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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZBTB4
Full Name:
Zinc finger and BTB domain-containing protein 4
Alias:
KAISO-L1; KAISO-like zinc finger 1; KIAA1538; zinc finger and BTB domain containing 4; zinc finger and BTB domain-containing 4
Type:
DNA binding protein
Mass (Da):
105110
Number AA:
1013
UniProt ID:
Q9P1Z0
International Prot ID:
IPI00001835
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
A
E
V
T
D
P
S
H
A
P
A
V
L
R
Site 2
T39
V
T
L
I
A
G
D
T
K
F
P
A
H
R
S
Site 3
S46
T
K
F
P
A
H
R
S
V
L
A
A
S
S
P
Site 4
T71
P
L
P
L
P
P
A
T
G
G
A
A
P
N
P
Site 5
T80
G
A
A
P
N
P
A
T
T
T
A
A
S
S
S
Site 6
T81
A
A
P
N
P
A
T
T
T
A
A
S
S
S
S
Site 7
T82
A
P
N
P
A
T
T
T
A
A
S
S
S
S
S
Site 8
S85
P
A
T
T
T
A
A
S
S
S
S
S
S
S
S
Site 9
S86
A
T
T
T
A
A
S
S
S
S
S
S
S
S
S
Site 10
S87
T
T
T
A
A
S
S
S
S
S
S
S
S
S
S
Site 11
S88
T
T
A
A
S
S
S
S
S
S
S
S
S
S
S
Site 12
S89
T
A
A
S
S
S
S
S
S
S
S
S
S
S
S
Site 13
S90
A
A
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 14
S91
A
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 15
S92
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 16
S94
S
S
S
S
S
S
S
S
S
S
S
S
S
S
A
Site 17
S95
S
S
S
S
S
S
S
S
S
S
S
S
S
A
S
Site 18
S96
S
S
S
S
S
S
S
S
S
S
S
S
A
S
S
Site 19
S97
S
S
S
S
S
S
S
S
S
S
S
A
S
S
S
Site 20
S98
S
S
S
S
S
S
S
S
S
S
A
S
S
S
S
Site 21
S99
S
S
S
S
S
S
S
S
S
A
S
S
S
S
S
Site 22
S100
S
S
S
S
S
S
S
S
A
S
S
S
S
S
S
Site 23
S102
S
S
S
S
S
S
A
S
S
S
S
S
S
S
S
Site 24
S103
S
S
S
S
S
A
S
S
S
S
S
S
S
S
S
Site 25
S104
S
S
S
S
A
S
S
S
S
S
S
S
S
S
S
Site 26
S105
S
S
S
A
S
S
S
S
S
S
S
S
S
S
P
Site 27
S106
S
S
A
S
S
S
S
S
S
S
S
S
S
P
P
Site 28
S107
S
A
S
S
S
S
S
S
S
S
S
S
P
P
P
Site 29
S108
A
S
S
S
S
S
S
S
S
S
S
P
P
P
A
Site 30
S109
S
S
S
S
S
S
S
S
S
S
P
P
P
A
S
Site 31
S110
S
S
S
S
S
S
S
S
S
P
P
P
A
S
P
Site 32
S111
S
S
S
S
S
S
S
S
P
P
P
A
S
P
P
Site 33
S116
S
S
S
P
P
P
A
S
P
P
A
S
S
P
P
Site 34
S120
P
P
A
S
P
P
A
S
S
P
P
R
V
L
E
Site 35
S121
P
A
S
P
P
A
S
S
P
P
R
V
L
E
L
Site 36
S173
L
G
R
R
L
G
I
S
R
L
Q
G
L
G
E
Site 37
T189
G
D
A
W
V
P
P
T
P
A
P
M
A
T
S
Site 38
S196
T
P
A
P
M
A
T
S
Q
P
E
E
D
S
F
Site 39
S202
T
S
Q
P
E
E
D
S
F
G
P
G
P
R
P
Site 40
S228
Q
A
P
D
L
Q
C
S
L
P
R
R
P
L
P
Site 41
T251
I
H
P
K
R
L
Q
T
H
E
A
Q
C
R
R
Site 42
S261
A
Q
C
R
R
G
A
S
T
R
G
S
T
G
L
Site 43
T262
Q
C
R
R
G
A
S
T
R
G
S
T
G
L
G
Site 44
S265
R
G
A
S
T
R
G
S
T
G
L
G
A
G
G
Site 45
T266
G
A
S
T
R
G
S
T
G
L
G
A
G
G
A
Site 46
S322
E
R
S
Y
V
T
L
S
S
L
K
R
H
S
N
Site 47
S323
R
S
Y
V
T
L
S
S
L
K
R
H
S
N
V
Site 48
S328
L
S
S
L
K
R
H
S
N
V
H
S
W
R
R
Site 49
Y341
R
R
K
Y
P
C
R
Y
C
E
K
V
F
A
L
Site 50
T360
T
K
H
E
V
W
H
T
G
E
R
R
Y
Q
C
Site 51
S391
Q
R
A
F
H
G
I
S
P
G
L
L
A
S
E
Site 52
S397
I
S
P
G
L
L
A
S
E
K
T
P
N
G
G
Site 53
T400
G
L
L
A
S
E
K
T
P
N
G
G
Y
K
P
Site 54
Y415
K
L
N
T
L
K
L
Y
R
L
L
P
M
R
A
Site 55
Y427
M
R
A
A
K
R
P
Y
K
T
Y
S
Q
G
A
Site 56
Y430
A
K
R
P
Y
K
T
Y
S
Q
G
A
P
E
A
Site 57
S431
K
R
P
Y
K
T
Y
S
Q
G
A
P
E
A
P
Site 58
S440
G
A
P
E
A
P
L
S
P
T
L
N
T
P
A
Site 59
S454
A
P
V
A
M
P
A
S
P
P
P
G
P
P
P
Site 60
S470
P
E
P
G
P
P
P
S
V
I
T
F
A
H
P
Site 61
T473
G
P
P
P
S
V
I
T
F
A
H
P
A
P
S
Site 62
S487
S
V
I
V
H
G
G
S
S
S
G
G
G
G
S
Site 63
S488
V
I
V
H
G
G
S
S
S
G
G
G
G
S
G
Site 64
S489
I
V
H
G
G
S
S
S
G
G
G
G
S
G
T
Site 65
S494
S
S
S
G
G
G
G
S
G
T
A
S
T
G
G
Site 66
T496
S
G
G
G
G
S
G
T
A
S
T
G
G
S
Q
Site 67
S498
G
G
G
S
G
T
A
S
T
G
G
S
Q
A
A
Site 68
Y510
Q
A
A
S
V
I
T
Y
T
A
P
P
R
P
P
Site 69
T511
A
A
S
V
I
T
Y
T
A
P
P
R
P
P
K
Site 70
Y522
R
P
P
K
K
R
E
Y
P
P
P
P
P
E
P
Site 71
T532
P
P
P
E
P
A
A
T
P
T
S
P
A
T
A
Site 72
S535
E
P
A
A
T
P
T
S
P
A
T
A
V
S
P
Site 73
T569
P
R
A
G
R
T
L
T
Y
T
A
K
P
V
G
Site 74
T586
G
G
G
G
G
P
P
T
G
A
G
R
G
P
S
Site 75
S593
T
G
A
G
R
G
P
S
Q
L
Q
A
P
P
P
Site 76
T605
P
P
P
L
C
Q
I
T
V
R
I
G
E
E
A
Site 77
S619
A
I
V
K
R
R
I
S
E
T
D
L
R
P
G
Site 78
T621
V
K
R
R
I
S
E
T
D
L
R
P
G
E
L
Site 79
S629
D
L
R
P
G
E
L
S
G
E
E
M
E
E
S
Site 80
S636
S
G
E
E
M
E
E
S
E
E
D
E
E
E
E
Site 81
Y667
E
D
Q
L
W
R
P
Y
Y
S
Y
K
P
K
R
Site 82
Y668
D
Q
L
W
R
P
Y
Y
S
Y
K
P
K
R
K
Site 83
Y670
L
W
R
P
Y
Y
S
Y
K
P
K
R
K
A
G
Site 84
S687
G
G
A
S
V
G
G
S
G
L
P
R
G
R
R
Site 85
S706
R
Q
K
L
E
R
R
S
W
E
E
T
P
A
A
Site 86
T710
E
R
R
S
W
E
E
T
P
A
A
E
S
P
A
Site 87
S715
E
E
T
P
A
A
E
S
P
A
G
R
A
R
T
Site 88
T722
S
P
A
G
R
A
R
T
E
R
R
H
R
C
G
Site 89
T734
R
C
G
D
C
A
Q
T
F
T
T
L
R
K
L
Site 90
T737
D
C
A
Q
T
F
T
T
L
R
K
L
R
K
H
Site 91
S752
Q
E
A
H
G
G
G
S
H
S
S
R
A
G
R
Site 92
S754
A
H
G
G
G
S
H
S
S
R
A
G
R
R
P
Site 93
S755
H
G
G
G
S
H
S
S
R
A
G
R
R
P
S
Site 94
S762
S
R
A
G
R
R
P
S
T
R
F
T
C
P
H
Site 95
T763
R
A
G
R
R
P
S
T
R
F
T
C
P
H
C
Site 96
T766
R
R
P
S
T
R
F
T
C
P
H
C
A
K
V
Site 97
T776
H
C
A
K
V
C
K
T
A
A
A
L
S
R
H
Site 98
S781
C
K
T
A
A
A
L
S
R
H
G
Q
R
H
A
Site 99
T795
A
A
E
R
P
G
G
T
P
T
P
V
I
A
Y
Site 100
T797
E
R
P
G
G
T
P
T
P
V
I
A
Y
S
K
Site 101
S803
P
T
P
V
I
A
Y
S
K
G
S
A
G
T
R
Site 102
S825
A
P
Q
E
M
Q
V
S
S
S
S
G
E
A
G
Site 103
S826
P
Q
E
M
Q
V
S
S
S
S
G
E
A
G
G
Site 104
S828
E
M
Q
V
S
S
S
S
G
E
A
G
G
G
S
Site 105
S835
S
G
E
A
G
G
G
S
T
A
A
E
E
A
S
Site 106
S842
S
T
A
A
E
E
A
S
E
T
A
S
L
Q
D
Site 107
T844
A
A
E
E
A
S
E
T
A
S
L
Q
D
P
I
Site 108
S846
E
E
A
S
E
T
A
S
L
Q
D
P
I
I
S
Site 109
Y869
A
S
G
G
S
Y
V
Y
P
P
V
Q
E
F
P
Site 110
S893
P
G
G
G
R
G
K
S
G
S
E
G
P
V
G
Site 111
S895
G
G
R
G
K
S
G
S
E
G
P
V
G
A
G
Site 112
T916
G
I
G
A
A
K
V
T
F
Y
P
E
P
Y
P
Site 113
Y922
V
T
F
Y
P
E
P
Y
P
L
V
Y
G
P
Q
Site 114
Y934
G
P
Q
L
L
A
A
Y
P
Y
N
F
S
N
L
Site 115
T983
A
A
P
P
A
P
P
T
P
P
P
P
T
L
P
Site 116
T988
P
P
T
P
P
P
P
T
L
P
P
P
I
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation