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Updated November 2019
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Protein Info
Short Name:
CNTLN
Full Name:
Centlein
Alias:
Centrosomal protein
Type:
Mass (Da):
161597
Number AA:
1405
UniProt ID:
Q9NXG0
International Prot ID:
IPI00657839
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016020
GO:0044464
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0000155
GO:0003824
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0007165
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
A
R
S
P
P
S
P
H
P
S
Site 2
S8
M
A
A
R
S
P
P
S
P
H
P
S
P
P
A
Site 3
S12
S
P
P
S
P
H
P
S
P
P
A
R
Q
L
G
Site 4
S22
A
R
Q
L
G
P
R
S
P
R
V
G
R
G
A
Site 5
S36
A
E
V
H
A
M
R
S
E
A
S
G
F
A
G
Site 6
S53
R
E
V
V
A
D
E
S
D
K
I
W
V
G
E
Site 7
S63
I
W
V
G
E
E
G
S
G
G
R
R
G
P
G
Site 8
S81
P
A
H
A
P
L
L
S
A
P
M
G
S
R
R
Site 9
S86
L
L
S
A
P
M
G
S
R
R
L
E
G
I
S
Site 10
S93
S
R
R
L
E
G
I
S
V
E
E
A
M
V
T
Site 11
T100
S
V
E
E
A
M
V
T
R
T
Q
L
L
E
E
Site 12
S110
Q
L
L
E
E
E
L
S
S
L
K
E
E
L
A
Site 13
S111
L
L
E
E
E
L
S
S
L
K
E
E
L
A
L
Site 14
S145
P
D
L
T
Q
V
V
S
L
V
V
E
R
E
K
Site 15
S155
V
E
R
E
K
Q
K
S
E
A
K
D
R
K
V
Site 16
S181
Q
E
F
E
Q
R
E
S
V
L
K
Q
E
I
N
Site 17
S209
A
F
L
R
K
E
F
S
D
L
E
K
K
F
K
Site 18
S219
E
K
K
F
K
D
K
S
Q
E
I
K
D
T
K
Site 19
T225
K
S
Q
E
I
K
D
T
K
E
C
V
Q
N
K
Site 20
S251
E
E
E
N
K
K
L
S
T
R
C
T
D
L
L
Site 21
T255
K
K
L
S
T
R
C
T
D
L
L
N
D
L
E
Site 22
Y276
A
H
L
R
K
E
K
Y
S
T
D
A
K
I
K
Site 23
S277
H
L
R
K
E
K
Y
S
T
D
A
K
I
K
T
Site 24
T278
L
R
K
E
K
Y
S
T
D
A
K
I
K
T
F
Site 25
T284
S
T
D
A
K
I
K
T
F
E
D
N
L
I
E
Site 26
S299
A
R
K
E
V
E
V
S
Q
S
K
Y
N
A
L
Site 27
S301
K
E
V
E
V
S
Q
S
K
Y
N
A
L
S
L
Site 28
Y303
V
E
V
S
Q
S
K
Y
N
A
L
S
L
Q
L
Site 29
S307
Q
S
K
Y
N
A
L
S
L
Q
L
S
N
K
Q
Site 30
S311
N
A
L
S
L
Q
L
S
N
K
Q
T
E
L
I
Site 31
T325
I
Q
K
D
M
D
I
T
L
V
R
K
E
L
Q
Site 32
Y338
L
Q
E
L
Q
N
L
Y
K
Q
N
S
T
H
T
Site 33
T362
L
Q
V
L
N
M
D
T
Q
K
V
L
R
N
Q
Site 34
T374
R
N
Q
E
D
V
H
T
A
E
S
I
S
Y
Q
Site 35
Y380
H
T
A
E
S
I
S
Y
Q
K
L
Y
N
E
L
Site 36
Y384
S
I
S
Y
Q
K
L
Y
N
E
L
H
I
C
F
Site 37
S404
N
E
A
M
L
R
Q
S
V
T
N
L
Q
D
Q
Site 38
S429
L
K
E
K
L
Q
E
S
Q
G
A
P
L
P
L
Site 39
S440
P
L
P
L
P
Q
E
S
D
P
D
Y
S
A
Q
Site 40
Y444
P
Q
E
S
D
P
D
Y
S
A
Q
V
P
H
R
Site 41
S453
A
Q
V
P
H
R
P
S
L
S
S
L
E
T
L
Site 42
S456
P
H
R
P
S
L
S
S
L
E
T
L
M
V
S
Site 43
T459
P
S
L
S
S
L
E
T
L
M
V
S
Q
K
S
Site 44
S463
S
L
E
T
L
M
V
S
Q
K
S
E
I
E
Y
Site 45
Y470
S
Q
K
S
E
I
E
Y
L
Q
E
K
L
K
I
Site 46
S483
K
I
A
N
E
K
L
S
E
N
I
S
A
N
K
Site 47
S487
E
K
L
S
E
N
I
S
A
N
K
G
F
S
R
Site 48
S496
N
K
G
F
S
R
K
S
I
M
T
S
A
E
G
Site 49
T499
F
S
R
K
S
I
M
T
S
A
E
G
K
H
K
Site 50
S500
S
R
K
S
I
M
T
S
A
E
G
K
H
K
E
Site 51
S513
K
E
P
P
V
K
R
S
R
S
L
S
P
K
S
Site 52
S515
P
P
V
K
R
S
R
S
L
S
P
K
S
S
F
Site 53
S517
V
K
R
S
R
S
L
S
P
K
S
S
F
T
D
Site 54
S520
S
R
S
L
S
P
K
S
S
F
T
D
S
E
E
Site 55
S521
R
S
L
S
P
K
S
S
F
T
D
S
E
E
L
Site 56
T523
L
S
P
K
S
S
F
T
D
S
E
E
L
Q
K
Site 57
S525
P
K
S
S
F
T
D
S
E
E
L
Q
K
L
R
Site 58
S549
E
K
A
L
Q
L
K
S
Q
E
N
D
E
L
R
Site 59
T571
E
R
L
Q
M
L
Q
T
N
Y
R
A
V
K
E
Site 60
Y573
L
Q
M
L
Q
T
N
Y
R
A
V
K
E
Q
L
Site 61
S608
Q
Q
L
R
Q
E
D
S
D
A
V
W
N
E
L
Site 62
Y617
A
V
W
N
E
L
A
Y
F
K
R
E
N
Q
E
Site 63
S644
D
E
L
K
V
H
I
S
I
D
K
A
A
I
Q
Site 64
S668
R
E
E
Q
L
F
R
S
G
E
D
D
E
V
K
Site 65
S677
E
D
D
E
V
K
R
S
T
P
E
K
N
G
K
Site 66
T678
D
D
E
V
K
R
S
T
P
E
K
N
G
K
E
Site 67
T690
G
K
E
M
L
E
Q
T
L
Q
K
V
I
E
L
Site 68
S703
E
L
E
N
R
L
K
S
F
E
K
R
S
R
K
Site 69
S727
K
E
N
D
F
L
K
S
L
L
K
Q
Q
Q
E
Site 70
T736
L
K
Q
Q
Q
E
D
T
E
T
R
E
K
E
L
Site 71
T738
Q
Q
Q
E
D
T
E
T
R
E
K
E
L
E
Q
Site 72
T758
K
D
V
E
K
E
N
T
E
L
Q
V
K
I
S
Site 73
T769
V
K
I
S
E
L
E
T
E
V
T
S
L
R
R
Site 74
T772
S
E
L
E
T
E
V
T
S
L
R
R
Q
V
A
Site 75
S773
E
L
E
T
E
V
T
S
L
R
R
Q
V
A
E
Site 76
S807
Q
S
A
D
R
A
K
S
E
M
A
T
M
K
V
Site 77
T811
R
A
K
S
E
M
A
T
M
K
V
R
S
G
R
Site 78
Y819
M
K
V
R
S
G
R
Y
D
C
K
T
T
M
T
Site 79
T823
S
G
R
Y
D
C
K
T
T
M
T
K
V
K
F
Site 80
S838
K
A
A
K
K
N
C
S
V
G
R
H
H
T
V
Site 81
T844
C
S
V
G
R
H
H
T
V
L
N
H
S
I
K
Site 82
S869
K
D
G
W
E
D
V
S
E
S
S
S
D
S
E
Site 83
S871
G
W
E
D
V
S
E
S
S
S
D
S
E
A
Q
Site 84
S873
E
D
V
S
E
S
S
S
D
S
E
A
Q
T
S
Site 85
S875
V
S
E
S
S
S
D
S
E
A
Q
T
S
Q
T
Site 86
T879
S
S
D
S
E
A
Q
T
S
Q
T
L
G
T
I
Site 87
S880
S
D
S
E
A
Q
T
S
Q
T
L
G
T
I
I
Site 88
S891
G
T
I
I
V
E
T
S
Q
K
I
S
P
T
E
Site 89
S895
V
E
T
S
Q
K
I
S
P
T
E
D
G
K
D
Site 90
S906
D
G
K
D
Q
K
E
S
D
P
T
E
D
S
Q
Site 91
T909
D
Q
K
E
S
D
P
T
E
D
S
Q
T
Q
G
Site 92
S912
E
S
D
P
T
E
D
S
Q
T
Q
G
K
E
I
Site 93
T914
D
P
T
E
D
S
Q
T
Q
G
K
E
I
V
Q
Site 94
T922
Q
G
K
E
I
V
Q
T
Y
L
N
I
D
G
K
Site 95
Y923
G
K
E
I
V
Q
T
Y
L
N
I
D
G
K
T
Site 96
T930
Y
L
N
I
D
G
K
T
P
K
D
Y
F
H
D
Site 97
Y934
D
G
K
T
P
K
D
Y
F
H
D
K
N
A
K
Site 98
T944
D
K
N
A
K
K
P
T
F
Q
K
K
N
C
K
Site 99
S955
K
N
C
K
M
Q
K
S
S
H
T
A
V
P
T
Site 100
S956
N
C
K
M
Q
K
S
S
H
T
A
V
P
T
R
Site 101
T962
S
S
H
T
A
V
P
T
R
V
N
R
E
K
Y
Site 102
Y969
T
R
V
N
R
E
K
Y
K
N
I
T
A
Q
K
Site 103
T973
R
E
K
Y
K
N
I
T
A
Q
K
S
S
S
N
Site 104
S977
K
N
I
T
A
Q
K
S
S
S
N
I
I
L
L
Site 105
S979
I
T
A
Q
K
S
S
S
N
I
I
L
L
R
E
Site 106
S990
L
L
R
E
R
I
I
S
L
Q
Q
Q
N
S
V
Site 107
S996
I
S
L
Q
Q
Q
N
S
V
L
Q
N
A
K
K
Site 108
S1008
A
K
K
T
A
E
L
S
V
K
E
Y
K
E
V
Site 109
Y1012
A
E
L
S
V
K
E
Y
K
E
V
N
E
K
L
Site 110
S1026
L
L
H
Q
Q
Q
V
S
D
Q
R
F
Q
T
S
Site 111
T1032
V
S
D
Q
R
F
Q
T
S
R
Q
T
I
K
K
Site 112
T1036
R
F
Q
T
S
R
Q
T
I
K
K
L
N
L
D
Site 113
S1060
D
L
L
K
K
L
E
S
S
S
E
I
T
S
L
Site 114
S1061
L
L
K
K
L
E
S
S
S
E
I
T
S
L
A
Site 115
S1062
L
K
K
L
E
S
S
S
E
I
T
S
L
A
E
Site 116
S1066
E
S
S
S
E
I
T
S
L
A
E
E
N
S
Q
Site 117
S1072
T
S
L
A
E
E
N
S
Q
V
T
F
P
R
I
Site 118
T1075
A
E
E
N
S
Q
V
T
F
P
R
I
Q
V
T
Site 119
T1082
T
F
P
R
I
Q
V
T
S
L
S
P
S
R
S
Site 120
S1083
F
P
R
I
Q
V
T
S
L
S
P
S
R
S
M
Site 121
S1085
R
I
Q
V
T
S
L
S
P
S
R
S
M
D
L
Site 122
S1087
Q
V
T
S
L
S
P
S
R
S
M
D
L
E
M
Site 123
S1089
T
S
L
S
P
S
R
S
M
D
L
E
M
K
Q
Site 124
T1109
K
N
A
T
N
E
L
T
K
Q
S
S
N
V
K
Site 125
S1113
N
E
L
T
K
Q
S
S
N
V
K
T
L
K
F
Site 126
T1117
K
Q
S
S
N
V
K
T
L
K
F
E
L
L
A
Site 127
T1144
S
R
M
E
R
D
I
T
M
K
R
H
L
I
E
Site 128
S1163
R
Q
K
V
N
L
E
S
N
K
S
F
S
E
M
Site 129
S1166
V
N
L
E
S
N
K
S
F
S
E
M
L
Q
N
Site 130
S1168
L
E
S
N
K
S
F
S
E
M
L
Q
N
L
D
Site 131
T1180
N
L
D
K
K
V
K
T
L
T
E
E
C
S
N
Site 132
T1182
D
K
K
V
K
T
L
T
E
E
C
S
N
K
K
Site 133
S1186
K
T
L
T
E
E
C
S
N
K
K
V
S
I
D
Site 134
S1194
N
K
K
V
S
I
D
S
L
K
Q
R
L
N
V
Site 135
Y1209
A
V
K
E
K
S
Q
Y
E
Q
M
Y
Q
K
S
Site 136
Y1213
K
S
Q
Y
E
Q
M
Y
Q
K
S
K
E
E
L
Site 137
S1216
Y
E
Q
M
Y
Q
K
S
K
E
E
L
E
K
K
Site 138
T1228
E
K
K
D
L
K
L
T
L
L
V
S
R
I
S
Site 139
S1239
S
R
I
S
E
T
E
S
A
M
A
E
I
E
T
Site 140
S1249
A
E
I
E
T
A
A
S
K
Q
L
Q
E
L
A
Site 141
T1282
E
K
V
E
E
F
T
T
F
V
K
A
L
A
K
Site 142
T1317
K
N
R
D
A
C
K
T
S
T
H
K
A
Q
T
Site 143
T1324
T
S
T
H
K
A
Q
T
L
A
A
S
I
L
N
Site 144
S1335
S
I
L
N
I
S
R
S
D
L
E
E
I
L
D
Site 145
T1343
D
L
E
E
I
L
D
T
E
D
Q
V
E
I
E
Site 146
T1352
D
Q
V
E
I
E
K
T
K
I
D
A
E
N
D
Site 147
Y1365
N
D
K
E
W
M
L
Y
I
Q
K
L
L
E
G
Site 148
S1374
Q
K
L
L
E
G
Q
S
L
T
L
S
P
R
L
Site 149
T1376
L
L
E
G
Q
S
L
T
L
S
P
R
L
K
C
Site 150
S1378
E
G
Q
S
L
T
L
S
P
R
L
K
C
N
G
Site 151
S1398
Q
N
L
R
L
P
D
S
S
S
S
A
S
A
S
Site 152
S1399
N
L
R
L
P
D
S
S
S
S
A
S
A
S
_
Site 153
S1400
L
R
L
P
D
S
S
S
S
A
S
A
S
_
_
Site 154
S1401
R
L
P
D
S
S
S
S
A
S
A
S
_
_
_
Site 155
S1403
P
D
S
S
S
S
A
S
A
S
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation