PhosphoNET

           
Protein Info 
   
Short Name:  ADAM22
Full Name:  Disintegrin and metalloproteinase domain-containing protein 22
Alias:  A disintegrin and metalloproteinase domain 22; ADA22; ADAM 22; ADAM metallopeptidase domain 22; Disintegrin and metalloproteinase domain-containing protein 22: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2: Metalloproteinase-disintegrin ADAM22-3: Disintegrin and metalloproteinase domain-containing protein 22: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2: Metalloproteinase-disintegrin ADAM22-3: Disintegrin and metalloproteinase domain-containing protein 22: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2: Metalloproteinase-disintegrin ADAM22-3: Disintegrin and metalloproteinase domain-containing protein 22: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2: Metalloproteinase-disintegrin ADAM22-3: Disintegrin and metalloproteinase domain-containing protein 22: Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2: Metalloproteinase-disintegrin ADAM22-3; MDC2; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
Type:  Integral membrane protein
Mass (Da):  100433
Number AA:  906
UniProt ID:  Q9P0K1
International Prot ID:  IPI00000779
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016021     Uniprot OncoNet
Molecular Function:  GO:0005178  GO:0004222  GO:0008270 PhosphoSite+ KinaseNET
Biological Process:  GO:0007155  GO:0007417  GO:0007162 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S32CGQAGDASLMELEKR
Site 2Y57IVPLRLIYRSGGEDE
Site 3S59PLRLIYRSGGEDESR
Site 4S65RSGGEDESRHDALDT
Site 5T72SRHDALDTRVRGDLG
Site 6T84DLGGPQLTHVDQASF
Site 7S112VLNHDLLSSEYIERH
Site 8Y115HDLLSSEYIERHIEH
Site 9T126HIEHGGKTVEVKGGE
Site 10Y136VKGGEHCYYQGHIRG
Site 11Y137KGGEHCYYQGHIRGN
Site 12S147HIRGNPDSFVALSTC
Site 13Y162HGLHGMFYDGNHTYL
Site 14T177IEPEENDTTQEDFHF
Site 15T178EPEENDTTQEDFHFH
Site 16Y188DFHFHSVYKSRLFEF
Site 17S190HFHSVYKSRLFEFSL
Site 18S196KSRLFEFSLDDLPSE
Site 19S202FSLDDLPSEFQQVNI
Site 20T210EFQQVNITPSKFILK
Site 21T262HRLSVVHTNTYAKSV
Site 22T264LSVVHTNTYAKSVVN
Site 23S302TDNKFAISENPLITL
Site 24T308ISENPLITLREFMKY
Site 25Y650EEDVDLGYVEDGTPC
Site 26Y760LGITAWGYKNYREQR
Site 27Y774RQLPQGDYVKKPGDG
Site 28S783KKPGDGDSFYSDIPP
Site 29Y785PGDGDSFYSDIPPGV
Site 30S786GDGDSFYSDIPPGVS
Site 31S793SDIPPGVSTNSASSS
Site 32T794DIPPGVSTNSASSSK
Site 33S796PPGVSTNSASSSKKR
Site 34S798GVSTNSASSSKKRSN
Site 35S799VSTNSASSSKKRSNG
Site 36S800STNSASSSKKRSNGL
Site 37S804ASSSKKRSNGLSHSW
Site 38S808KKRSNGLSHSWSERI
Site 39S810RSNGLSHSWSERIPD
Site 40S812NGLSHSWSERIPDTK
Site 41T818WSERIPDTKHISDIC
Site 42S822IPDTKHISDICENGR
Site 43S832CENGRPRSNSWQGNL
Site 44S834NGRPRSNSWQGNLGG
Site 45S855GKRFRPRSNSTETLS
Site 46S857RFRPRSNSTETLSPA
Site 47T858FRPRSNSTETLSPAK
Site 48T860PRSNSTETLSPAKSP
Site 49S862SNSTETLSPAKSPSS
Site 50S866ETLSPAKSPSSSTGS
Site 51S868LSPAKSPSSSTGSIA
Site 52S869SPAKSPSSSTGSIAS
Site 53S870PAKSPSSSTGSIASS
Site 54T871AKSPSSSTGSIASSR
Site 55S873SPSSSTGSIASSRKY
Site 56S876SSTGSIASSRKYPYP
Site 57S877STGSIASSRKYPYPM
Site 58Y880SIASSRKYPYPMPPL
Site 59Y882ASSRKYPYPMPPLPD
Site 60S898DKKVNRQSARLWETS
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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