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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GMIP
Full Name:
GEM-interacting protein
Alias:
Type:
Activator, Rho GTPase activator
Mass (Da):
106683
Number AA:
970
UniProt ID:
Q9P107
International Prot ID:
IPI00292376
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005100
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0034259
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y18
G
P
E
G
R
K
R
Y
S
D
I
F
R
S
L
Site 2
S19
P
E
G
R
K
R
Y
S
D
I
F
R
S
L
D
Site 3
S24
R
Y
S
D
I
F
R
S
L
D
N
L
E
I
S
Site 4
S47
L
A
G
D
P
L
L
S
E
D
P
E
P
D
K
Site 5
T55
E
D
P
E
P
D
K
T
P
T
A
T
V
T
N
Site 6
T59
P
D
K
T
P
T
A
T
V
T
N
E
A
S
C
Site 7
T61
K
T
P
T
A
T
V
T
N
E
A
S
C
W
S
Site 8
S65
A
T
V
T
N
E
A
S
C
W
S
G
P
S
P
Site 9
S71
A
S
C
W
S
G
P
S
P
E
G
P
V
P
L
Site 10
T79
P
E
G
P
V
P
L
T
G
E
E
L
D
L
R
Site 11
Y100
G
V
D
A
A
L
E
Y
A
K
T
W
S
R
Y
Site 12
T103
A
A
L
E
Y
A
K
T
W
S
R
Y
A
K
E
Site 13
Y107
Y
A
K
T
W
S
R
Y
A
K
E
L
L
A
W
Site 14
S120
A
W
T
E
K
R
A
S
Y
E
L
E
F
A
K
Site 15
Y121
W
T
E
K
R
A
S
Y
E
L
E
F
A
K
S
Site 16
S128
Y
E
L
E
F
A
K
S
T
M
K
I
A
E
A
Site 17
Y152
H
M
P
L
Q
Y
I
Y
T
L
F
L
E
H
D
Site 18
T169
L
G
T
L
A
M
E
T
V
A
Q
Q
K
R
D
Site 19
Y177
V
A
Q
Q
K
R
D
Y
Y
Q
P
L
A
A
K
Site 20
Y178
A
Q
Q
K
R
D
Y
Y
Q
P
L
A
A
K
R
Site 21
Y220
L
R
R
A
Q
L
Q
Y
V
Q
R
S
E
D
L
Site 22
S224
Q
L
Q
Y
V
Q
R
S
E
D
L
R
A
R
S
Site 23
S231
S
E
D
L
R
A
R
S
Q
G
S
P
E
D
S
Site 24
S234
L
R
A
R
S
Q
G
S
P
E
D
S
A
P
Q
Site 25
S238
S
Q
G
S
P
E
D
S
A
P
Q
A
S
P
G
Site 26
S243
E
D
S
A
P
Q
A
S
P
G
P
S
K
Q
Q
Site 27
S247
P
Q
A
S
P
G
P
S
K
Q
Q
E
R
R
R
Site 28
S256
Q
Q
E
R
R
R
R
S
R
E
E
A
Q
A
K
Site 29
Y271
A
Q
E
A
E
A
L
Y
Q
A
C
V
R
E
A
Site 30
S294
I
A
K
Q
R
I
V
S
H
V
R
K
L
V
F
Site 31
S313
V
L
R
R
V
T
L
S
L
F
G
L
R
G
A
Site 32
Y345
P
F
E
P
G
Q
R
Y
Q
E
F
V
R
A
L
Site 33
S365
P
P
P
P
P
A
F
S
F
Q
E
F
L
P
S
Site 34
S372
S
F
Q
E
F
L
P
S
L
N
S
S
P
L
D
Site 35
S375
E
F
L
P
S
L
N
S
S
P
L
D
I
R
K
Site 36
S376
F
L
P
S
L
N
S
S
P
L
D
I
R
K
K
Site 37
S385
L
D
I
R
K
K
L
S
G
P
L
P
P
R
L
Site 38
S396
P
P
R
L
D
E
N
S
A
E
P
G
P
W
E
Site 39
T414
T
G
W
R
W
Q
G
T
P
G
P
T
P
G
S
Site 40
T418
W
Q
G
T
P
G
P
T
P
G
S
D
V
D
S
Site 41
S421
T
P
G
P
T
P
G
S
D
V
D
S
V
G
G
Site 42
S425
T
P
G
S
D
V
D
S
V
G
G
G
S
E
S
Site 43
S430
V
D
S
V
G
G
G
S
E
S
R
S
L
D
S
Site 44
S432
S
V
G
G
G
S
E
S
R
S
L
D
S
P
T
Site 45
S434
G
G
G
S
E
S
R
S
L
D
S
P
T
S
S
Site 46
S437
S
E
S
R
S
L
D
S
P
T
S
S
P
G
A
Site 47
T439
S
R
S
L
D
S
P
T
S
S
P
G
A
G
T
Site 48
S440
R
S
L
D
S
P
T
S
S
P
G
A
G
T
R
Site 49
S441
S
L
D
S
P
T
S
S
P
G
A
G
T
R
Q
Site 50
S454
R
Q
L
V
K
A
S
S
T
G
T
E
S
S
D
Site 51
T455
Q
L
V
K
A
S
S
T
G
T
E
S
S
D
D
Site 52
T457
V
K
A
S
S
T
G
T
E
S
S
D
D
F
E
Site 53
S459
A
S
S
T
G
T
E
S
S
D
D
F
E
E
R
Site 54
S460
S
S
T
G
T
E
S
S
D
D
F
E
E
R
D
Site 55
S480
G
L
E
N
G
L
G
S
P
F
G
K
W
T
L
Site 56
T486
G
S
P
F
G
K
W
T
L
S
S
A
A
Q
T
Site 57
S488
P
F
G
K
W
T
L
S
S
A
A
Q
T
H
Q
Site 58
S489
F
G
K
W
T
L
S
S
A
A
Q
T
H
Q
L
Site 59
T493
T
L
S
S
A
A
Q
T
H
Q
L
R
R
L
R
Site 60
T546
H
R
R
L
P
A
R
T
P
L
F
G
V
D
F
Site 61
S589
V
Q
G
I
Y
R
V
S
G
S
R
V
R
V
E
Site 62
S591
G
I
Y
R
V
S
G
S
R
V
R
V
E
R
L
Site 63
S612
G
R
A
L
V
E
L
S
G
N
S
P
H
D
V
Site 64
S615
L
V
E
L
S
G
N
S
P
H
D
V
S
S
V
Site 65
S620
G
N
S
P
H
D
V
S
S
V
L
K
R
F
L
Site 66
S621
N
S
P
H
D
V
S
S
V
L
K
R
F
L
Q
Site 67
T631
K
R
F
L
Q
E
L
T
E
P
V
I
P
F
H
Site 68
T660
D
P
G
D
D
P
G
T
P
S
P
S
P
E
V
Site 69
S662
G
D
D
P
G
T
P
S
P
S
P
E
V
I
R
Site 70
S664
D
P
G
T
P
S
P
S
P
E
V
I
R
S
L
Site 71
S681
L
L
V
Q
L
P
D
S
N
Y
N
T
L
R
H
Site 72
Y683
V
Q
L
P
D
S
N
Y
N
T
L
R
H
L
V
Site 73
T685
L
P
D
S
N
Y
N
T
L
R
H
L
V
A
H
Site 74
S773
T
E
P
P
P
Q
D
S
S
P
A
P
G
P
L
Site 75
S774
E
P
P
P
Q
D
S
S
P
A
P
G
P
L
T
Site 76
T781
S
P
A
P
G
P
L
T
T
S
S
Q
P
P
P
Site 77
S783
A
P
G
P
L
T
T
S
S
Q
P
P
P
P
H
Site 78
S784
P
G
P
L
T
T
S
S
Q
P
P
P
P
H
L
Site 79
S795
P
P
H
L
D
P
D
S
Q
P
P
V
L
A
S
Site 80
S802
S
Q
P
P
V
L
A
S
D
P
G
P
D
P
Q
Site 81
S812
G
P
D
P
Q
H
H
S
T
L
E
Q
H
P
T
Site 82
T813
P
D
P
Q
H
H
S
T
L
E
Q
H
P
T
A
Site 83
T819
S
T
L
E
Q
H
P
T
A
T
P
T
E
I
P
Site 84
T821
L
E
Q
H
P
T
A
T
P
T
E
I
P
T
P
Site 85
T823
Q
H
P
T
A
T
P
T
E
I
P
T
P
Q
S
Site 86
T827
A
T
P
T
E
I
P
T
P
Q
S
D
Q
R
E
Site 87
S830
T
E
I
P
T
P
Q
S
D
Q
R
E
D
V
A
Site 88
T840
R
E
D
V
A
E
D
T
K
D
G
G
G
E
V
Site 89
S849
D
G
G
G
E
V
S
S
Q
G
P
E
D
S
L
Site 90
S855
S
S
Q
G
P
E
D
S
L
L
G
T
Q
S
R
Site 91
T859
P
E
D
S
L
L
G
T
Q
S
R
G
H
F
S
Site 92
S861
D
S
L
L
G
T
Q
S
R
G
H
F
S
R
Q
Site 93
Y872
F
S
R
Q
P
V
K
Y
P
R
G
G
V
R
P
Site 94
T881
R
G
G
V
R
P
V
T
H
Q
L
S
S
L
A
Site 95
T898
A
S
K
L
C
E
E
T
P
I
T
S
V
P
R
Site 96
T901
L
C
E
E
T
P
I
T
S
V
P
R
G
S
L
Site 97
S902
C
E
E
T
P
I
T
S
V
P
R
G
S
L
R
Site 98
S907
I
T
S
V
P
R
G
S
L
R
G
R
G
P
S
Site 99
S914
S
L
R
G
R
G
P
S
P
A
A
A
S
P
E
Site 100
S919
G
P
S
P
A
A
A
S
P
E
G
S
P
L
R
Site 101
S923
A
A
A
S
P
E
G
S
P
L
R
R
T
P
L
Site 102
T928
E
G
S
P
L
R
R
T
P
L
P
K
H
F
E
Site 103
S945
Q
E
T
A
R
L
L
S
K
L
D
S
E
A
V
Site 104
S949
R
L
L
S
K
L
D
S
E
A
V
P
R
A
T
Site 105
T956
S
E
A
V
P
R
A
T
C
C
P
D
V
Q
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation