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Updated November 2019
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Protein Info
Short Name:
KIAA1543
Full Name:
Calmodulin-regulated spectrin-associated protein 3
Alias:
K1543
Type:
Mass (Da):
134750
Number AA:
1249
UniProt ID:
Q9P1Y5
International Prot ID:
IPI00176702
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
G
P
G
P
L
R
R
T
F
L
V
P
E
I
K
Site 2
S23
F
L
V
P
E
I
K
S
L
D
Q
Y
D
F
S
Site 3
Y27
E
I
K
S
L
D
Q
Y
D
F
S
R
A
K
A
Site 4
Y61
P
E
L
W
E
P
F
Y
T
D
Q
Y
A
Q
E
Site 5
Y65
E
P
F
Y
T
D
Q
Y
A
Q
E
H
V
K
P
Site 6
T97
Q
A
L
P
Q
L
E
T
P
P
N
P
S
A
L
Site 7
T113
A
L
L
A
R
R
G
T
V
P
A
L
P
E
R
Site 8
T175
K
L
L
F
W
V
D
T
T
V
R
R
L
Q
E
Site 9
T176
L
L
F
W
V
D
T
T
V
R
R
L
Q
E
K
Site 10
T184
V
R
R
L
Q
E
K
T
E
Q
E
A
A
Q
R
Site 11
S193
Q
E
A
A
Q
R
A
S
P
A
A
P
A
D
G
Site 12
S207
G
A
A
P
A
Q
P
S
I
R
Y
R
K
D
R
Site 13
S334
L
P
D
G
H
A
A
S
P
R
G
T
E
A
S
Site 14
T338
H
A
A
S
P
R
G
T
E
A
S
P
P
Q
N
Site 15
S341
S
P
R
G
T
E
A
S
P
P
Q
N
N
S
G
Site 16
S347
A
S
P
P
Q
N
N
S
G
S
S
S
P
V
F
Site 17
S349
P
P
Q
N
N
S
G
S
S
S
P
V
F
T
F
Site 18
S350
P
Q
N
N
S
G
S
S
S
P
V
F
T
F
R
Site 19
S351
Q
N
N
S
G
S
S
S
P
V
F
T
F
R
H
Site 20
T355
G
S
S
S
P
V
F
T
F
R
H
P
L
L
S
Site 21
S362
T
F
R
H
P
L
L
S
S
G
G
P
Q
S
P
Site 22
S363
F
R
H
P
L
L
S
S
G
G
P
Q
S
P
L
Site 23
S368
L
S
S
G
G
P
Q
S
P
L
R
G
S
T
G
Site 24
S373
P
Q
S
P
L
R
G
S
T
G
S
L
K
S
S
Site 25
T374
Q
S
P
L
R
G
S
T
G
S
L
K
S
S
P
Site 26
S376
P
L
R
G
S
T
G
S
L
K
S
S
P
S
M
Site 27
S379
G
S
T
G
S
L
K
S
S
P
S
M
S
H
M
Site 28
S380
S
T
G
S
L
K
S
S
P
S
M
S
H
M
E
Site 29
S382
G
S
L
K
S
S
P
S
M
S
H
M
E
A
L
Site 30
S384
L
K
S
S
P
S
M
S
H
M
E
A
L
G
K
Site 31
S398
K
A
W
N
R
Q
L
S
R
P
L
S
Q
A
V
Site 32
S402
R
Q
L
S
R
P
L
S
Q
A
V
S
F
S
T
Site 33
T409
S
Q
A
V
S
F
S
T
P
F
G
L
D
S
D
Site 34
S429
G
D
P
V
L
L
R
S
V
S
S
D
S
L
G
Site 35
S431
P
V
L
L
R
S
V
S
S
D
S
L
G
P
P
Site 36
S432
V
L
L
R
S
V
S
S
D
S
L
G
P
P
R
Site 37
S434
L
R
S
V
S
S
D
S
L
G
P
P
R
P
A
Site 38
T445
P
R
P
A
P
A
R
T
P
T
Q
P
P
P
E
Site 39
T447
P
A
P
A
R
T
P
T
Q
P
P
P
E
P
G
Site 40
T458
P
E
P
G
D
L
P
T
I
E
E
A
L
Q
I
Site 41
S482
P
D
G
A
A
D
G
S
F
Y
L
H
S
P
E
Site 42
Y484
G
A
A
D
G
S
F
Y
L
H
S
P
E
G
P
Site 43
S487
D
G
S
F
Y
L
H
S
P
E
G
P
S
K
P
Site 44
S495
P
E
G
P
S
K
P
S
L
A
S
P
Y
L
P
Site 45
S498
P
S
K
P
S
L
A
S
P
Y
L
P
E
G
T
Site 46
Y500
K
P
S
L
A
S
P
Y
L
P
E
G
T
S
K
Site 47
T505
S
P
Y
L
P
E
G
T
S
K
P
L
S
D
R
Site 48
S506
P
Y
L
P
E
G
T
S
K
P
L
S
D
R
P
Site 49
S510
E
G
T
S
K
P
L
S
D
R
P
T
K
A
P
Site 50
T514
K
P
L
S
D
R
P
T
K
A
P
V
Y
M
P
Site 51
Y519
R
P
T
K
A
P
V
Y
M
P
H
P
E
T
P
Site 52
T525
V
Y
M
P
H
P
E
T
P
S
K
P
S
P
C
Site 53
S527
M
P
H
P
E
T
P
S
K
P
S
P
C
L
V
Site 54
S530
P
E
T
P
S
K
P
S
P
C
L
V
G
E
A
Site 55
S538
P
C
L
V
G
E
A
S
K
P
P
A
P
S
E
Site 56
S544
A
S
K
P
P
A
P
S
E
G
S
P
K
A
V
Site 57
S547
P
P
A
P
S
E
G
S
P
K
A
V
A
S
S
Site 58
S553
G
S
P
K
A
V
A
S
S
P
A
A
T
N
S
Site 59
S554
S
P
K
A
V
A
S
S
P
A
A
T
N
S
E
Site 60
T558
V
A
S
S
P
A
A
T
N
S
E
V
K
M
T
Site 61
S560
S
S
P
A
A
T
N
S
E
V
K
M
T
S
F
Site 62
S566
N
S
E
V
K
M
T
S
F
A
E
R
K
K
Q
Site 63
S585
E
A
E
A
G
A
G
S
P
T
S
T
P
A
P
Site 64
T587
E
A
G
A
G
S
P
T
S
T
P
A
P
P
E
Site 65
S588
A
G
A
G
S
P
T
S
T
P
A
P
P
E
A
Site 66
T589
G
A
G
S
P
T
S
T
P
A
P
P
E
A
L
Site 67
S597
P
A
P
P
E
A
L
S
S
E
M
S
E
L
S
Site 68
S598
A
P
P
E
A
L
S
S
E
M
S
E
L
S
A
Site 69
S601
E
A
L
S
S
E
M
S
E
L
S
A
R
L
E
Site 70
S604
S
S
E
M
S
E
L
S
A
R
L
E
E
K
R
Site 71
S646
Q
V
Q
P
R
E
A
S
G
E
A
E
A
E
A
Site 72
S658
A
E
A
E
E
A
D
S
G
P
V
P
G
G
E
Site 73
T676
G
E
G
Q
G
E
P
T
S
R
P
K
A
V
T
Site 74
S677
E
G
Q
G
E
P
T
S
R
P
K
A
V
T
F
Site 75
T683
T
S
R
P
K
A
V
T
F
S
P
D
L
G
P
Site 76
S685
R
P
K
A
V
T
F
S
P
D
L
G
P
V
P
Site 77
Y699
P
H
E
G
L
G
E
Y
N
R
A
V
S
K
L
Site 78
S704
G
E
Y
N
R
A
V
S
K
L
S
A
A
L
S
Site 79
S707
N
R
A
V
S
K
L
S
A
A
L
S
S
L
Q
Site 80
S711
S
K
L
S
A
A
L
S
S
L
Q
R
D
M
Q
Site 81
S712
K
L
S
A
A
L
S
S
L
Q
R
D
M
Q
R
Site 82
T721
Q
R
D
M
Q
R
L
T
D
Q
Q
Q
R
L
L
Site 83
S736
A
P
P
E
A
P
G
S
A
P
P
P
A
A
W
Site 84
S756
T
T
G
P
K
A
A
S
P
S
P
A
R
R
V
Site 85
S758
G
P
K
A
A
S
P
S
P
A
R
R
V
P
A
Site 86
T766
P
A
R
R
V
P
A
T
R
R
S
P
G
P
G
Site 87
S769
R
V
P
A
T
R
R
S
P
G
P
G
P
S
Q
Site 88
S775
R
S
P
G
P
G
P
S
Q
S
P
R
S
P
K
Site 89
S777
P
G
P
G
P
S
Q
S
P
R
S
P
K
H
T
Site 90
S780
G
P
S
Q
S
P
R
S
P
K
H
T
R
P
A
Site 91
T784
S
P
R
S
P
K
H
T
R
P
A
E
L
R
L
Site 92
T795
E
L
R
L
A
P
L
T
R
V
L
T
P
P
H
Site 93
T799
A
P
L
T
R
V
L
T
P
P
H
D
V
D
S
Site 94
S806
T
P
P
H
D
V
D
S
L
P
H
L
R
K
F
Site 95
S814
L
P
H
L
R
K
F
S
P
S
Q
V
P
V
Q
Site 96
S816
H
L
R
K
F
S
P
S
Q
V
P
V
Q
T
R
Site 97
T832
S
I
L
L
A
E
E
T
P
P
E
E
P
A
A
Site 98
S863
A
E
D
E
G
D
G
S
P
A
G
A
E
D
S
Site 99
S870
S
P
A
G
A
E
D
S
L
E
E
E
A
S
S
Site 100
S876
D
S
L
E
E
E
A
S
S
E
G
E
P
R
V
Site 101
S877
S
L
E
E
E
A
S
S
E
G
E
P
R
V
G
Site 102
S905
E
M
A
Q
K
R
A
S
L
L
E
R
Q
Q
R
Site 103
T978
G
P
R
K
G
D
F
T
R
Q
E
Y
E
R
R
Site 104
Y982
G
D
F
T
R
Q
E
Y
E
R
R
A
Q
L
K
Site 105
S1005
L
R
P
R
A
A
G
S
G
G
P
G
R
G
G
Site 106
T1016
G
R
G
G
R
R
A
T
R
P
R
S
G
C
C
Site 107
S1020
R
R
A
T
R
P
R
S
G
C
C
D
D
S
A
Site 108
S1026
R
S
G
C
C
D
D
S
A
L
A
R
S
P
A
Site 109
S1031
D
D
S
A
L
A
R
S
P
A
R
G
L
L
G
Site 110
S1039
P
A
R
G
L
L
G
S
R
L
S
K
I
Y
S
Site 111
S1042
G
L
L
G
S
R
L
S
K
I
Y
S
Q
S
T
Site 112
Y1045
G
S
R
L
S
K
I
Y
S
Q
S
T
L
S
L
Site 113
S1046
S
R
L
S
K
I
Y
S
Q
S
T
L
S
L
S
Site 114
S1048
L
S
K
I
Y
S
Q
S
T
L
S
L
S
T
V
Site 115
T1049
S
K
I
Y
S
Q
S
T
L
S
L
S
T
V
A
Site 116
S1051
I
Y
S
Q
S
T
L
S
L
S
T
V
A
N
E
Site 117
S1053
S
Q
S
T
L
S
L
S
T
V
A
N
E
A
H
Site 118
T1069
N
L
G
V
K
R
P
T
S
R
A
P
S
P
S
Site 119
S1070
L
G
V
K
R
P
T
S
R
A
P
S
P
S
G
Site 120
S1074
R
P
T
S
R
A
P
S
P
S
G
L
M
S
P
Site 121
S1076
T
S
R
A
P
S
P
S
G
L
M
S
P
S
R
Site 122
S1080
P
S
P
S
G
L
M
S
P
S
R
L
P
G
S
Site 123
S1082
P
S
G
L
M
S
P
S
R
L
P
G
S
R
E
Site 124
S1087
S
P
S
R
L
P
G
S
R
E
R
D
W
E
N
Site 125
S1096
E
R
D
W
E
N
G
S
N
A
S
S
P
A
S
Site 126
S1100
E
N
G
S
N
A
S
S
P
A
S
V
P
E
Y
Site 127
S1103
S
N
A
S
S
P
A
S
V
P
E
Y
T
G
P
Site 128
Y1107
S
P
A
S
V
P
E
Y
T
G
P
R
L
Y
K
Site 129
Y1113
E
Y
T
G
P
R
L
Y
K
E
P
S
A
K
S
Site 130
S1117
P
R
L
Y
K
E
P
S
A
K
S
N
K
F
I
Site 131
S1120
Y
K
E
P
S
A
K
S
N
K
F
I
I
H
N
Site 132
S1153
I
L
E
E
I
E
K
S
K
A
N
H
F
L
I
Site 133
Y1173
S
C
Q
F
R
A
L
Y
T
L
S
G
E
T
E
Site 134
S1176
F
R
A
L
Y
T
L
S
G
E
T
E
E
L
S
Site 135
S1183
S
G
E
T
E
E
L
S
R
L
A
G
Y
G
P
Site 136
Y1188
E
L
S
R
L
A
G
Y
G
P
R
T
V
T
P
Site 137
Y1202
P
A
M
V
E
G
I
Y
K
Y
N
S
D
R
K
Site 138
Y1204
M
V
E
G
I
Y
K
Y
N
S
D
R
K
R
F
Site 139
S1206
E
G
I
Y
K
Y
N
S
D
R
K
R
F
T
Q
Site 140
T1212
N
S
D
R
K
R
F
T
Q
I
P
A
K
T
M
Site 141
T1240
W
Q
G
K
K
P
T
T
P
K
K
G
G
G
T
Site 142
T1247
T
P
K
K
G
G
G
T
P
K
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation