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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ERAP1
Full Name:
Endoplasmic reticulum aminopeptidase 1
Alias:
A- LAP; Adipocyte-derived leucine aminopeptidase precursor; Aminopeptidase PILS; APPILS; ARTS-1; EC 3.4.11.-; PILS-AP; Puromycin-insensitive leucyl- specific aminopeptidase; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
Type:
Protease
Mass (Da):
107235
Number AA:
941
UniProt ID:
Q9NZ08
International Prot ID:
IPI00165949
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005788
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0005151
GO:0005138
PhosphoSite+
KinaseNET
Biological Process:
GO:0001525
GO:0019885
GO:0045444
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
L
L
T
V
S
T
P
S
W
C
Q
S
T
E
A
Site 2
S34
S
T
P
S
W
C
Q
S
T
E
A
S
P
K
R
Site 3
S38
W
C
Q
S
T
E
A
S
P
K
R
S
D
G
T
Site 4
S42
T
E
A
S
P
K
R
S
D
G
T
P
F
P
W
Site 5
T45
S
P
K
R
S
D
G
T
P
F
P
W
N
K
I
Site 6
Y57
N
K
I
R
L
P
E
Y
V
I
P
V
H
Y
D
Site 7
S97
T
S
T
I
I
L
H
S
H
H
L
Q
I
S
R
Site 8
S103
H
S
H
H
L
Q
I
S
R
A
T
L
R
K
G
Site 9
T106
H
L
Q
I
S
R
A
T
L
R
K
G
A
G
E
Site 10
S116
K
G
A
G
E
R
L
S
E
E
P
L
Q
V
L
Site 11
T158
Y
A
G
N
L
S
E
T
F
H
G
F
Y
K
S
Site 12
Y167
H
G
F
Y
K
S
T
Y
R
T
K
E
G
E
L
Site 13
T169
F
Y
K
S
T
Y
R
T
K
E
G
E
L
R
I
Site 14
S179
G
E
L
R
I
L
A
S
T
Q
F
E
P
T
A
Site 15
T185
A
S
T
Q
F
E
P
T
A
A
R
M
A
F
P
Site 16
S202
D
E
P
A
F
K
A
S
F
S
I
K
I
R
R
Site 17
S217
E
P
R
H
L
A
I
S
N
M
P
L
V
K
S
Site 18
T239
I
E
D
H
F
D
V
T
V
K
M
S
T
Y
L
Site 19
S268
T
K
S
G
V
K
V
S
V
Y
A
V
P
D
K
Site 20
Y270
S
G
V
K
V
S
V
Y
A
V
P
D
K
I
N
Site 21
Y281
D
K
I
N
Q
A
D
Y
A
L
D
A
A
V
T
Site 22
S298
E
F
Y
E
D
Y
F
S
I
P
Y
P
L
P
K
Site 23
Y301
E
D
Y
F
S
I
P
Y
P
L
P
K
Q
D
L
Site 24
T325
A
M
E
N
W
G
L
T
T
Y
R
E
S
A
L
Site 25
T326
M
E
N
W
G
L
T
T
Y
R
E
S
A
L
L
Site 26
Y327
E
N
W
G
L
T
T
Y
R
E
S
A
L
L
F
Site 27
S330
G
L
T
T
Y
R
E
S
A
L
L
F
D
A
E
Site 28
S339
L
L
F
D
A
E
K
S
S
A
S
S
K
L
G
Site 29
S340
L
F
D
A
E
K
S
S
A
S
S
K
L
G
I
Site 30
S343
A
E
K
S
S
A
S
S
K
L
G
I
T
M
T
Site 31
Y399
P
E
L
K
V
G
D
Y
F
F
G
K
C
F
D
Site 32
S416
E
V
D
A
L
N
S
S
H
P
V
S
T
P
V
Site 33
S420
L
N
S
S
H
P
V
S
T
P
V
E
N
P
A
Site 34
T421
N
S
S
H
P
V
S
T
P
V
E
N
P
A
Q
Site 35
Y438
E
M
F
D
D
V
S
Y
D
K
G
A
C
I
L
Site 36
S453
N
M
L
R
E
Y
L
S
A
D
A
F
K
S
G
Site 37
Y464
F
K
S
G
I
V
Q
Y
L
Q
K
H
S
Y
K
Site 38
Y470
Q
Y
L
Q
K
H
S
Y
K
N
T
K
N
E
D
Site 39
T473
Q
K
H
S
Y
K
N
T
K
N
E
D
L
W
D
Site 40
T488
S
M
A
S
I
C
P
T
D
G
V
K
G
M
D
Site 41
S499
K
G
M
D
G
F
C
S
R
S
Q
H
S
S
S
Site 42
S501
M
D
G
F
C
S
R
S
Q
H
S
S
S
S
S
Site 43
S504
F
C
S
R
S
Q
H
S
S
S
S
S
H
W
H
Site 44
S505
C
S
R
S
Q
H
S
S
S
S
S
H
W
H
Q
Site 45
S506
S
R
S
Q
H
S
S
S
S
S
H
W
H
Q
E
Site 46
S507
R
S
Q
H
S
S
S
S
S
H
W
H
Q
E
G
Site 47
S508
S
Q
H
S
S
S
S
S
H
W
H
Q
E
G
V
Site 48
Y549
V
H
M
K
Q
E
H
Y
M
K
G
S
D
G
A
Site 49
T559
G
S
D
G
A
P
D
T
G
Y
L
W
H
V
P
Site 50
Y561
D
G
A
P
D
T
G
Y
L
W
H
V
P
L
T
Site 51
T568
Y
L
W
H
V
P
L
T
F
I
T
S
K
S
D
Site 52
S572
V
P
L
T
F
I
T
S
K
S
D
M
V
H
R
Site 53
Y607
F
N
V
G
M
N
G
Y
Y
I
V
H
Y
E
D
Site 54
Y608
N
V
G
M
N
G
Y
Y
I
V
H
Y
E
D
D
Site 55
Y612
N
G
Y
Y
I
V
H
Y
E
D
D
G
W
D
S
Site 56
S619
Y
E
D
D
G
W
D
S
L
T
G
L
L
K
G
Site 57
T621
D
D
G
W
D
S
L
T
G
L
L
K
G
T
H
Site 58
T629
G
L
L
K
G
T
H
T
A
V
S
S
N
D
R
Site 59
S632
K
G
T
H
T
A
V
S
S
N
D
R
A
S
L
Site 60
S633
G
T
H
T
A
V
S
S
N
D
R
A
S
L
I
Site 61
S638
V
S
S
N
D
R
A
S
L
I
N
N
A
F
Q
Site 62
S661
I
E
K
A
L
D
L
S
L
Y
L
K
H
E
T
Site 63
Y663
K
A
L
D
L
S
L
Y
L
K
H
E
T
E
I
Site 64
Y684
L
N
E
L
I
P
M
Y
K
L
M
E
K
R
D
Site 65
T715
R
D
L
I
D
K
Q
T
W
T
D
E
G
S
V
Site 66
T717
L
I
D
K
Q
T
W
T
D
E
G
S
V
S
E
Site 67
S721
Q
T
W
T
D
E
G
S
V
S
E
R
M
L
R
Site 68
S723
W
T
D
E
G
S
V
S
E
R
M
L
R
S
Q
Site 69
Y750
C
V
Q
R
A
E
G
Y
F
R
K
W
K
E
S
Site 70
S757
Y
F
R
K
W
K
E
S
N
G
N
L
S
L
P
Site 71
S762
K
E
S
N
G
N
L
S
L
P
V
D
V
T
L
Site 72
Y786
T
E
G
W
D
F
L
Y
S
K
Y
Q
F
S
L
Site 73
Y789
W
D
F
L
Y
S
K
Y
Q
F
S
L
S
S
T
Site 74
S792
L
Y
S
K
Y
Q
F
S
L
S
S
T
E
K
S
Site 75
S794
S
K
Y
Q
F
S
L
S
S
T
E
K
S
Q
I
Site 76
S795
K
Y
Q
F
S
L
S
S
T
E
K
S
Q
I
E
Site 77
T796
Y
Q
F
S
L
S
S
T
E
K
S
Q
I
E
F
Site 78
S799
S
L
S
S
T
E
K
S
Q
I
E
F
A
L
C
Site 79
S821
L
Q
W
L
L
D
E
S
F
K
G
D
K
I
K
Site 80
T829
F
K
G
D
K
I
K
T
Q
E
F
P
Q
I
L
Site 81
S883
M
G
T
T
N
Q
F
S
T
R
T
R
L
E
E
Site 82
S897
E
V
K
G
F
F
S
S
L
K
E
N
G
S
Q
Site 83
S903
S
S
L
K
E
N
G
S
Q
L
R
C
V
Q
Q
Site 84
T911
Q
L
R
C
V
Q
Q
T
I
E
T
I
E
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation