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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX43
Full Name:
Probable ATP-dependent RNA helicase DDX43
Alias:
Cancer/testis antigen 13; CT13; DEAD (Asp-Glu-Ala-Asp) box polypeptide 43; DEAD box protein 43; DEAD box protein HAGE; DKFZp434H2114; EC 3.6.1.-; HAGE; Helical antigen
Type:
Helicase; RNA binding protein; EC 3.6.1.-
Mass (Da):
72844
Number AA:
648
UniProt ID:
Q9NXZ2
International Prot ID:
IPI00032899
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004004
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
H
G
G
A
P
K
A
S
T
W
V
V
A
S
R
Site 2
T12
G
G
A
P
K
A
S
T
W
V
V
A
S
R
R
Site 3
S17
A
S
T
W
V
V
A
S
R
R
S
S
T
V
S
Site 4
S20
W
V
V
A
S
R
R
S
S
T
V
S
R
A
P
Site 5
S21
V
V
A
S
R
R
S
S
T
V
S
R
A
P
E
Site 6
T22
V
A
S
R
R
S
S
T
V
S
R
A
P
E
R
Site 7
S24
S
R
R
S
S
T
V
S
R
A
P
E
R
R
P
Site 8
T38
P
A
E
E
L
N
R
T
G
P
E
G
Y
S
V
Site 9
S44
R
T
G
P
E
G
Y
S
V
G
R
G
G
R
W
Site 10
T54
R
G
G
R
W
R
G
T
S
R
P
P
E
A
V
Site 11
S55
G
G
R
W
R
G
T
S
R
P
P
E
A
V
A
Site 12
S88
A
V
I
G
R
G
G
S
K
I
K
N
I
Q
S
Site 13
S95
S
K
I
K
N
I
Q
S
T
T
N
T
T
I
Q
Site 14
T99
N
I
Q
S
T
T
N
T
T
I
Q
I
I
Q
E
Site 15
Y139
V
K
K
L
E
E
N
Y
N
S
E
C
G
I
D
Site 16
S141
K
L
E
E
N
Y
N
S
E
C
G
I
D
T
A
Site 17
S158
P
S
V
G
K
D
G
S
T
D
N
N
V
V
A
Site 18
T159
S
V
G
K
D
G
S
T
D
N
N
V
V
A
G
Site 19
T186
E
G
L
K
W
Q
K
T
K
W
A
D
L
P
P
Site 20
S202
K
K
N
F
Y
K
E
S
T
A
T
S
A
M
S
Site 21
T203
K
N
F
Y
K
E
S
T
A
T
S
A
M
S
K
Site 22
T205
F
Y
K
E
S
T
A
T
S
A
M
S
K
V
E
Site 23
S206
Y
K
E
S
T
A
T
S
A
M
S
K
V
E
A
Site 24
S209
S
T
A
T
S
A
M
S
K
V
E
A
D
S
W
Site 25
S215
M
S
K
V
E
A
D
S
W
R
K
E
N
F
N
Site 26
T242
P
I
P
N
P
T
C
T
F
D
D
A
F
Q
C
Site 27
Y250
F
D
D
A
F
Q
C
Y
P
E
V
M
E
N
I
Site 28
T266
K
A
G
F
Q
K
P
T
P
I
Q
S
Q
A
W
Site 29
S270
Q
K
P
T
P
I
Q
S
Q
A
W
P
I
V
L
Site 30
T293
A
Q
T
G
T
G
K
T
L
C
Y
L
M
P
G
Site 31
S309
I
H
L
V
L
Q
P
S
L
K
G
Q
R
N
R
Site 32
T323
R
P
G
M
L
V
L
T
P
T
R
E
L
A
L
Site 33
Y339
V
E
G
E
C
C
K
Y
S
Y
K
G
L
R
S
Site 34
S346
Y
S
Y
K
G
L
R
S
V
C
V
Y
G
G
G
Site 35
Y350
G
L
R
S
V
C
V
Y
G
G
G
N
R
D
E
Site 36
T372
G
V
D
I
I
I
A
T
P
G
R
L
N
D
L
Site 37
T423
D
V
R
P
D
R
Q
T
V
M
T
S
A
T
W
Site 38
T426
P
D
R
Q
T
V
M
T
S
A
T
W
P
H
S
Site 39
T429
Q
T
V
M
T
S
A
T
W
P
H
S
V
H
R
Site 40
S433
T
S
A
T
W
P
H
S
V
H
R
L
A
Q
S
Site 41
S440
S
V
H
R
L
A
Q
S
Y
L
K
E
P
M
I
Site 42
Y449
L
K
E
P
M
I
V
Y
V
G
T
L
D
L
V
Site 43
S459
T
L
D
L
V
A
V
S
S
V
K
Q
N
I
I
Site 44
S460
L
D
L
V
A
V
S
S
V
K
Q
N
I
I
V
Site 45
T479
E
K
W
S
H
M
Q
T
F
L
Q
S
M
S
S
Site 46
S483
H
M
Q
T
F
L
Q
S
M
S
S
T
D
K
V
Site 47
S516
L
G
N
I
S
V
E
S
L
H
G
D
R
E
Q
Site 48
T544
K
V
R
I
L
I
A
T
D
L
A
S
R
G
L
Site 49
Y560
V
H
D
V
T
H
V
Y
N
F
D
F
P
R
N
Site 50
Y571
F
P
R
N
I
E
E
Y
V
H
R
I
G
R
T
Site 51
T592
G
V
S
I
T
T
L
T
R
N
D
W
R
V
A
Site 52
S600
R
N
D
W
R
V
A
S
E
L
I
N
I
L
E
Site 53
S612
I
L
E
R
A
N
Q
S
I
P
E
E
L
V
S
Site 54
S619
S
I
P
E
E
L
V
S
M
A
E
R
F
K
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation