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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DONSON
Full Name:
Protein downstream neighbor of Son
Alias:
B17; C21orf60; C2TA; DKFZP434M035; DONS; downstream neighbor of Son
Type:
Mass (Da):
62750
Number AA:
UniProt ID:
Q9NYP3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
A
L
S
V
P
G
Y
S
P
G
F
R
K
P
Site 2
S9
A
L
S
V
P
G
Y
S
P
G
F
R
K
P
P
Site 3
S28
L
R
R
K
R
A
R
S
R
G
A
A
A
S
P
Site 4
S34
R
S
R
G
A
A
A
S
P
P
R
E
L
T
E
Site 5
T40
A
S
P
P
R
E
L
T
E
P
A
A
R
R
A
Site 6
S68
A
G
G
R
G
G
G
S
G
G
G
P
A
A
A
Site 7
S111
A
P
V
P
F
L
D
S
N
Q
E
N
D
L
L
Site 8
T128
E
K
F
P
E
R
T
T
V
T
E
L
P
Q
T
Site 9
T130
F
P
E
R
T
T
V
T
E
L
P
Q
T
S
H
Site 10
T135
T
V
T
E
L
P
Q
T
S
H
V
S
F
S
E
Site 11
S136
V
T
E
L
P
Q
T
S
H
V
S
F
S
E
P
Site 12
S139
L
P
Q
T
S
H
V
S
F
S
E
P
D
I
P
Site 13
S141
Q
T
S
H
V
S
F
S
E
P
D
I
P
S
S
Site 14
S147
F
S
E
P
D
I
P
S
S
K
S
T
E
L
P
Site 15
S148
S
E
P
D
I
P
S
S
K
S
T
E
L
P
V
Site 16
S150
P
D
I
P
S
S
K
S
T
E
L
P
V
D
W
Site 17
T151
D
I
P
S
S
K
S
T
E
L
P
V
D
W
S
Site 18
T161
P
V
D
W
S
I
K
T
R
L
L
F
T
S
S
Site 19
S167
K
T
R
L
L
F
T
S
S
Q
P
F
T
W
A
Site 20
S168
T
R
L
L
F
T
S
S
Q
P
F
T
W
A
D
Site 21
T172
F
T
S
S
Q
P
F
T
W
A
D
H
L
K
A
Site 22
T193
L
V
Q
H
C
R
A
T
E
V
T
L
P
K
S
Site 23
T196
H
C
R
A
T
E
V
T
L
P
K
S
I
Q
D
Site 24
S200
T
E
V
T
L
P
K
S
I
Q
D
P
K
L
S
Site 25
T213
L
S
S
E
L
R
C
T
F
Q
Q
S
L
I
Y
Site 26
S246
R
K
M
A
G
K
T
S
P
W
S
N
D
A
T
Site 27
S249
A
G
K
T
S
P
W
S
N
D
A
T
L
Q
H
Site 28
T253
S
P
W
S
N
D
A
T
L
Q
H
V
L
M
S
Site 29
T267
S
D
W
S
V
S
F
T
S
L
Y
N
L
L
K
Site 30
S268
D
W
S
V
S
F
T
S
L
Y
N
L
L
K
T
Site 31
S326
R
N
E
G
I
E
F
S
L
P
L
I
K
E
S
Site 32
T339
E
S
G
H
K
K
E
T
A
S
G
T
S
L
G
Site 33
S341
G
H
K
K
E
T
A
S
G
T
S
L
G
Y
G
Site 34
S354
Y
G
E
E
Q
A
I
S
D
E
D
E
E
E
S
Site 35
S361
S
D
E
D
E
E
E
S
F
S
W
L
E
E
M
Site 36
S363
E
D
E
E
E
S
F
S
W
L
E
E
M
G
V
Site 37
S381
I
K
K
P
D
I
L
S
I
K
L
R
K
E
K
Site 38
S399
Q
M
D
H
R
P
E
S
V
V
L
V
K
G
I
Site 39
S420
N
F
L
I
N
S
K
S
L
V
A
T
S
G
P
Site 40
T424
N
S
K
S
L
V
A
T
S
G
P
Q
A
G
L
Site 41
S453
M
Q
M
L
K
A
R
S
V
N
V
K
T
Q
A
Site 42
T458
A
R
S
V
N
V
K
T
Q
A
L
S
G
Y
R
Site 43
S469
S
G
Y
R
D
Q
F
S
L
E
I
T
G
P
I
Site 44
T473
D
Q
F
S
L
E
I
T
G
P
I
M
P
H
S
Site 45
T485
P
H
S
L
H
S
L
T
M
L
L
K
S
S
Q
Site 46
S490
S
L
T
M
L
L
K
S
S
Q
S
G
S
F
S
Site 47
S495
L
K
S
S
Q
S
G
S
F
S
A
V
L
Y
P
Site 48
S497
S
S
Q
S
G
S
F
S
A
V
L
Y
P
H
E
Site 49
T529
E
V
V
H
K
E
L
T
N
C
G
L
H
P
N
Site 50
T537
N
C
G
L
H
P
N
T
L
E
Q
L
S
Q
I
Site 51
S542
P
N
T
L
E
Q
L
S
Q
I
P
L
L
G
K
Site 52
Y560
R
N
V
V
L
R
D
Y
I
Y
N
W
R
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation