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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DSPP
Full Name:
Dentin sialophosphoprotein
Alias:
Dentin phosphophoryn; Dentin phosphoprotein; Dentin sialophosphoprotein; DFNA39; DGI1; DMP3; DPP; DSP
Type:
Extracellular matrix protein
Mass (Da):
126428
Number AA:
1253
UniProt ID:
Q9NZW4
International Prot ID:
IPI00003323
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005518
GO:0005201
PhosphoSite+
KinaseNET
Biological Process:
GO:0031214
GO:0001503
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
W
A
I
P
V
P
Q
S
K
P
L
E
R
H
V
Site 2
S31
L
E
R
H
V
E
K
S
M
N
L
H
L
L
A
Site 3
S51
V
Q
D
E
L
N
A
S
G
T
I
K
E
S
G
Site 4
T53
D
E
L
N
A
S
G
T
I
K
E
S
G
V
L
Site 5
S57
A
S
G
T
I
K
E
S
G
V
L
V
H
E
G
Site 6
S83
H
K
G
E
G
N
G
S
K
W
A
E
V
G
G
Site 7
S92
W
A
E
V
G
G
K
S
F
S
T
Y
S
T
L
Site 8
S94
E
V
G
G
K
S
F
S
T
Y
S
T
L
A
N
Site 9
Y96
G
G
K
S
F
S
T
Y
S
T
L
A
N
E
E
Site 10
S97
G
K
S
F
S
T
Y
S
T
L
A
N
E
E
G
Site 11
T98
K
S
F
S
T
Y
S
T
L
A
N
E
E
G
N
Site 12
Y119
D
T
G
K
A
E
T
Y
G
H
D
G
I
H
G
Site 13
T132
H
G
K
E
E
N
I
T
A
N
G
I
Q
G
Q
Site 14
T154
G
A
T
N
R
S
N
T
N
G
N
T
D
K
N
Site 15
T162
N
G
N
T
D
K
N
T
Q
N
G
D
V
G
D
Site 16
S189
D
G
P
Q
V
A
G
S
N
N
S
T
D
N
E
Site 17
T193
V
A
G
S
N
N
S
T
D
N
E
D
E
I
I
Site 18
S203
E
D
E
I
I
E
N
S
C
R
N
E
G
N
T
Site 19
T210
S
C
R
N
E
G
N
T
S
E
I
T
P
Q
I
Site 20
S211
C
R
N
E
G
N
T
S
E
I
T
P
Q
I
N
Site 21
T214
E
G
N
T
S
E
I
T
P
Q
I
N
S
K
R
Site 22
S219
E
I
T
P
Q
I
N
S
K
R
N
G
T
K
E
Site 23
T224
I
N
S
K
R
N
G
T
K
E
A
E
V
T
P
Site 24
T230
G
T
K
E
A
E
V
T
P
G
T
G
E
D
A
Site 25
S242
E
D
A
G
L
D
N
S
D
G
S
P
S
G
N
Site 26
S245
G
L
D
N
S
D
G
S
P
S
G
N
G
A
D
Site 27
S259
D
E
D
E
D
E
G
S
G
D
D
E
D
E
E
Site 28
S273
E
A
G
N
G
K
D
S
S
N
N
S
K
G
Q
Site 29
S274
A
G
N
G
K
D
S
S
N
N
S
K
G
Q
E
Site 30
S277
G
K
D
S
S
N
N
S
K
G
Q
E
G
Q
D
Site 31
S293
G
K
E
D
D
H
D
S
S
I
G
Q
N
S
D
Site 32
S294
K
E
D
D
H
D
S
S
I
G
Q
N
S
D
S
Site 33
S299
D
S
S
I
G
Q
N
S
D
S
K
E
Y
Y
D
Site 34
S301
S
I
G
Q
N
S
D
S
K
E
Y
Y
D
P
E
Site 35
Y304
Q
N
S
D
S
K
E
Y
Y
D
P
E
G
K
E
Site 36
Y305
N
S
D
S
K
E
Y
Y
D
P
E
G
K
E
D
Site 37
T322
N
E
V
D
G
D
K
T
S
K
S
E
E
N
S
Site 38
S323
E
V
D
G
D
K
T
S
K
S
E
E
N
S
A
Site 39
S325
D
G
D
K
T
S
K
S
E
E
N
S
A
G
I
Site 40
S329
T
S
K
S
E
E
N
S
A
G
I
P
E
D
N
Site 41
S338
G
I
P
E
D
N
G
S
Q
R
I
E
D
T
Q
Site 42
S352
Q
K
L
N
H
R
E
S
K
R
V
E
N
R
I
Site 43
T360
K
R
V
E
N
R
I
T
K
E
S
E
T
H
A
Site 44
S363
E
N
R
I
T
K
E
S
E
T
H
A
V
G
K
Site 45
S371
E
T
H
A
V
G
K
S
Q
D
K
G
I
E
I
Site 46
S383
I
E
I
K
G
P
S
S
G
N
R
N
I
T
K
Site 47
T389
S
S
G
N
R
N
I
T
K
E
V
G
K
G
N
Site 48
T416
L
G
K
G
N
V
K
T
Q
G
E
V
V
N
I
Site 49
S430
I
E
G
P
G
Q
K
S
E
P
G
N
K
V
G
Site 50
S439
P
G
N
K
V
G
H
S
N
T
G
S
D
S
N
Site 51
T441
N
K
V
G
H
S
N
T
G
S
D
S
N
S
D
Site 52
S443
V
G
H
S
N
T
G
S
D
S
N
S
D
G
Y
Site 53
S445
H
S
N
T
G
S
D
S
N
S
D
G
Y
D
S
Site 54
S447
N
T
G
S
D
S
N
S
D
G
Y
D
S
Y
D
Site 55
Y450
S
D
S
N
S
D
G
Y
D
S
Y
D
F
D
D
Site 56
S452
S
N
S
D
G
Y
D
S
Y
D
F
D
D
K
S
Site 57
Y453
N
S
D
G
Y
D
S
Y
D
F
D
D
K
S
M
Site 58
S459
S
Y
D
F
D
D
K
S
M
Q
G
D
D
P
N
Site 59
S467
M
Q
G
D
D
P
N
S
S
D
E
S
N
G
N
Site 60
S468
Q
G
D
D
P
N
S
S
D
E
S
N
G
N
D
Site 61
S471
D
P
N
S
S
D
E
S
N
G
N
D
D
A
N
Site 62
S479
N
G
N
D
D
A
N
S
E
S
D
N
N
S
S
Site 63
S481
N
D
D
A
N
S
E
S
D
N
N
S
S
S
R
Site 64
S485
N
S
E
S
D
N
N
S
S
S
R
G
D
A
S
Site 65
S486
S
E
S
D
N
N
S
S
S
R
G
D
A
S
Y
Site 66
S487
E
S
D
N
N
S
S
S
R
G
D
A
S
Y
N
Site 67
S492
S
S
S
R
G
D
A
S
Y
N
S
D
E
S
K
Site 68
Y493
S
S
R
G
D
A
S
Y
N
S
D
E
S
K
D
Site 69
S495
R
G
D
A
S
Y
N
S
D
E
S
K
D
N
G
Site 70
S498
A
S
Y
N
S
D
E
S
K
D
N
G
N
G
S
Site 71
S505
S
K
D
N
G
N
G
S
D
S
K
G
A
E
D
Site 72
S507
D
N
G
N
G
S
D
S
K
G
A
E
D
D
D
Site 73
S515
K
G
A
E
D
D
D
S
D
S
T
S
D
T
N
Site 74
S517
A
E
D
D
D
S
D
S
T
S
D
T
N
N
S
Site 75
S519
D
D
D
S
D
S
T
S
D
T
N
N
S
D
S
Site 76
T521
D
S
D
S
T
S
D
T
N
N
S
D
S
N
G
Site 77
S524
S
T
S
D
T
N
N
S
D
S
N
G
N
G
N
Site 78
S526
S
D
T
N
N
S
D
S
N
G
N
G
N
N
G
Site 79
S540
G
N
D
D
N
D
K
S
D
S
G
K
G
K
S
Site 80
S542
D
D
N
D
K
S
D
S
G
K
G
K
S
D
S
Site 81
S547
S
D
S
G
K
G
K
S
D
S
S
D
S
D
S
Site 82
S549
S
G
K
G
K
S
D
S
S
D
S
D
S
S
D
Site 83
S550
G
K
G
K
S
D
S
S
D
S
D
S
S
D
S
Site 84
S552
G
K
S
D
S
S
D
S
D
S
S
D
S
S
N
Site 85
S554
S
D
S
S
D
S
D
S
S
D
S
S
N
S
S
Site 86
S555
D
S
S
D
S
D
S
S
D
S
S
N
S
S
D
Site 87
S557
S
D
S
D
S
S
D
S
S
N
S
S
D
S
S
Site 88
S558
D
S
D
S
S
D
S
S
N
S
S
D
S
S
D
Site 89
S560
D
S
S
D
S
S
N
S
S
D
S
S
D
S
S
Site 90
S561
S
S
D
S
S
N
S
S
D
S
S
D
S
S
D
Site 91
S563
D
S
S
N
S
S
D
S
S
D
S
S
D
S
D
Site 92
S564
S
S
N
S
S
D
S
S
D
S
S
D
S
D
S
Site 93
S566
N
S
S
D
S
S
D
S
S
D
S
D
S
S
D
Site 94
S567
S
S
D
S
S
D
S
S
D
S
D
S
S
D
S
Site 95
S569
D
S
S
D
S
S
D
S
D
S
S
D
S
N
S
Site 96
S571
S
D
S
S
D
S
D
S
S
D
S
N
S
S
S
Site 97
S572
D
S
S
D
S
D
S
S
D
S
N
S
S
S
D
Site 98
S574
S
D
S
D
S
S
D
S
N
S
S
S
D
S
D
Site 99
S576
S
D
S
S
D
S
N
S
S
S
D
S
D
S
S
Site 100
S577
D
S
S
D
S
N
S
S
S
D
S
D
S
S
D
Site 101
S578
S
S
D
S
N
S
S
S
D
S
D
S
S
D
S
Site 102
S580
D
S
N
S
S
S
D
S
D
S
S
D
S
D
S
Site 103
S582
N
S
S
S
D
S
D
S
S
D
S
D
S
S
D
Site 104
S583
S
S
S
D
S
D
S
S
D
S
D
S
S
D
S
Site 105
S585
S
D
S
D
S
S
D
S
D
S
S
D
S
S
D
Site 106
S587
S
D
S
S
D
S
D
S
S
D
S
S
D
S
D
Site 107
S588
D
S
S
D
S
D
S
S
D
S
S
D
S
D
S
Site 108
S590
S
D
S
D
S
S
D
S
S
D
S
D
S
S
D
Site 109
S591
D
S
D
S
S
D
S
S
D
S
D
S
S
D
S
Site 110
S593
D
S
S
D
S
S
D
S
D
S
S
D
S
S
N
Site 111
S604
D
S
S
N
S
S
D
S
S
D
S
S
D
S
S
Site 112
S605
S
S
N
S
S
D
S
S
D
S
S
D
S
S
D
Site 113
S607
N
S
S
D
S
S
D
S
S
D
S
S
D
S
S
Site 114
S608
S
S
D
S
S
D
S
S
D
S
S
D
S
S
D
Site 115
S610
D
S
S
D
S
S
D
S
S
D
S
S
D
S
S
Site 116
S616
D
S
S
D
S
S
D
S
S
D
S
S
D
S
K
Site 117
S617
S
S
D
S
S
D
S
S
D
S
S
D
S
K
S
Site 118
S619
D
S
S
D
S
S
D
S
S
D
S
K
S
D
S
Site 119
S620
S
S
D
S
S
D
S
S
D
S
K
S
D
S
S
Site 120
S622
D
S
S
D
S
S
D
S
K
S
D
S
S
K
S
Site 121
S624
S
D
S
S
D
S
K
S
D
S
S
K
S
E
S
Site 122
S626
S
S
D
S
K
S
D
S
S
K
S
E
S
D
S
Site 123
S627
S
D
S
K
S
D
S
S
K
S
E
S
D
S
S
Site 124
S629
S
K
S
D
S
S
K
S
E
S
D
S
S
D
S
Site 125
S631
S
D
S
S
K
S
E
S
D
S
S
D
S
D
S
Site 126
S633
S
S
K
S
E
S
D
S
S
D
S
D
S
K
S
Site 127
S634
S
K
S
E
S
D
S
S
D
S
D
S
K
S
D
Site 128
S636
S
E
S
D
S
S
D
S
D
S
K
S
D
S
S
Site 129
S638
S
D
S
S
D
S
D
S
K
S
D
S
S
D
S
Site 130
S640
S
S
D
S
D
S
K
S
D
S
S
D
S
N
S
Site 131
S642
D
S
D
S
K
S
D
S
S
D
S
N
S
S
D
Site 132
S643
S
D
S
K
S
D
S
S
D
S
N
S
S
D
S
Site 133
S645
S
K
S
D
S
S
D
S
N
S
S
D
S
S
D
Site 134
S647
S
D
S
S
D
S
N
S
S
D
S
S
D
N
S
Site 135
S648
D
S
S
D
S
N
S
S
D
S
S
D
N
S
D
Site 136
S650
S
D
S
N
S
S
D
S
S
D
N
S
D
S
S
Site 137
S651
D
S
N
S
S
D
S
S
D
N
S
D
S
S
D
Site 138
S654
S
S
D
S
S
D
N
S
D
S
S
D
S
S
N
Site 139
S656
D
S
S
D
N
S
D
S
S
D
S
S
N
S
S
Site 140
S657
S
S
D
N
S
D
S
S
D
S
S
N
S
S
N
Site 141
S659
D
N
S
D
S
S
D
S
S
N
S
S
N
S
S
Site 142
S660
N
S
D
S
S
D
S
S
N
S
S
N
S
S
D
Site 143
S662
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S
S
D
S
S
D
S
N
E
S
S
D
S
S
Site 297
S1234
D
S
S
D
S
N
E
S
S
D
S
S
D
S
S
Site 298
S1235
S
S
D
S
N
E
S
S
D
S
S
D
S
S
D
Site 299
S1237
D
S
N
E
S
S
D
S
S
D
S
S
D
S
S
Site 300
S1238
S
N
E
S
S
D
S
S
D
S
S
D
S
S
D
Site 301
S1255
N
S
S
D
S
S
D
S
S
D
S
S
D
S
T
Site 302
S1256
S
S
D
S
S
D
S
S
D
S
S
D
S
T
S
Site 303
S1258
D
S
S
D
S
S
D
S
S
D
S
T
S
D
S
Site 304
S1259
S
S
D
S
S
D
S
S
D
S
T
S
D
S
N
Site 305
S1261
D
S
S
D
S
S
D
S
T
S
D
S
N
D
E
Site 306
T1262
S
S
D
S
S
D
S
T
S
D
S
N
D
E
S
Site 307
S1263
S
D
S
S
D
S
T
S
D
S
N
D
E
S
D
Site 308
S1265
S
S
D
S
T
S
D
S
N
D
E
S
D
S
Q
Site 309
S1269
T
S
D
S
N
D
E
S
D
S
Q
S
K
S
G
Site 310
S1271
D
S
N
D
E
S
D
S
Q
S
K
S
G
N
G
Site 311
S1273
N
D
E
S
D
S
Q
S
K
S
G
N
G
N
N
Site 312
S1275
E
S
D
S
Q
S
K
S
G
N
G
N
N
N
G
Site 313
S1283
G
N
G
N
N
N
G
S
D
S
D
S
D
S
E
Site 314
S1285
G
N
N
N
G
S
D
S
D
S
D
S
E
G
S
Site 315
S1287
N
N
G
S
D
S
D
S
D
S
E
G
S
D
S
Site 316
S1289
G
S
D
S
D
S
D
S
E
G
S
D
S
N
H
Site 317
S1292
S
D
S
D
S
E
G
S
D
S
N
H
S
T
S
Site 318
S1294
S
D
S
E
G
S
D
S
N
H
S
T
S
D
D
Site 319
S1297
E
G
S
D
S
N
H
S
T
S
D
D
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation