S
G
S
Site 72
Y761
Q
G
R
G
F
S
Q
Y
G
V
S
G
S
P
T
Site 73
S764
G
F
S
Q
Y
G
V
S
G
S
P
T
K
S
K
Site 74
S766
S
Q
Y
G
V
S
G
S
P
T
K
S
K
V
T
Site 75
T768
Y
G
V
S
G
S
P
T
K
S
K
V
T
S
C
Site 76
S770
V
S
G
S
P
T
K
S
K
V
T
S
C
P
G
Site 77
T773
S
P
T
K
S
K
V
T
S
C
P
G
C
R
K
Site 78
S774
P
T
K
S
K
V
T
S
C
P
G
C
R
K
P
Site 79
S797
I
N
M
G
T
P
V
S
S
C
P
G
G
T
K
Site 80
S798
N
M
G
T
P
V
S
S
C
P
G
G
T
K
S
Site 81
S805
S
C
P
G
G
T
K
S
D
E
K
V
D
L
S
Site 82
S812
S
D
E
K
V
D
L
S
K
D
K
K
L
A
Q
Site 83
T864
K
C
M
Q
L
D
T
T
G
N
L
V
P
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation