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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTTG2
Full Name:
Securin-2
Alias:
Pituitary tumor transforming gene protein 2; Pituitary tumor-transforming 2; Pttg2
Type:
Cytoplasm, Nucleus protein
Mass (Da):
22243
Number AA:
202
UniProt ID:
Q9NZH5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0017124
PhosphoSite+
KinaseNET
Biological Process:
GO:0006259
GO:0051276
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
L
K
L
E
S
R
P
S
I
K
A
L
D
G
I
Site 2
T43
D
G
I
S
Q
V
L
T
P
R
F
G
K
T
Y
Site 3
T49
L
T
P
R
F
G
K
T
Y
D
A
P
S
A
L
Site 4
Y50
T
P
R
F
G
K
T
Y
D
A
P
S
A
L
P
Site 5
S54
G
K
T
Y
D
A
P
S
A
L
P
K
A
T
R
Site 6
T66
A
T
R
K
A
L
G
T
V
N
R
A
T
E
K
Site 7
T71
L
G
T
V
N
R
A
T
E
K
S
V
K
T
N
Site 8
S74
V
N
R
A
T
E
K
S
V
K
T
N
G
P
R
Site 9
T77
A
T
E
K
S
V
K
T
N
G
P
R
K
Q
K
Site 10
S87
P
R
K
Q
K
Q
P
S
F
S
A
K
K
M
T
Site 11
T97
A
K
K
M
T
E
K
T
V
K
T
K
S
S
V
Site 12
T100
M
T
E
K
T
V
K
T
K
S
S
V
P
A
S
Site 13
S102
E
K
T
V
K
T
K
S
S
V
P
A
S
D
D
Site 14
S103
K
T
V
K
T
K
S
S
V
P
A
S
D
D
A
Site 15
S107
T
K
S
S
V
P
A
S
D
D
A
Y
P
E
I
Site 16
Y111
V
P
A
S
D
D
A
Y
P
E
I
E
K
F
F
Site 17
S127
F
N
L
L
D
F
E
S
F
D
L
P
E
E
R
Site 18
S165
L
F
Q
L
G
P
P
S
P
V
K
M
P
S
P
Site 19
S171
P
S
P
V
K
M
P
S
P
P
W
E
C
N
L
Site 20
S181
W
E
C
N
L
L
Q
S
P
S
S
I
L
S
T
Site 21
S187
Q
S
P
S
S
I
L
S
T
L
D
V
E
L
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation