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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPHK1
Full Name:
Sphingosine kinase 1
Alias:
EC 2.7.1.-; EC 2.7.1.91; SK1; SPHK; SPK; SPK1
Type:
Kinase, lipid, Lipid Metabolism group, Sphingolipid metabolism family
Mass (Da):
42518
Number AA:
384
UniProt ID:
Q9NYA1
International Prot ID:
IPI00182048
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005624
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0017050
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0007205
GO:0006916
GO:0019722
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T50
A
E
A
E
I
S
F
T
L
M
L
T
E
R
R
Site 2
T54
I
S
F
T
L
M
L
T
E
R
R
N
H
A
R
Site 3
S66
H
A
R
E
L
V
R
S
E
E
L
G
R
W
D
Site 4
T99
M
E
R
P
D
W
E
T
A
I
Q
K
P
L
C
Site 5
S107
A
I
Q
K
P
L
C
S
L
P
A
G
S
G
N
Site 6
S119
S
G
N
A
L
A
A
S
L
N
H
Y
A
G
Y
Site 7
Y123
L
A
A
S
L
N
H
Y
A
G
Y
E
Q
V
T
Site 8
Y126
S
L
N
H
Y
A
G
Y
E
Q
V
T
N
E
D
Site 9
S181
I
A
D
V
D
L
E
S
E
K
Y
R
R
L
G
Site 10
Y184
V
D
L
E
S
E
K
Y
R
R
L
G
E
M
R
Site 11
T193
R
L
G
E
M
R
F
T
L
G
T
F
L
R
L
Site 12
T205
L
R
L
A
A
L
R
T
Y
R
G
R
L
A
Y
Site 13
Y206
R
L
A
A
L
R
T
Y
R
G
R
L
A
Y
L
Site 14
Y212
T
Y
R
G
R
L
A
Y
L
P
V
G
R
V
G
Site 15
S220
L
P
V
G
R
V
G
S
K
T
P
A
S
P
V
Site 16
S225
V
G
S
K
T
P
A
S
P
V
V
V
Q
Q
G
Site 17
S247
P
L
E
E
P
V
P
S
H
W
T
V
V
P
D
Site 18
T250
E
P
V
P
S
H
W
T
V
V
P
D
E
D
F
Site 19
Y314
E
K
G
R
H
M
E
Y
E
C
P
Y
L
V
Y
Site 20
Y321
Y
E
C
P
Y
L
V
Y
V
P
V
V
A
F
R
Site 21
S371
G
C
V
E
P
P
P
S
W
K
P
Q
Q
M
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation