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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NSMCE4A
Full Name:
Non-structural maintenance of chromosomes element 4 homolog A
Alias:
BA500G22.3; C10orf86; FLJ20003; Non-SMC element 4 A; NSE4A; PP4762
Type:
Mass (Da):
44301
Number AA:
385
UniProt ID:
Q9NXX6
International Prot ID:
IPI00014367
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
S
G
D
S
S
G
R
G
P
E
G
Site 2
S6
_
_
M
S
G
D
S
S
G
R
G
P
E
G
R
Site 3
T24
R
D
P
H
R
D
R
T
R
S
R
S
R
S
R
Site 4
S26
P
H
R
D
R
T
R
S
R
S
R
S
R
S
P
Site 5
S28
R
D
R
T
R
S
R
S
R
S
R
S
P
L
S
Site 6
S30
R
T
R
S
R
S
R
S
R
S
P
L
S
P
R
Site 7
S32
R
S
R
S
R
S
R
S
P
L
S
P
R
S
R
Site 8
S35
S
R
S
R
S
P
L
S
P
R
S
R
R
G
S
Site 9
S38
R
S
P
L
S
P
R
S
R
R
G
S
A
R
E
Site 10
S42
S
P
R
S
R
R
G
S
A
R
E
R
R
E
A
Site 11
S54
R
E
A
P
E
R
P
S
L
E
D
T
E
P
S
Site 12
T58
E
R
P
S
L
E
D
T
E
P
S
D
S
G
D
Site 13
S61
S
L
E
D
T
E
P
S
D
S
G
D
E
M
M
Site 14
S63
E
D
T
E
P
S
D
S
G
D
E
M
M
D
P
Site 15
S72
D
E
M
M
D
P
A
S
L
E
A
E
A
D
Q
Site 16
Y89
C
R
Q
I
R
H
Q
Y
R
A
L
I
N
S
V
Site 17
S95
Q
Y
R
A
L
I
N
S
V
Q
Q
N
R
E
D
Site 18
T111
L
N
A
G
D
K
L
T
E
V
L
E
E
A
N
Site 19
T119
E
V
L
E
E
A
N
T
L
F
N
E
V
S
R
Site 20
S125
N
T
L
F
N
E
V
S
R
A
R
E
A
V
L
Site 21
S153
E
K
A
K
Q
L
R
S
D
L
S
S
F
D
M
Site 22
S156
K
Q
L
R
S
D
L
S
S
F
D
M
L
R
Y
Site 23
S157
Q
L
R
S
D
L
S
S
F
D
M
L
R
Y
V
Site 24
Y163
S
S
F
D
M
L
R
Y
V
E
T
L
L
T
H
Site 25
S187
E
L
I
R
D
E
D
S
P
D
F
E
F
I
V
Site 26
Y195
P
D
F
E
F
I
V
Y
D
S
W
K
I
T
G
Site 27
T201
V
Y
D
S
W
K
I
T
G
R
T
A
E
N
T
Site 28
T208
T
G
R
T
A
E
N
T
F
N
K
T
H
T
F
Site 29
T214
N
T
F
N
K
T
H
T
F
H
F
L
L
G
S
Site 30
S258
Q
L
R
R
M
E
E
S
H
Q
E
A
T
E
K
Site 31
T276
R
I
L
G
L
L
Q
T
Y
F
R
E
D
P
D
Site 32
Y277
I
L
G
L
L
Q
T
Y
F
R
E
D
P
D
T
Site 33
T284
Y
F
R
E
D
P
D
T
P
M
S
F
F
D
F
Site 34
S287
E
D
P
D
T
P
M
S
F
F
D
F
V
V
D
Site 35
S297
D
F
V
V
D
P
H
S
F
P
R
T
V
E
N
Site 36
T301
D
P
H
S
F
P
R
T
V
E
N
I
F
H
V
Site 37
S333
L
P
V
I
E
P
V
S
I
N
E
E
N
E
G
Site 38
T345
N
E
G
F
E
H
N
T
Q
V
R
N
Q
G
I
Site 39
T366
D
W
E
E
I
V
K
T
F
E
I
S
E
P
V
Site 40
T375
E
I
S
E
P
V
I
T
P
S
Q
R
Q
Q
K
Site 41
S377
S
E
P
V
I
T
P
S
Q
R
Q
Q
K
P
S
Site 42
S384
S
Q
R
Q
Q
K
P
S
A
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation