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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS54
Full Name:
Vacuolar protein sorting-associated protein 54
Alias:
HCC8; hepatocellular carcinoma 8; SLP-8p; Tumor antigen SLP-8p; VPS54L
Type:
Vesicle protein
Mass (Da):
110589
Number AA:
977
UniProt ID:
Q9P1Q0
International Prot ID:
IPI00163718
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
GO:0042147
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
S
S
H
S
S
S
P
V
P
Q
G
Site 2
S7
_
M
A
S
S
H
S
S
S
P
V
P
Q
G
S
Site 3
S8
M
A
S
S
H
S
S
S
P
V
P
Q
G
S
S
Site 4
S14
S
S
P
V
P
Q
G
S
S
S
D
V
F
F
K
Site 5
S16
P
V
P
Q
G
S
S
S
D
V
F
F
K
I
E
Site 6
S27
F
K
I
E
V
D
P
S
K
H
I
R
P
V
P
Site 7
S35
K
H
I
R
P
V
P
S
L
P
D
V
C
P
K
Site 8
S50
E
P
T
G
D
S
H
S
L
Y
V
A
P
S
L
Site 9
Y52
T
G
D
S
H
S
L
Y
V
A
P
S
L
V
T
Site 10
S56
H
S
L
Y
V
A
P
S
L
V
T
D
Q
H
R
Site 11
Y67
D
Q
H
R
W
T
V
Y
H
S
K
V
N
L
P
Site 12
S87
P
R
L
A
K
R
E
S
D
F
F
T
K
T
W
Site 13
T91
K
R
E
S
D
F
F
T
K
T
W
G
L
D
F
Site 14
T93
E
S
D
F
F
T
K
T
W
G
L
D
F
V
D
Site 15
Y108
T
E
V
I
P
S
F
Y
L
P
Q
I
S
K
E
Site 16
Y120
S
K
E
H
F
T
V
Y
Q
Q
E
I
S
Q
R
Site 17
S125
T
V
Y
Q
Q
E
I
S
Q
R
E
K
I
H
E
Site 18
T143
N
I
C
P
P
K
D
T
F
E
R
T
L
L
H
Site 19
T151
F
E
R
T
L
L
H
T
H
D
K
S
R
T
D
Site 20
S155
L
L
H
T
H
D
K
S
R
T
D
L
E
Q
V
Site 21
T157
H
T
H
D
K
S
R
T
D
L
E
Q
V
P
K
Site 22
S181
D
D
S
L
T
F
N
S
V
L
P
W
S
H
F
Site 23
T190
L
P
W
S
H
F
N
T
A
G
G
K
G
N
R
Site 24
S201
K
G
N
R
D
A
A
S
S
K
L
L
Q
E
K
Site 25
S202
G
N
R
D
A
A
S
S
K
L
L
Q
E
K
L
Site 26
Y212
L
Q
E
K
L
S
H
Y
L
D
I
V
E
V
N
Site 27
S228
A
H
Q
I
S
L
R
S
E
A
F
F
H
A
M
Site 28
Y244
S
Q
H
E
L
Q
D
Y
L
R
K
T
S
Q
A
Site 29
T248
L
Q
D
Y
L
R
K
T
S
Q
A
V
K
M
L
Site 30
S249
Q
D
Y
L
R
K
T
S
Q
A
V
K
M
L
R
Site 31
T295
N
K
L
K
L
M
A
T
V
H
Q
T
Q
P
T
Site 32
T302
T
V
H
Q
T
Q
P
T
V
Q
V
L
L
S
T
Site 33
S335
Q
E
L
Q
G
I
H
S
F
R
H
L
G
S
Q
Site 34
S341
H
S
F
R
H
L
G
S
Q
L
C
E
L
E
K
Site 35
S359
K
M
M
I
A
E
F
S
T
Y
S
H
S
D
L
Site 36
T360
M
M
I
A
E
F
S
T
Y
S
H
S
D
L
N
Site 37
Y361
M
I
A
E
F
S
T
Y
S
H
S
D
L
N
R
Site 38
S362
I
A
E
F
S
T
Y
S
H
S
D
L
N
R
P
Site 39
S364
E
F
S
T
Y
S
H
S
D
L
N
R
P
L
E
Site 40
T429
S
Q
T
E
E
I
D
T
D
V
V
V
K
L
A
Site 41
S503
K
N
A
A
K
D
N
S
L
D
T
E
V
A
Y
Site 42
T506
A
K
D
N
S
L
D
T
E
V
A
Y
L
I
H
Site 43
S519
I
H
E
G
M
F
I
S
D
A
F
G
E
G
E
Site 44
T534
L
T
P
I
A
V
D
T
T
S
Q
R
N
A
S
Site 45
S536
P
I
A
V
D
T
T
S
Q
R
N
A
S
P
N
Site 46
S541
T
T
S
Q
R
N
A
S
P
N
S
E
P
C
S
Site 47
S544
Q
R
N
A
S
P
N
S
E
P
C
S
S
D
S
Site 48
S548
S
P
N
S
E
P
C
S
S
D
S
V
S
E
P
Site 49
S549
P
N
S
E
P
C
S
S
D
S
V
S
E
P
E
Site 50
S551
S
E
P
C
S
S
D
S
V
S
E
P
E
C
T
Site 51
S553
P
C
S
S
D
S
V
S
E
P
E
C
T
T
D
Site 52
T558
S
V
S
E
P
E
C
T
T
D
S
S
S
S
K
Site 53
T559
V
S
E
P
E
C
T
T
D
S
S
S
S
K
E
Site 54
S561
E
P
E
C
T
T
D
S
S
S
S
K
E
H
T
Site 55
S562
P
E
C
T
T
D
S
S
S
S
K
E
H
T
S
Site 56
S563
E
C
T
T
D
S
S
S
S
K
E
H
T
S
S
Site 57
S564
C
T
T
D
S
S
S
S
K
E
H
T
S
S
S
Site 58
T568
S
S
S
S
K
E
H
T
S
S
S
A
I
P
G
Site 59
S569
S
S
S
K
E
H
T
S
S
S
A
I
P
G
G
Site 60
S570
S
S
K
E
H
T
S
S
S
A
I
P
G
G
V
Site 61
S571
S
K
E
H
T
S
S
S
A
I
P
G
G
V
D
Site 62
S582
G
G
V
D
I
M
V
S
E
D
M
K
L
T
D
Site 63
T588
V
S
E
D
M
K
L
T
D
S
E
L
G
K
L
Site 64
S590
E
D
M
K
L
T
D
S
E
L
G
K
L
A
N
Site 65
Y604
N
N
I
Q
E
L
L
Y
S
A
S
D
I
C
H
Site 66
S605
N
I
Q
E
L
L
Y
S
A
S
D
I
C
H
D
Site 67
S607
Q
E
L
L
Y
S
A
S
D
I
C
H
D
R
A
Site 68
S657
E
Q
I
C
G
R
K
S
T
S
L
L
G
A
L
Site 69
T658
Q
I
C
G
R
K
S
T
S
L
L
G
A
L
Q
Site 70
T681
R
F
H
E
E
R
K
T
K
L
S
L
L
L
D
Site 71
S684
E
E
R
K
T
K
L
S
L
L
L
D
N
E
R
Site 72
S707
E
F
Q
D
L
V
D
S
L
S
D
G
K
I
A
Site 73
S709
Q
D
L
V
D
S
L
S
D
G
K
I
A
L
P
Site 74
S720
I
A
L
P
E
K
K
S
G
A
T
E
E
R
K
Site 75
S774
T
D
M
L
T
R
L
S
D
L
L
K
Y
F
N
Site 76
Y779
R
L
S
D
L
L
K
Y
F
N
S
R
S
C
Q
Site 77
Y850
F
D
H
I
T
K
D
Y
H
D
H
I
A
E
I
Site 78
S874
S
L
F
D
K
L
L
S
K
Y
E
V
K
A
P
Site 79
Y876
F
D
K
L
L
S
K
Y
E
V
K
A
P
V
P
Site 80
S920
L
F
L
R
I
N
A
S
Y
K
L
H
L
K
K
Site 81
Y921
F
L
R
I
N
A
S
Y
K
L
H
L
K
K
Q
Site 82
S930
L
H
L
K
K
Q
L
S
H
L
N
V
I
N
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation