KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
P4HTM
Full Name:
Transmembrane prolyl 4-hydroxylase
Alias:
Hypoxia-inducible factor prolyl hydroxylase 4
Type:
Mass (Da):
56661
Number AA:
502
UniProt ID:
Q9NXG6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
V
T
G
Q
R
P
E
T
A
A
A
E
E
A
S
Site 2
S85
L
L
L
F
V
H
Y
S
N
G
D
E
S
S
D
Site 3
S90
H
Y
S
N
G
D
E
S
S
D
P
G
P
Q
H
Site 4
S91
Y
S
N
G
D
E
S
S
D
P
G
P
Q
H
R
Site 5
T107
Q
G
P
G
P
E
P
T
L
G
P
L
T
R
L
Site 6
T129
E
R
K
V
Q
L
V
T
D
R
D
H
F
I
R
Site 7
T137
D
R
D
H
F
I
R
T
L
S
L
K
P
L
L
Site 8
Y179
Q
I
L
P
T
E
E
Y
E
E
A
M
S
T
M
Site 9
S184
E
E
Y
E
E
A
M
S
T
M
Q
V
S
Q
L
Site 10
T185
E
Y
E
E
A
M
S
T
M
Q
V
S
Q
L
D
Site 11
S245
P
D
G
D
G
V
L
S
L
Q
E
F
S
N
M
Site 12
Y260
D
L
R
D
F
H
K
Y
M
R
S
H
K
A
E
Site 13
S263
D
F
H
K
Y
M
R
S
H
K
A
E
S
S
E
Site 14
S268
M
R
S
H
K
A
E
S
S
E
L
V
R
N
S
Site 15
S269
R
S
H
K
A
E
S
S
E
L
V
R
N
S
H
Site 16
T278
L
V
R
N
S
H
H
T
W
L
Y
Q
G
E
G
Site 17
Y281
N
S
H
H
T
W
L
Y
Q
G
E
G
A
H
H
Site 18
T301
R
Q
R
V
L
R
L
T
R
L
S
P
E
I
V
Site 19
S311
S
P
E
I
V
E
L
S
E
P
L
Q
V
V
R
Site 20
Y319
E
P
L
Q
V
V
R
Y
G
E
G
G
H
Y
H
Site 21
Y325
R
Y
G
E
G
G
H
Y
H
A
H
V
D
S
G
Site 22
Y335
H
V
D
S
G
P
V
Y
P
E
T
I
C
S
H
Site 23
T338
S
G
P
V
Y
P
E
T
I
C
S
H
T
K
L
Site 24
S350
T
K
L
V
A
N
E
S
V
P
F
E
T
S
C
Site 25
S356
E
S
V
P
F
E
T
S
C
R
Y
M
T
V
L
Site 26
T375
N
V
T
G
G
G
E
T
V
F
P
V
A
D
N
Site 27
Y385
P
V
A
D
N
R
T
Y
D
E
M
S
L
I
Q
Site 28
S389
N
R
T
Y
D
E
M
S
L
I
Q
D
D
V
D
Site 29
T400
D
D
V
D
L
R
D
T
R
R
H
C
D
K
G
Site 30
Y422
Q
G
T
A
V
F
W
Y
N
Y
L
P
D
G
Q
Site 31
Y438
W
V
G
D
V
D
D
Y
S
L
H
G
G
C
L
Site 32
S485
A
R
E
G
G
T
D
S
Q
P
E
W
A
L
D
Site 33
Y495
E
W
A
L
D
R
A
Y
R
D
A
R
V
E
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation