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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DPP3
Full Name:
Dipeptidyl peptidase 3
Alias:
Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidylpeptidase 3; Dipeptidylpeptidase III; Dipeptidyl-peptidase III; DPP III
Type:
Protease; EC 3.4.14.4
Mass (Da):
82589
Number AA:
737
UniProt ID:
Q9NY33
International Prot ID:
IPI00020672
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0008239
GO:0008237
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
P
N
D
I
G
V
S
S
L
D
C
R
E
A
F
Site 2
S27
R
E
A
F
R
L
L
S
P
T
E
R
L
Y
A
Site 3
T29
A
F
R
L
L
S
P
T
E
R
L
Y
A
Y
H
Site 4
Y33
L
S
P
T
E
R
L
Y
A
Y
H
L
S
R
A
Site 5
Y35
P
T
E
R
L
Y
A
Y
H
L
S
R
A
A
W
Site 6
S64
P
Y
I
Y
A
L
L
S
R
L
F
R
A
Q
D
Site 7
Y89
E
G
L
T
E
E
E
Y
Q
A
F
L
V
Y
A
Site 8
Y106
V
Y
S
N
M
G
N
Y
K
S
F
G
D
T
K
Site 9
S108
S
N
M
G
N
Y
K
S
F
G
D
T
K
F
V
Site 10
T112
N
Y
K
S
F
G
D
T
K
F
V
P
N
L
P
Site 11
S130
L
E
R
V
I
L
G
S
E
A
A
Q
Q
H
P
Site 12
S153
T
C
G
E
L
M
F
S
L
E
P
R
L
R
H
Site 13
T169
G
L
G
K
E
G
I
T
T
Y
F
S
G
N
C
Site 14
T170
L
G
K
E
G
I
T
T
Y
F
S
G
N
C
T
Site 15
Y171
G
K
E
G
I
T
T
Y
F
S
G
N
C
T
M
Site 16
T177
T
Y
F
S
G
N
C
T
M
E
D
A
K
L
A
Site 17
S190
L
A
Q
D
F
L
D
S
Q
N
L
S
A
Y
N
Site 18
S194
F
L
D
S
Q
N
L
S
A
Y
N
T
R
L
F
Site 19
T198
Q
N
L
S
A
Y
N
T
R
L
F
K
E
V
D
Site 20
Y211
V
D
G
E
G
K
P
Y
Y
E
V
R
L
A
S
Site 21
Y212
D
G
E
G
K
P
Y
Y
E
V
R
L
A
S
V
Site 22
S218
Y
Y
E
V
R
L
A
S
V
L
G
S
E
P
S
Site 23
S222
R
L
A
S
V
L
G
S
E
P
S
L
D
S
E
Site 24
S225
S
V
L
G
S
E
P
S
L
D
S
E
V
T
S
Site 25
S228
G
S
E
P
S
L
D
S
E
V
T
S
K
L
K
Site 26
S232
S
L
D
S
E
V
T
S
K
L
K
S
Y
E
F
Site 27
S236
E
V
T
S
K
L
K
S
Y
E
F
R
G
S
P
Site 28
Y237
V
T
S
K
L
K
S
Y
E
F
R
G
S
P
F
Site 29
S242
K
S
Y
E
F
R
G
S
P
F
Q
V
T
R
G
Site 30
Y251
F
Q
V
T
R
G
D
Y
A
P
I
L
Q
K
V
Site 31
Y281
Q
G
Q
M
L
A
Q
Y
I
E
S
F
T
Q
G
Site 32
S284
M
L
A
Q
Y
I
E
S
F
T
Q
G
S
I
E
Site 33
T286
A
Q
Y
I
E
S
F
T
Q
G
S
I
E
A
H
Site 34
S289
I
E
S
F
T
Q
G
S
I
E
A
H
K
R
G
Site 35
S297
I
E
A
H
K
R
G
S
R
F
W
I
Q
D
K
Site 36
S310
D
K
G
P
I
V
E
S
Y
I
G
F
I
E
S
Site 37
S317
S
Y
I
G
F
I
E
S
Y
R
D
P
F
G
S
Site 38
Y318
Y
I
G
F
I
E
S
Y
R
D
P
F
G
S
R
Site 39
S324
S
Y
R
D
P
F
G
S
R
G
E
F
E
G
F
Site 40
S349
K
F
E
R
L
V
A
S
A
E
Q
L
L
K
E
Site 41
T362
K
E
L
P
W
P
P
T
F
E
K
D
K
F
L
Site 42
T370
F
E
K
D
K
F
L
T
P
D
F
T
S
L
D
Site 43
Y395
A
G
I
N
I
P
N
Y
D
D
L
R
Q
T
E
Site 44
T401
N
Y
D
D
L
R
Q
T
E
G
F
K
N
V
S
Site 45
T425
A
T
Q
R
E
K
L
T
F
L
E
E
D
D
K
Site 46
Y435
E
E
D
D
K
D
L
Y
I
L
W
K
G
P
S
Site 47
S457
H
E
L
L
G
H
G
S
G
K
L
F
V
Q
D
Site 48
T475
A
F
N
F
D
Q
E
T
V
I
N
P
E
T
G
Site 49
T481
E
T
V
I
N
P
E
T
G
E
Q
I
Q
S
W
Site 50
S487
E
T
G
E
Q
I
Q
S
W
Y
R
S
G
E
T
Site 51
Y489
G
E
Q
I
Q
S
W
Y
R
S
G
E
T
W
D
Site 52
S497
R
S
G
E
T
W
D
S
K
F
S
T
I
A
S
Site 53
S500
E
T
W
D
S
K
F
S
T
I
A
S
S
Y
E
Site 54
T501
T
W
D
S
K
F
S
T
I
A
S
S
Y
E
E
Site 55
S504
S
K
F
S
T
I
A
S
S
Y
E
E
C
R
A
Site 56
S505
K
F
S
T
I
A
S
S
Y
E
E
C
R
A
E
Site 57
T588
E
A
G
E
G
L
V
T
I
T
P
T
T
G
S
Site 58
T590
G
E
G
L
V
T
I
T
P
T
T
G
S
D
G
Site 59
S608
A
R
V
R
L
D
R
S
K
I
R
S
V
G
K
Site 60
S612
L
D
R
S
K
I
R
S
V
G
K
P
A
L
E
Site 61
S630
R
R
L
Q
V
L
K
S
T
G
D
V
A
G
G
Site 62
T631
R
L
Q
V
L
K
S
T
G
D
V
A
G
G
R
Site 63
T646
A
L
Y
E
G
Y
A
T
V
T
D
A
P
P
E
Site 64
T648
Y
E
G
Y
A
T
V
T
D
A
P
P
E
C
F
Site 65
S668
T
V
L
L
R
K
E
S
R
K
L
I
V
Q
P
Site 66
S682
P
N
T
R
L
E
G
S
D
V
Q
L
L
E
Y
Site 67
S699
S
A
A
G
L
I
R
S
F
S
E
R
F
P
E
Site 68
S701
A
G
L
I
R
S
F
S
E
R
F
P
E
D
G
Site 69
S730
A
R
F
W
K
G
P
S
E
A
P
S
G
Q
A
Site 70
S734
K
G
P
S
E
A
P
S
G
Q
A
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation