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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CNOT2
Full Name:
CCR4-NOT transcription complex subunit 2
Alias:
CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; CDC36; HSPC131; MSTP046; NOT2; NOT2 (negative regulator of transcription 2, yeast) homolog; NOT2H
Type:
Transcription, coactivator/corepressor
Mass (Da):
59738
Number AA:
540
UniProt ID:
Q9NZN8
International Prot ID:
IPI00005011
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0016455
GO:0005515
GO:0016455
PhosphoSite+
KinaseNET
Biological Process:
GO:0006358
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
V
R
T
D
G
H
T
L
S
E
K
R
N
Y
Site 2
S10
R
T
D
G
H
T
L
S
E
K
R
N
Y
Q
V
Site 3
Y15
T
L
S
E
K
R
N
Y
Q
V
T
N
S
M
F
Site 4
T18
E
K
R
N
Y
Q
V
T
N
S
M
F
G
A
S
Site 5
S20
R
N
Y
Q
V
T
N
S
M
F
G
A
S
R
K
Site 6
S35
K
F
V
E
G
V
D
S
D
Y
H
D
E
N
M
Site 7
Y37
V
E
G
V
D
S
D
Y
H
D
E
N
M
Y
Y
Site 8
Y43
D
Y
H
D
E
N
M
Y
Y
S
Q
S
S
M
F
Site 9
Y44
Y
H
D
E
N
M
Y
Y
S
Q
S
S
M
F
P
Site 10
S45
H
D
E
N
M
Y
Y
S
Q
S
S
M
F
P
H
Site 11
S47
E
N
M
Y
Y
S
Q
S
S
M
F
P
H
R
S
Site 12
S48
N
M
Y
Y
S
Q
S
S
M
F
P
H
R
S
E
Site 13
S54
S
S
M
F
P
H
R
S
E
K
D
M
L
A
S
Site 14
S61
S
E
K
D
M
L
A
S
P
S
T
S
G
Q
L
Site 15
S63
K
D
M
L
A
S
P
S
T
S
G
Q
L
S
Q
Site 16
S65
M
L
A
S
P
S
T
S
G
Q
L
S
Q
F
G
Site 17
S69
P
S
T
S
G
Q
L
S
Q
F
G
A
S
L
Y
Site 18
S74
Q
L
S
Q
F
G
A
S
L
Y
G
Q
Q
S
A
Site 19
Y76
S
Q
F
G
A
S
L
Y
G
Q
Q
S
A
L
G
Site 20
S80
A
S
L
Y
G
Q
Q
S
A
L
G
L
P
M
R
Site 21
S90
G
L
P
M
R
G
M
S
N
N
T
P
Q
L
N
Site 22
T93
M
R
G
M
S
N
N
T
P
Q
L
N
R
S
L
Site 23
S99
N
T
P
Q
L
N
R
S
L
S
Q
G
T
Q
L
Site 24
S101
P
Q
L
N
R
S
L
S
Q
G
T
Q
L
P
S
Site 25
T104
N
R
S
L
S
Q
G
T
Q
L
P
S
H
V
T
Site 26
S108
S
Q
G
T
Q
L
P
S
H
V
T
P
T
T
G
Site 27
T111
T
Q
L
P
S
H
V
T
P
T
T
G
V
P
T
Site 28
T113
L
P
S
H
V
T
P
T
T
G
V
P
T
M
S
Site 29
T114
P
S
H
V
T
P
T
T
G
V
P
T
M
S
L
Site 30
T118
T
P
T
T
G
V
P
T
M
S
L
H
T
P
P
Site 31
S120
T
T
G
V
P
T
M
S
L
H
T
P
P
S
P
Site 32
T123
V
P
T
M
S
L
H
T
P
P
S
P
S
R
G
Site 33
S126
M
S
L
H
T
P
P
S
P
S
R
G
I
L
P
Site 34
S128
L
H
T
P
P
S
P
S
R
G
I
L
P
M
N
Site 35
S153
G
Q
G
I
G
I
P
S
R
T
N
S
M
S
S
Site 36
T155
G
I
G
I
P
S
R
T
N
S
M
S
S
S
G
Site 37
S157
G
I
P
S
R
T
N
S
M
S
S
S
G
L
G
Site 38
S159
P
S
R
T
N
S
M
S
S
S
G
L
G
S
P
Site 39
S160
S
R
T
N
S
M
S
S
S
G
L
G
S
P
N
Site 40
S161
R
T
N
S
M
S
S
S
G
L
G
S
P
N
R
Site 41
S165
M
S
S
S
G
L
G
S
P
N
R
S
S
P
S
Site 42
S169
G
L
G
S
P
N
R
S
S
P
S
I
I
C
M
Site 43
S170
L
G
S
P
N
R
S
S
P
S
I
I
C
M
P
Site 44
S172
S
P
N
R
S
S
P
S
I
I
C
M
P
K
Q
Site 45
T187
Q
P
S
R
Q
P
F
T
V
N
S
M
S
G
F
Site 46
S190
R
Q
P
F
T
V
N
S
M
S
G
F
G
M
N
Site 47
S207
Q
A
F
G
M
N
N
S
L
S
S
N
I
F
N
Site 48
S209
F
G
M
N
N
S
L
S
S
N
I
F
N
G
T
Site 49
S219
I
F
N
G
T
D
G
S
E
N
V
T
G
L
D
Site 50
T223
T
D
G
S
E
N
V
T
G
L
D
L
S
D
F
Site 51
S242
D
R
N
R
R
E
G
S
G
N
P
T
P
L
I
Site 52
T246
R
E
G
S
G
N
P
T
P
L
I
N
P
L
A
Site 53
S270
T
K
P
A
N
E
Q
S
Q
D
F
S
I
H
N
Site 54
S274
N
E
Q
S
Q
D
F
S
I
H
N
E
D
F
P
Site 55
S286
D
F
P
A
L
P
G
S
S
Y
K
D
P
T
S
Site 56
S287
F
P
A
L
P
G
S
S
Y
K
D
P
T
S
S
Site 57
Y288
P
A
L
P
G
S
S
Y
K
D
P
T
S
S
N
Site 58
T292
G
S
S
Y
K
D
P
T
S
S
N
D
D
S
K
Site 59
S293
S
S
Y
K
D
P
T
S
S
N
D
D
S
K
S
Site 60
S294
S
Y
K
D
P
T
S
S
N
D
D
S
K
S
N
Site 61
S298
P
T
S
S
N
D
D
S
K
S
N
L
N
T
S
Site 62
S300
S
S
N
D
D
S
K
S
N
L
N
T
S
G
K
Site 63
T304
D
S
K
S
N
L
N
T
S
G
K
T
T
S
S
Site 64
S305
S
K
S
N
L
N
T
S
G
K
T
T
S
S
T
Site 65
T309
L
N
T
S
G
K
T
T
S
S
T
D
G
P
K
Site 66
S310
N
T
S
G
K
T
T
S
S
T
D
G
P
K
F
Site 67
S311
T
S
G
K
T
T
S
S
T
D
G
P
K
F
P
Site 68
T312
S
G
K
T
T
S
S
T
D
G
P
K
F
P
G
Site 69
S322
P
K
F
P
G
D
K
S
S
T
T
Q
N
N
N
Site 70
S323
K
F
P
G
D
K
S
S
T
T
Q
N
N
N
Q
Site 71
T325
P
G
D
K
S
S
T
T
Q
N
N
N
Q
Q
K
Site 72
S391
T
L
G
L
N
L
N
S
P
E
N
L
Y
P
K
Site 73
Y396
L
N
S
P
E
N
L
Y
P
K
F
A
S
P
W
Site 74
S401
N
L
Y
P
K
F
A
S
P
W
A
S
S
P
C
Site 75
S405
K
F
A
S
P
W
A
S
S
P
C
R
P
Q
D
Site 76
S406
F
A
S
P
W
A
S
S
P
C
R
P
Q
D
I
Site 77
Y421
D
F
H
V
P
S
E
Y
L
T
N
I
H
I
R
Site 78
T423
H
V
P
S
E
Y
L
T
N
I
H
I
R
D
K
Site 79
Y446
Y
G
E
D
L
L
F
Y
L
Y
Y
M
N
G
G
Site 80
T480
K
E
E
R
V
W
I
T
R
A
P
G
M
E
P
Site 81
T493
E
P
T
M
K
T
N
T
Y
E
R
G
T
Y
Y
Site 82
Y494
P
T
M
K
T
N
T
Y
E
R
G
T
Y
Y
F
Site 83
Y499
N
T
Y
E
R
G
T
Y
Y
F
F
D
C
L
N
Site 84
Y500
T
Y
E
R
G
T
Y
Y
F
F
D
C
L
N
W
Site 85
Y518
A
K
E
F
H
L
E
Y
D
K
L
E
E
R
P
Site 86
S529
E
E
R
P
H
L
P
S
T
F
N
Y
N
P
A
Site 87
T530
E
R
P
H
L
P
S
T
F
N
Y
N
P
A
Q
Site 88
Y533
H
L
P
S
T
F
N
Y
N
P
A
Q
Q
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation