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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RTEL1
Full Name:
Regulator of telomere elongation helicase 1
Alias:
C20orf41; EC 3.6.1.-; Helicase-like NHL; KIAA1088; NHL; Novel helicase-like; Regulator of telomere length; RTEL; TNFRSF6B
Type:
DNA repair, Helicase
Mass (Da):
152374
Number AA:
1400
UniProt ID:
Q9NZ71
International Prot ID:
IPI00219849
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0010569
GO:0000723
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
V
D
F
P
F
Q
P
Y
K
C
Q
Q
E
Y
M
Site 2
Y24
P
Y
K
C
Q
Q
E
Y
M
T
K
V
L
E
C
Site 3
S42
K
V
N
G
I
L
E
S
P
T
G
T
G
K
T
Site 4
S68
E
H
L
R
D
G
I
S
A
R
K
I
A
E
R
Site 5
S87
L
F
P
D
R
A
L
S
S
W
G
N
A
A
A
Site 6
S88
F
P
D
R
A
L
S
S
W
G
N
A
A
A
A
Site 7
Y111
T
D
I
P
K
I
I
Y
A
S
R
T
H
S
Q
Site 8
S113
I
P
K
I
I
Y
A
S
R
T
H
S
Q
L
T
Site 9
S117
I
Y
A
S
R
T
H
S
Q
L
T
Q
V
I
N
Site 10
T120
S
R
T
H
S
Q
L
T
Q
V
I
N
E
L
R
Site 11
T129
V
I
N
E
L
R
N
T
S
Y
R
P
K
V
C
Site 12
S130
I
N
E
L
R
N
T
S
Y
R
P
K
V
C
V
Site 13
Y175
A
S
R
S
C
H
F
Y
N
N
V
E
E
K
S
Site 14
S182
Y
N
N
V
E
E
K
S
L
E
Q
E
L
A
S
Site 15
S189
S
L
E
Q
E
L
A
S
P
I
L
D
I
E
D
Site 16
S200
D
I
E
D
L
V
K
S
G
S
K
H
R
V
C
Site 17
S202
E
D
L
V
K
S
G
S
K
H
R
V
C
P
Y
Site 18
Y209
S
K
H
R
V
C
P
Y
Y
L
S
R
N
L
K
Site 19
Y210
K
H
R
V
C
P
Y
Y
L
S
R
N
L
K
Q
Site 20
S212
R
V
C
P
Y
Y
L
S
R
N
L
K
Q
Q
A
Site 21
S234
N
Y
L
L
D
A
K
S
R
R
A
H
N
I
D
Site 22
S262
V
E
K
M
C
E
E
S
A
S
F
D
L
T
P
Site 23
S264
K
M
C
E
E
S
A
S
F
D
L
T
P
H
D
Site 24
T268
E
S
A
S
F
D
L
T
P
H
D
L
A
S
G
Site 25
S300
G
E
P
H
P
E
F
S
A
D
S
P
S
P
G
Site 26
S303
H
P
E
F
S
A
D
S
P
S
P
G
L
N
M
Site 27
S305
E
F
S
A
D
S
P
S
P
G
L
N
M
E
L
Site 28
S339
V
E
L
P
G
D
D
S
G
V
T
K
P
G
S
Site 29
T342
P
G
D
D
S
G
V
T
K
P
G
S
Y
I
F
Site 30
Y347
G
V
T
K
P
G
S
Y
I
F
E
L
F
A
E
Site 31
T361
E
A
Q
I
T
F
Q
T
K
G
C
I
L
D
S
Site 32
S368
T
K
G
C
I
L
D
S
L
D
Q
I
I
Q
H
Site 33
T384
A
G
R
A
G
V
F
T
N
T
A
G
L
Q
K
Site 34
S405
I
V
F
S
V
D
P
S
E
G
S
P
G
S
P
Site 35
S408
S
V
D
P
S
E
G
S
P
G
S
P
A
G
L
Site 36
S411
P
S
E
G
S
P
G
S
P
A
G
L
G
A
L
Site 37
T434
P
D
A
G
H
R
R
T
A
Q
R
S
D
A
W
Site 38
S438
H
R
R
T
A
Q
R
S
D
A
W
S
T
T
A
Site 39
S442
A
Q
R
S
D
A
W
S
T
T
A
A
R
K
R
Site 40
S454
R
K
R
G
K
V
L
S
Y
W
C
F
S
P
G
Site 41
Y455
K
R
G
K
V
L
S
Y
W
C
F
S
P
G
H
Site 42
S526
G
P
D
G
A
Q
L
S
S
A
F
D
R
R
F
Site 43
S527
P
D
G
A
Q
L
S
S
A
F
D
R
R
F
S
Site 44
S534
S
A
F
D
R
R
F
S
E
E
C
L
S
S
L
Site 45
S539
R
F
S
E
E
C
L
S
S
L
G
K
A
L
G
Site 46
S540
F
S
E
E
C
L
S
S
L
G
K
A
L
G
N
Site 47
S569
S
Y
P
V
M
E
K
S
L
E
F
W
R
A
R
Site 48
S594
P
L
F
V
E
P
R
S
K
G
S
F
S
E
T
Site 49
S597
V
E
P
R
S
K
G
S
F
S
E
T
I
S
A
Site 50
S599
P
R
S
K
G
S
F
S
E
T
I
S
A
Y
Y
Site 51
T601
S
K
G
S
F
S
E
T
I
S
A
Y
Y
A
R
Site 52
S603
G
S
F
S
E
T
I
S
A
Y
Y
A
R
V
A
Site 53
Y606
S
E
T
I
S
A
Y
Y
A
R
V
A
A
P
G
Site 54
S634
A
S
E
G
L
D
F
S
D
T
N
G
R
G
V
Site 55
T636
E
G
L
D
F
S
D
T
N
G
R
G
V
I
V
Site 56
T644
N
G
R
G
V
I
V
T
G
L
P
Y
P
P
R
Site 57
Y648
V
I
V
T
G
L
P
Y
P
P
R
M
D
P
R
Site 58
S678
G
A
G
G
Q
F
L
S
G
Q
E
W
Y
R
Q
Site 59
Y705
V
I
R
H
R
Q
D
Y
G
A
V
F
L
C
D
Site 60
S726
D
A
R
A
Q
L
P
S
W
V
R
P
H
V
R
Site 61
Y735
V
R
P
H
V
R
V
Y
D
N
F
G
H
V
I
Site 62
T764
P
A
P
A
P
R
A
T
A
P
S
V
R
G
E
Site 63
S767
A
P
R
A
T
A
P
S
V
R
G
E
D
A
V
Site 64
S775
V
R
G
E
D
A
V
S
E
A
K
S
P
G
P
Site 65
S779
D
A
V
S
E
A
K
S
P
G
P
F
F
S
T
Site 66
S785
K
S
P
G
P
F
F
S
T
R
K
A
K
S
L
Site 67
T786
S
P
G
P
F
F
S
T
R
K
A
K
S
L
D
Site 68
S791
F
S
T
R
K
A
K
S
L
D
L
H
V
P
S
Site 69
S798
S
L
D
L
H
V
P
S
L
K
Q
R
S
S
G
Site 70
S804
P
S
L
K
Q
R
S
S
G
S
P
A
A
G
D
Site 71
S806
L
K
Q
R
S
S
G
S
P
A
A
G
D
P
E
Site 72
S814
P
A
A
G
D
P
E
S
S
L
C
V
E
Y
E
Site 73
S815
A
A
G
D
P
E
S
S
L
C
V
E
Y
E
Q
Site 74
S847
H
S
E
Q
R
A
G
S
P
G
E
E
Q
A
H
Site 75
S855
P
G
E
E
Q
A
H
S
C
S
T
L
S
L
L
Site 76
S857
E
E
Q
A
H
S
C
S
T
L
S
L
L
S
E
Site 77
S860
A
H
S
C
S
T
L
S
L
L
S
E
K
R
P
Site 78
S863
C
S
T
L
S
L
L
S
E
K
R
P
A
E
E
Site 79
S882
R
K
K
I
R
L
V
S
H
P
E
E
P
V
A
Site 80
T893
E
P
V
A
G
A
Q
T
D
R
A
K
L
F
M
Site 81
T914
L
S
Q
A
N
F
A
T
F
T
Q
A
L
Q
D
Site 82
Y922
F
T
Q
A
L
Q
D
Y
K
G
S
D
D
F
A
Site 83
Y953
H
N
L
L
Q
G
F
Y
Q
F
V
R
P
H
H
Site 84
T972
E
E
V
C
I
Q
L
T
G
R
G
C
G
Y
R
Site 85
S983
C
G
Y
R
P
E
H
S
I
P
R
R
Q
R
A
Site 86
T997
A
Q
P
V
L
D
P
T
G
R
T
A
P
D
P
Site 87
T1007
T
A
P
D
P
K
L
T
V
S
T
A
A
A
Q
Site 88
S1009
P
D
P
K
L
T
V
S
T
A
A
A
Q
Q
L
Site 89
S1030
N
Q
G
R
P
H
L
S
P
R
P
P
P
T
G
Site 90
T1036
L
S
P
R
P
P
P
T
G
D
P
G
S
Q
P
Site 91
S1041
P
P
T
G
D
P
G
S
Q
P
Q
W
G
S
G
Site 92
S1047
G
S
Q
P
Q
W
G
S
G
V
P
R
A
G
K
Site 93
S1073
D
A
R
R
A
L
G
S
A
G
C
S
Q
L
L
Site 94
T1084
S
Q
L
L
A
A
L
T
A
Y
K
Q
D
D
D
Site 95
T1103
L
A
V
L
A
A
L
T
T
A
K
P
E
D
F
Site 96
T1104
A
V
L
A
A
L
T
T
A
K
P
E
D
F
P
Site 97
S1129
P
H
H
K
Q
R
F
S
Q
T
C
T
D
L
T
Site 98
T1133
Q
R
F
S
Q
T
C
T
D
L
T
G
R
P
Y
Site 99
T1136
S
Q
T
C
T
D
L
T
G
R
P
Y
P
G
M
Site 100
Y1140
T
D
L
T
G
R
P
Y
P
G
M
E
P
P
G
Site 101
S1169
R
A
P
Q
P
G
P
S
R
S
E
K
T
G
K
Site 102
S1171
P
Q
P
G
P
S
R
S
E
K
T
G
K
T
Q
Site 103
T1177
R
S
E
K
T
G
K
T
Q
S
K
I
S
S
F
Site 104
S1179
E
K
T
G
K
T
Q
S
K
I
S
S
F
L
R
Site 105
S1183
K
T
Q
S
K
I
S
S
F
L
R
Q
R
P
A
Site 106
T1192
L
R
Q
R
P
A
G
T
V
G
A
G
G
E
D
Site 107
S1203
G
G
E
D
A
G
P
S
Q
S
S
G
P
P
H
Site 108
S1205
E
D
A
G
P
S
Q
S
S
G
P
P
H
G
P
Site 109
S1206
D
A
G
P
S
Q
S
S
G
P
P
H
G
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation