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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSD3
Full Name:
PH and SEC7 domain-containing protein 3
Alias:
ADP-ribosylation factor guanine nucleotide factor 6; DKFZp761K1423; EFA6R; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6;Hepatocellular carcinoma-associated antigen 6; HCA67; Hepatocellular carcinoma-associated antigen 67; KIAA0942; Pleckstrin and Sec7 domain containing 3; Pleckstrin and sec7 domain containing protein 3
Type:
Guanine nucleotide exchange factor, ARF
Mass (Da):
116034
Number AA:
1048
UniProt ID:
Q9NYI0
International Prot ID:
IPI00178366
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0014069
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0005086
PhosphoSite+
KinaseNET
Biological Process:
GO:0032012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
G
R
S
A
A
A
E
T
F
V
W
V
N
N
A
Site 2
Y29
Q
S
V
A
K
A
K
Y
E
F
L
F
G
R
S
Site 3
T43
S
E
G
K
A
P
D
T
S
D
H
G
G
S
T
Site 4
S44
E
G
K
A
P
D
T
S
D
H
G
G
S
T
L
Site 5
T50
T
S
D
H
G
G
S
T
L
L
P
P
N
V
T
Site 6
Y63
V
T
N
E
F
P
E
Y
G
T
M
E
E
G
G
Site 7
S76
G
G
E
G
L
R
A
S
L
E
F
D
G
E
A
Site 8
T98
Q
Q
G
V
Q
P
L
T
G
C
H
S
G
L
D
Site 9
S102
Q
P
L
T
G
C
H
S
G
L
D
S
V
T
E
Site 10
S106
G
C
H
S
G
L
D
S
V
T
E
G
P
K
D
Site 11
T108
H
S
G
L
D
S
V
T
E
G
P
K
D
V
R
Site 12
S119
K
D
V
R
E
A
P
S
Q
S
H
L
K
E
Q
Site 13
S127
Q
S
H
L
K
E
Q
S
L
Q
P
I
D
S
L
Site 14
S147
A
T
E
A
R
I
I
S
G
T
L
Q
A
T
K
Site 15
S163
L
D
Q
D
A
V
S
S
F
S
V
Q
Q
V
E
Site 16
T175
Q
V
E
K
E
L
D
T
A
S
R
K
T
Q
R
Site 17
S177
E
K
E
L
D
T
A
S
R
K
T
Q
R
V
N
Site 18
T180
L
D
T
A
S
R
K
T
Q
R
V
N
K
T
L
Site 19
T186
K
T
Q
R
V
N
K
T
L
P
A
G
Q
K
N
Site 20
S200
N
L
P
E
I
P
L
S
A
E
V
T
T
E
E
Site 21
S208
A
E
V
T
T
E
E
S
F
Y
L
S
I
Q
K
Site 22
Y210
V
T
T
E
E
S
F
Y
L
S
I
Q
K
D
L
Site 23
S212
T
E
E
S
F
Y
L
S
I
Q
K
D
L
T
A
Site 24
S230
G
D
T
Q
A
E
I
S
Q
I
M
N
N
G
R
Site 25
S274
G
F
L
K
E
Q
R
S
A
L
G
R
E
H
P
Site 26
S287
H
P
G
G
C
D
R
S
S
S
M
G
R
P
G
Site 27
S288
P
G
G
C
D
R
S
S
S
M
G
R
P
G
R
Site 28
S289
G
G
C
D
R
S
S
S
M
G
R
P
G
R
V
Site 29
T309
Q
G
V
E
I
L
W
T
G
G
D
K
R
E
T
Site 30
T316
T
G
G
D
K
R
E
T
Q
H
P
I
D
F
E
Site 31
S325
H
P
I
D
F
E
T
S
L
Q
R
T
A
S
P
Site 32
T329
F
E
T
S
L
Q
R
T
A
S
P
D
S
K
E
Site 33
S331
T
S
L
Q
R
T
A
S
P
D
S
K
E
S
S
Site 34
S334
Q
R
T
A
S
P
D
S
K
E
S
S
K
V
P
Site 35
S338
S
P
D
S
K
E
S
S
K
V
P
R
H
L
I
Site 36
S346
K
V
P
R
H
L
I
S
S
A
G
L
C
N
S
Site 37
S353
S
S
A
G
L
C
N
S
S
S
L
T
E
N
V
Site 38
S355
A
G
L
C
N
S
S
S
L
T
E
N
V
W
D
Site 39
T357
L
C
N
S
S
S
L
T
E
N
V
W
D
E
S
Site 40
S364
T
E
N
V
W
D
E
S
W
K
A
P
S
E
R
Site 41
S369
D
E
S
W
K
A
P
S
E
R
P
G
T
S
S
Site 42
T374
A
P
S
E
R
P
G
T
S
S
G
T
F
S
P
Site 43
S375
P
S
E
R
P
G
T
S
S
G
T
F
S
P
V
Site 44
S376
S
E
R
P
G
T
S
S
G
T
F
S
P
V
R
Site 45
T378
R
P
G
T
S
S
G
T
F
S
P
V
R
L
D
Site 46
S380
G
T
S
S
G
T
F
S
P
V
R
L
D
E
S
Site 47
S387
S
P
V
R
L
D
E
S
G
E
D
E
V
F
L
Site 48
T404
N
K
Q
H
L
E
K
T
P
K
P
E
R
D
R
Site 49
S415
E
R
D
R
E
R
I
S
E
Q
E
E
H
V
K
Site 50
Y433
E
D
I
L
G
P
G
Y
T
E
D
S
T
D
V
Site 51
S437
G
P
G
Y
T
E
D
S
T
D
V
Y
S
S
Q
Site 52
T438
P
G
Y
T
E
D
S
T
D
V
Y
S
S
Q
F
Site 53
Y441
T
E
D
S
T
D
V
Y
S
S
Q
F
E
T
I
Site 54
S443
D
S
T
D
V
Y
S
S
Q
F
E
T
I
L
D
Site 55
T447
V
Y
S
S
Q
F
E
T
I
L
D
N
T
S
L
Site 56
S453
E
T
I
L
D
N
T
S
L
Y
Y
S
A
E
S
Site 57
Y455
I
L
D
N
T
S
L
Y
Y
S
A
E
S
L
E
Site 58
S457
D
N
T
S
L
Y
Y
S
A
E
S
L
E
T
L
Site 59
S460
S
L
Y
Y
S
A
E
S
L
E
T
L
Y
S
E
Site 60
T463
Y
S
A
E
S
L
E
T
L
Y
S
E
P
D
S
Site 61
Y465
A
E
S
L
E
T
L
Y
S
E
P
D
S
Y
F
Site 62
S466
E
S
L
E
T
L
Y
S
E
P
D
S
Y
F
S
Site 63
S470
T
L
Y
S
E
P
D
S
Y
F
S
F
E
M
P
Site 64
Y471
L
Y
S
E
P
D
S
Y
F
S
F
E
M
P
L
Site 65
S473
S
E
P
D
S
Y
F
S
F
E
M
P
L
T
P
Site 66
S497
G
Q
F
L
E
R
T
S
G
G
G
H
Q
D
I
Site 67
S506
G
G
H
Q
D
I
L
S
V
S
A
D
G
G
I
Site 68
S531
G
L
N
D
A
S
D
S
I
Y
T
K
G
T
P
Site 69
Y533
N
D
A
S
D
S
I
Y
T
K
G
T
P
E
I
Site 70
T537
D
S
I
Y
T
K
G
T
P
E
I
A
F
W
G
Site 71
T551
G
S
N
A
G
V
K
T
T
R
L
E
A
H
S
Site 72
T552
S
N
A
G
V
K
T
T
R
L
E
A
H
S
E
Site 73
S558
T
T
R
L
E
A
H
S
E
M
G
S
T
E
I
Site 74
S562
E
A
H
S
E
M
G
S
T
E
I
L
E
K
E
Site 75
T570
T
E
I
L
E
K
E
T
P
E
N
L
S
N
G
Site 76
S575
K
E
T
P
E
N
L
S
N
G
T
S
S
N
V
Site 77
S579
E
N
L
S
N
G
T
S
S
N
V
E
A
A
K
Site 78
Y593
K
R
L
A
K
R
L
Y
Q
L
D
R
F
K
R
Site 79
Y621
S
K
L
V
A
E
E
Y
L
K
F
F
D
F
T
Site 80
T631
F
F
D
F
T
G
M
T
L
D
Q
S
L
R
Y
Site 81
S635
T
G
M
T
L
D
Q
S
L
R
Y
F
F
K
A
Site 82
S644
R
Y
F
F
K
A
F
S
L
V
G
E
T
Q
E
Site 83
Y663
L
I
H
F
S
N
R
Y
F
Y
C
N
P
D
T
Site 84
Y665
H
F
S
N
R
Y
F
Y
C
N
P
D
T
I
A
Site 85
Y728
K
D
L
L
K
A
L
Y
N
S
I
K
N
E
K
Site 86
S748
D
D
E
E
K
K
K
S
P
S
E
S
T
E
E
Site 87
S750
E
E
K
K
K
S
P
S
E
S
T
E
E
K
A
Site 88
S752
K
K
K
S
P
S
E
S
T
E
E
K
A
N
G
Site 89
T764
A
N
G
T
H
P
K
T
I
S
R
I
G
S
T
Site 90
S766
G
T
H
P
K
T
I
S
R
I
G
S
T
T
N
Site 91
S770
K
T
I
S
R
I
G
S
T
T
N
P
F
L
D
Site 92
T771
T
I
S
R
I
G
S
T
T
N
P
F
L
D
I
Site 93
T772
I
S
R
I
G
S
T
T
N
P
F
L
D
I
P
Site 94
Y787
H
D
P
N
A
A
V
Y
K
S
G
F
L
A
R
Site 95
T805
A
D
M
D
G
K
K
T
P
R
G
K
R
G
W
Site 96
T814
R
G
K
R
G
W
K
T
F
Y
A
V
L
K
G
Site 97
Y816
K
R
G
W
K
T
F
Y
A
V
L
K
G
T
V
Site 98
Y825
V
L
K
G
T
V
L
Y
L
Q
K
D
E
Y
K
Site 99
Y831
L
Y
L
Q
K
D
E
Y
K
P
E
K
A
L
S
Site 100
S838
Y
K
P
E
K
A
L
S
E
E
D
L
K
N
A
Site 101
S847
E
D
L
K
N
A
V
S
V
H
H
A
L
A
S
Site 102
Y859
L
A
S
K
A
T
D
Y
E
K
K
P
N
V
F
Site 103
T880
W
R
V
L
L
F
Q
T
Q
S
P
E
E
M
Q
Site 104
S882
V
L
L
F
Q
T
Q
S
P
E
E
M
Q
G
W
Site 105
S911
P
F
P
A
A
I
G
S
Q
K
K
F
S
R
P
Site 106
S916
I
G
S
Q
K
K
F
S
R
P
L
L
P
A
T
Site 107
T923
S
R
P
L
L
P
A
T
T
T
K
L
S
Q
E
Site 108
T924
R
P
L
L
P
A
T
T
T
K
L
S
Q
E
E
Site 109
T925
P
L
L
P
A
T
T
T
K
L
S
Q
E
E
Q
Site 110
S928
P
A
T
T
T
K
L
S
Q
E
E
Q
L
K
S
Site 111
S935
S
Q
E
E
Q
L
K
S
H
E
S
K
L
K
Q
Site 112
T945
S
K
L
K
Q
I
T
T
E
L
A
E
H
R
S
Site 113
S952
T
E
L
A
E
H
R
S
Y
P
P
D
K
K
V
Site 114
Y953
E
L
A
E
H
R
S
Y
P
P
D
K
K
V
K
Site 115
Y967
K
A
K
D
V
D
E
Y
K
L
K
D
H
Y
L
Site 116
Y973
E
Y
K
L
K
D
H
Y
L
E
F
E
K
T
R
Site 117
T979
H
Y
L
E
F
E
K
T
R
Y
E
M
Y
V
S
Site 118
Y981
L
E
F
E
K
T
R
Y
E
M
Y
V
S
I
L
Site 119
Y984
E
K
T
R
Y
E
M
Y
V
S
I
L
K
E
G
Site 120
S986
T
R
Y
E
M
Y
V
S
I
L
K
E
G
G
K
Site 121
S997
E
G
G
K
E
L
L
S
N
D
E
S
E
A
A
Site 122
S1001
E
L
L
S
N
D
E
S
E
A
A
G
L
K
K
Site 123
S1009
E
A
A
G
L
K
K
S
H
S
S
P
S
L
N
Site 124
S1011
A
G
L
K
K
S
H
S
S
P
S
L
N
P
D
Site 125
S1012
G
L
K
K
S
H
S
S
P
S
L
N
P
D
T
Site 126
S1014
K
K
S
H
S
S
P
S
L
N
P
D
T
S
P
Site 127
T1019
S
P
S
L
N
P
D
T
S
P
I
T
A
K
V
Site 128
S1020
P
S
L
N
P
D
T
S
P
I
T
A
K
V
K
Site 129
T1023
N
P
D
T
S
P
I
T
A
K
V
K
R
N
V
Site 130
S1031
A
K
V
K
R
N
V
S
E
R
K
D
H
R
P
Site 131
T1040
R
K
D
H
R
P
E
T
P
S
I
K
Q
K
V
Site 132
S1042
D
H
R
P
E
T
P
S
I
K
Q
K
V
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation