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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL28
Full Name:
Kelch-like protein 28
Alias:
BTB/POZ domain-containing protein 5
Type:
Mass (Da):
64192
Number AA:
571
UniProt ID:
Q9NXS3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
D
H
T
S
P
T
Y
M
L
A
N
L
T
H
Site 2
T14
T
Y
M
L
A
N
L
T
H
L
H
S
E
Q
L
Site 3
S18
A
N
L
T
H
L
H
S
E
Q
L
L
Q
G
L
Site 4
S69
A
M
F
T
G
N
L
S
E
K
E
N
S
E
V
Site 5
S74
N
L
S
E
K
E
N
S
E
V
E
F
Q
C
I
Site 6
T97
V
E
Y
A
Y
T
G
T
V
F
I
S
Q
D
T
Site 7
Y147
I
S
R
F
A
E
T
Y
G
C
R
D
L
Y
L
Site 8
Y200
A
T
E
E
T
V
F
Y
A
L
E
S
W
I
K
Site 9
Y208
A
L
E
S
W
I
K
Y
D
V
Q
E
R
Q
K
Site 10
Y216
D
V
Q
E
R
Q
K
Y
L
A
Q
L
L
N
S
Site 11
S223
Y
L
A
Q
L
L
N
S
V
R
L
P
L
L
S
Site 12
Y238
V
K
F
L
T
R
L
Y
E
A
N
H
L
I
R
Site 13
T249
H
L
I
R
D
D
R
T
C
K
H
L
L
N
E
Site 14
Y260
L
L
N
E
A
L
K
Y
H
F
M
P
E
H
R
Site 15
T272
E
H
R
L
S
H
Q
T
V
L
M
T
R
P
R
Site 16
Y304
C
L
D
S
V
E
M
Y
F
P
Q
N
D
S
W
Site 17
S368
P
D
T
N
T
W
T
S
L
E
R
M
N
E
S
Site 18
S375
S
L
E
R
M
N
E
S
R
S
T
L
G
V
V
Site 19
S377
E
R
M
N
E
S
R
S
T
L
G
V
V
V
L
Site 20
S398
L
G
G
Y
D
G
Q
S
Y
L
Q
S
V
E
K
Site 21
Y399
G
G
Y
D
G
Q
S
Y
L
Q
S
V
E
K
Y
Site 22
S402
D
G
Q
S
Y
L
Q
S
V
E
K
Y
I
P
K
Site 23
Y406
Y
L
Q
S
V
E
K
Y
I
P
K
I
R
K
W
Site 24
S448
Y
G
P
A
H
M
N
S
V
E
R
Y
D
P
S
Site 25
Y452
H
M
N
S
V
E
R
Y
D
P
S
K
D
S
W
Site 26
S455
S
V
E
R
Y
D
P
S
K
D
S
W
E
M
V
Site 27
S458
R
Y
D
P
S
K
D
S
W
E
M
V
A
S
M
Site 28
S491
V
G
G
H
N
G
V
S
H
L
S
S
I
E
R
Site 29
S495
N
G
V
S
H
L
S
S
I
E
R
Y
D
P
H
Site 30
Y499
H
L
S
S
I
E
R
Y
D
P
H
Q
N
Q
W
Site 31
S535
L
Y
V
V
G
G
H
S
G
S
S
Y
L
N
T
Site 32
S538
V
G
G
H
S
G
S
S
Y
L
N
T
V
Q
K
Site 33
Y539
G
G
H
S
G
S
S
Y
L
N
T
V
Q
K
Y
Site 34
T542
S
G
S
S
Y
L
N
T
V
Q
K
Y
D
P
I
Site 35
Y546
Y
L
N
T
V
Q
K
Y
D
P
I
S
D
T
W
Site 36
S550
V
Q
K
Y
D
P
I
S
D
T
W
L
D
S
A
Site 37
T552
K
Y
D
P
I
S
D
T
W
L
D
S
A
G
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation