KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
BRE
Full Name:
BRCA1-A complex subunit BRE
Alias:
Brain and reproductive organ-expressed protein; BRCA1/BRCA2-containing complex subunit 45; BRCC4; BRCC45; NFRSF1A modulator
Type:
Apoptosis protein
Mass (Da):
43552
Number AA:
383
UniProt ID:
Q9NXR7
International Prot ID:
Isoform1 - IPI00149276
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0070531
GO:0070552
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0000268
GO:0031593
GO:0005164
PhosphoSite+
KinaseNET
Biological Process:
GO:0031572
GO:0006915
GO:0016568
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
P
E
V
A
L
N
R
Site 2
S15
N
R
I
S
P
M
L
S
P
F
I
S
S
V
V
Site 3
T32
G
K
V
G
L
D
A
T
N
C
L
R
I
T
D
Site 4
T38
A
T
N
C
L
R
I
T
D
L
K
S
G
C
T
Site 5
S42
L
R
I
T
D
L
K
S
G
C
T
S
L
T
P
Site 6
S46
D
L
K
S
G
C
T
S
L
T
P
G
P
N
C
Site 7
T48
K
S
G
C
T
S
L
T
P
G
P
N
C
D
R
Site 8
Y77
D
I
I
F
N
A
Q
Y
P
E
L
P
P
D
F
Site 9
S104
S
A
L
Q
N
L
A
S
W
N
P
S
N
P
E
Site 10
S108
N
L
A
S
W
N
P
S
N
P
E
C
L
L
L
Site 11
S130
Q
Y
H
Q
F
Q
C
S
R
L
R
E
S
S
R
Site 12
S135
Q
C
S
R
L
R
E
S
S
R
L
M
F
E
Y
Site 13
S136
C
S
R
L
R
E
S
S
R
L
M
F
E
Y
Q
Site 14
Y142
S
S
R
L
M
F
E
Y
Q
T
L
L
E
E
P
Site 15
T144
R
L
M
F
E
Y
Q
T
L
L
E
E
P
Q
Y
Site 16
Y151
T
L
L
E
E
P
Q
Y
G
E
N
M
E
I
Y
Site 17
Y158
Y
G
E
N
M
E
I
Y
A
G
K
K
N
N
W
Site 18
S170
N
N
W
T
G
E
F
S
A
R
F
L
L
K
L
Site 19
Y187
D
F
S
N
I
P
T
Y
L
L
K
D
V
N
E
Site 20
S204
G
E
D
V
A
L
L
S
V
S
F
E
D
T
E
Site 21
T210
L
S
V
S
F
E
D
T
E
A
T
Q
V
Y
P
Site 22
Y216
D
T
E
A
T
Q
V
Y
P
K
L
Y
L
S
P
Site 23
Y220
T
Q
V
Y
P
K
L
Y
L
S
P
R
I
E
H
Site 24
S222
V
Y
P
K
L
Y
L
S
P
R
I
E
H
A
L
Site 25
Y263
L
L
T
N
K
V
Q
Y
V
I
Q
G
Y
H
K
Site 26
Y268
V
Q
Y
V
I
Q
G
Y
H
K
R
R
E
Y
I
Site 27
Y274
G
Y
H
K
R
R
E
Y
I
A
A
F
L
S
H
Site 28
Y289
F
G
T
G
V
V
E
Y
D
A
E
G
F
T
K
Site 29
T324
F
F
P
R
D
Q
P
T
L
T
F
Q
S
V
Y
Site 30
T326
P
R
D
Q
P
T
L
T
F
Q
S
V
Y
H
F
Site 31
Y331
T
L
T
F
Q
S
V
Y
H
F
T
N
S
G
Q
Site 32
T334
F
Q
S
V
Y
H
F
T
N
S
G
Q
L
Y
S
Site 33
Y340
F
T
N
S
G
Q
L
Y
S
Q
A
Q
K
N
Y
Site 34
S341
T
N
S
G
Q
L
Y
S
Q
A
Q
K
N
Y
P
Site 35
Y347
Y
S
Q
A
Q
K
N
Y
P
Y
S
P
R
W
D
Site 36
S350
A
Q
K
N
Y
P
Y
S
P
R
W
D
G
N
E
Site 37
Y365
M
A
K
R
A
K
A
Y
F
K
T
F
V
P
Q
Site 38
T368
R
A
K
A
Y
F
K
T
F
V
P
Q
F
Q
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation