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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRMT1
Full Name:
N(2),N(2)-dimethylguanosine tRNA methyltransferase
Alias:
Dimethyltransferase; FLJ20244; G26; Guanine-26,N; TRM1; TRM1 tRNA methyltransferase 1; TRNA 2,2-dimethylguanosine-26 methyltransferase; TRNA(guanine-26,N(2)-N(2)) methyltransferase; TRNA(m(2,2)G26)dimethyltransferase
Type:
Methyltransferase; EC 2.1.1.32
Mass (Da):
72234
Number AA:
659
UniProt ID:
Q9NXH9
International Prot ID:
IPI00020508
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0004809
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0008033
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
Q
G
S
S
L
W
L
S
L
T
Site 2
S5
_
_
_
M
Q
G
S
S
L
W
L
S
L
T
F
Site 3
S9
Q
G
S
S
L
W
L
S
L
T
F
R
S
A
R
Site 4
T11
S
S
L
W
L
S
L
T
F
R
S
A
R
V
L
Site 5
S19
F
R
S
A
R
V
L
S
R
A
R
F
F
E
W
Site 6
S28
A
R
F
F
E
W
Q
S
P
G
L
P
N
T
A
Site 7
T34
Q
S
P
G
L
P
N
T
A
A
M
E
N
G
T
Site 8
T55
R
P
R
E
V
Q
E
T
T
V
T
E
G
A
A
Site 9
T56
P
R
E
V
Q
E
T
T
V
T
E
G
A
A
K
Site 10
T58
E
V
Q
E
T
T
V
T
E
G
A
A
K
I
A
Site 11
Y74
P
S
A
N
E
V
F
Y
N
P
V
Q
E
F
N
Site 12
T85
Q
E
F
N
R
D
L
T
C
A
V
I
T
E
F
Site 13
S120
Q
K
V
V
V
D
L
S
E
Q
E
E
E
K
V
Site 14
S132
E
K
V
E
L
K
E
S
E
N
L
A
S
G
D
Site 15
T143
A
S
G
D
Q
P
R
T
A
A
V
G
E
I
C
Site 16
S179
L
E
V
P
G
L
R
S
V
V
A
N
D
A
S
Site 17
S186
S
V
V
A
N
D
A
S
T
R
A
V
D
L
I
Site 18
S209
V
A
H
L
V
Q
P
S
Q
A
D
A
R
M
L
Site 19
T240
D
P
Y
G
S
P
A
T
F
L
D
A
A
V
Q
Site 20
S275
N
S
G
E
T
C
Y
S
K
Y
G
A
M
A
L
Site 21
Y277
G
E
T
C
Y
S
K
Y
G
A
M
A
L
K
S
Site 22
S363
L
Q
R
L
G
K
A
S
G
V
P
S
G
R
A
Site 23
S367
G
K
A
S
G
V
P
S
G
R
A
K
F
S
A
Site 24
S373
P
S
G
R
A
K
F
S
A
A
C
G
P
P
V
Site 25
T381
A
A
C
G
P
P
V
T
P
E
C
E
H
C
G
Site 26
S416
G
R
V
L
E
A
V
S
A
N
P
G
R
F
H
Site 27
T424
A
N
P
G
R
F
H
T
S
E
R
I
R
G
V
Site 28
S425
N
P
G
R
F
H
T
S
E
R
I
R
G
V
L
Site 29
Y445
E
L
P
D
V
P
L
Y
Y
T
L
D
Q
L
S
Site 30
Y446
L
P
D
V
P
L
Y
Y
T
L
D
Q
L
S
S
Site 31
T447
P
D
V
P
L
Y
Y
T
L
D
Q
L
S
S
T
Site 32
S453
Y
T
L
D
Q
L
S
S
T
I
H
C
N
T
P
Site 33
T459
S
S
T
I
H
C
N
T
P
S
L
L
Q
L
R
Site 34
S461
T
I
H
C
N
T
P
S
L
L
Q
L
R
S
A
Site 35
S477
L
H
A
D
F
R
V
S
L
S
H
A
C
K
N
Site 36
S479
A
D
F
R
V
S
L
S
H
A
C
K
N
A
V
Site 37
T488
A
C
K
N
A
V
K
T
D
A
P
A
S
A
L
Site 38
S493
V
K
T
D
A
P
A
S
A
L
W
D
I
M
R
Site 39
S514
P
V
K
R
E
R
L
S
E
T
S
P
A
F
R
Site 40
S517
R
E
R
L
S
E
T
S
P
A
F
R
I
L
S
Site 41
S524
S
P
A
F
R
I
L
S
V
E
P
R
L
Q
A
Site 42
T534
P
R
L
Q
A
N
F
T
I
R
E
D
A
N
P
Site 43
S542
I
R
E
D
A
N
P
S
S
R
Q
R
G
L
K
Site 44
S543
R
E
D
A
N
P
S
S
R
Q
R
G
L
K
R
Site 45
T603
Q
R
A
A
R
L
K
T
F
P
C
K
R
F
K
Site 46
T613
C
K
R
F
K
E
G
T
C
Q
R
G
D
Q
C
Site 47
S623
R
G
D
Q
C
C
Y
S
H
S
P
P
T
P
R
Site 48
S625
D
Q
C
C
Y
S
H
S
P
P
T
P
R
V
S
Site 49
T628
C
Y
S
H
S
P
P
T
P
R
V
S
A
D
A
Site 50
S632
S
P
P
T
P
R
V
S
A
D
A
A
P
D
C
Site 51
T642
A
A
P
D
C
P
E
T
S
N
Q
T
P
P
G
Site 52
S643
A
P
D
C
P
E
T
S
N
Q
T
P
P
G
P
Site 53
T646
C
P
E
T
S
N
Q
T
P
P
G
P
G
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation