KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SIGLEC8
Full Name:
Sialic acid-binding Ig-like lectin 8
Alias:
SAF2
Type:
Membrane protein
Mass (Da):
54042
Number AA:
499
UniProt ID:
Q9NYZ4
International Prot ID:
IPI00171647
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005529
GO:0004888
PhosphoSite+
KinaseNET
Biological Process:
GO:0007155
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S134
E
R
G
S
M
K
W
S
Y
K
S
Q
L
N
Y
Site 2
Y135
R
G
S
M
K
W
S
Y
K
S
Q
L
N
Y
K
Site 3
Y141
S
Y
K
S
Q
L
N
Y
K
T
K
Q
L
S
V
Site 4
S391
V
R
S
C
R
K
K
S
A
R
P
A
A
G
V
Site 5
S412
D
A
K
A
I
R
G
S
A
S
Q
G
P
L
T
Site 6
S414
K
A
I
R
G
S
A
S
Q
G
P
L
T
E
S
Site 7
T419
S
A
S
Q
G
P
L
T
E
S
W
K
D
G
N
Site 8
S421
S
Q
G
P
L
T
E
S
W
K
D
G
N
P
L
Site 9
S439
P
P
A
V
A
P
S
S
G
E
E
G
E
L
H
Site 10
Y447
G
E
E
G
E
L
H
Y
A
T
L
S
F
H
K
Site 11
T449
E
G
E
L
H
Y
A
T
L
S
F
H
K
V
K
Site 12
S451
E
L
H
Y
A
T
L
S
F
H
K
V
K
P
Q
Site 13
S468
Q
G
Q
E
A
T
D
S
E
Y
S
E
I
K
I
Site 14
Y470
Q
E
A
T
D
S
E
Y
S
E
I
K
I
H
K
Site 15
T480
I
K
I
H
K
R
E
T
A
E
T
Q
A
C
L
Site 16
T483
H
K
R
E
T
A
E
T
Q
A
C
L
R
N
H
Site 17
S493
C
L
R
N
H
N
P
S
S
K
E
V
R
G
_
Site 18
S494
L
R
N
H
N
P
S
S
K
E
V
R
G
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation