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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDP1
Full Name:
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Alias:
EC 3.1.3.43; PDP 1; PDPC 1; Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase, catalytic subunit 1
Type:
Protein-serine phosphatase
Mass (Da):
Number AA:
537
UniProt ID:
Q9P0J1
International Prot ID:
IPI00218971
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0008287
Uniprot
OncoNet
Molecular Function:
GO:0004741
GO:0005509
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S37
K
H
L
C
C
S
S
S
Y
I
P
Q
S
R
L
Site 2
S42
S
S
S
Y
I
P
Q
S
R
L
R
Y
T
P
H
Site 3
Y46
I
P
Q
S
R
L
R
Y
T
P
H
P
A
Y
A
Site 4
T47
P
Q
S
R
L
R
Y
T
P
H
P
A
Y
A
T
Site 5
Y52
R
Y
T
P
H
P
A
Y
A
T
F
C
R
P
K
Site 6
T54
T
P
H
P
A
Y
A
T
F
C
R
P
K
E
N
Site 7
Y71
Q
Y
T
Q
G
R
R
Y
A
S
T
P
Q
K
F
Site 8
S73
T
Q
G
R
R
Y
A
S
T
P
Q
K
F
Y
L
Site 9
T74
Q
G
R
R
Y
A
S
T
P
Q
K
F
Y
L
T
Site 10
Y79
A
S
T
P
Q
K
F
Y
L
T
P
P
Q
V
N
Site 11
T81
T
P
Q
K
F
Y
L
T
P
P
Q
V
N
S
I
Site 12
Y94
S
I
L
K
A
N
E
Y
S
F
K
V
P
E
F
Site 13
S95
I
L
K
A
N
E
Y
S
F
K
V
P
E
F
D
Site 14
S108
F
D
G
K
N
V
S
S
I
L
G
F
D
S
N
Site 15
S114
S
S
I
L
G
F
D
S
N
Q
L
P
A
N
A
Site 16
S128
A
P
I
E
D
R
R
S
A
A
T
C
L
Q
T
Site 17
S152
G
H
A
G
C
A
C
S
Q
A
V
S
E
R
L
Site 18
Y199
W
H
K
H
P
N
D
Y
F
S
K
E
A
S
K
Site 19
S201
K
H
P
N
D
Y
F
S
K
E
A
S
K
L
Y
Site 20
S205
D
Y
F
S
K
E
A
S
K
L
Y
F
N
S
L
Site 21
Y208
S
K
E
A
S
K
L
Y
F
N
S
L
R
T
Y
Site 22
S211
A
S
K
L
Y
F
N
S
L
R
T
Y
W
Q
E
Site 23
Y215
Y
F
N
S
L
R
T
Y
W
Q
E
L
I
D
L
Site 24
T224
Q
E
L
I
D
L
N
T
G
E
S
T
D
I
D
Site 25
S248
K
R
L
D
N
D
I
S
L
E
A
Q
V
G
D
Site 26
S304
G
V
Q
E
E
D
G
S
W
S
A
V
T
L
S
Site 27
T309
D
G
S
W
S
A
V
T
L
S
N
D
H
N
A
Site 28
S332
L
K
L
E
H
P
K
S
E
A
K
S
V
V
K
Site 29
S336
H
P
K
S
E
A
K
S
V
V
K
Q
D
R
L
Site 30
Y381
D
Q
L
N
D
N
E
Y
T
K
F
I
P
P
N
Site 31
Y389
T
K
F
I
P
P
N
Y
H
T
P
P
Y
L
T
Site 32
T391
F
I
P
P
N
Y
H
T
P
P
Y
L
T
A
E
Site 33
Y394
P
N
Y
H
T
P
P
Y
L
T
A
E
P
E
V
Site 34
T402
L
T
A
E
P
E
V
T
Y
H
R
L
R
P
Q
Site 35
Y403
T
A
E
P
E
V
T
Y
H
R
L
R
P
Q
D
Site 36
T454
A
V
G
G
Y
K
V
T
L
G
Q
M
H
G
L
Site 37
T463
G
Q
M
H
G
L
L
T
E
R
R
T
K
M
S
Site 38
T467
G
L
L
T
E
R
R
T
K
M
S
S
V
F
E
Site 39
S470
T
E
R
R
T
K
M
S
S
V
F
E
D
Q
N
Site 40
S471
E
R
R
T
K
M
S
S
V
F
E
D
Q
N
A
Site 41
T494
V
G
N
N
E
F
G
T
V
D
H
E
R
L
S
Site 42
S501
T
V
D
H
E
R
L
S
K
M
L
S
L
P
E
Site 43
S505
E
R
L
S
K
M
L
S
L
P
E
E
L
A
R
Site 44
Y514
P
E
E
L
A
R
M
Y
R
D
D
I
T
I
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation