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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HCN3
Full Name:
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Alias:
Hyperpolarization activated cyclic nucleotide-gated potassium channel 3; KIAA1535
Type:
Channel, cation
Mass (Da):
86032
Number AA:
774
UniProt ID:
Q9P1Z3
International Prot ID:
IPI00163724
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0030552
GO:0030955
GO:0005272
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
Q
R
P
A
A
G
A
S
E
G
A
T
P
G
L
Site 2
S34
P
P
P
A
T
A
A
S
G
P
I
P
K
S
G
Site 3
S40
A
S
G
P
I
P
K
S
G
P
E
P
K
R
R
Site 4
T51
P
K
R
R
H
L
G
T
L
L
Q
P
T
V
N
Site 5
S61
Q
P
T
V
N
K
F
S
L
R
V
F
G
S
H
Site 6
S80
I
E
Q
E
R
V
K
S
A
G
A
W
I
I
H
Site 7
Y168
P
R
A
I
R
T
R
Y
L
R
T
W
F
L
V
Site 8
Y298
N
H
S
W
G
R
Q
Y
S
H
A
L
F
K
A
Site 9
S352
H
A
T
A
L
I
Q
S
L
D
S
S
R
R
Q
Site 10
S355
A
L
I
Q
S
L
D
S
S
R
R
Q
Y
Q
E
Site 11
S356
L
I
Q
S
L
D
S
S
R
R
Q
Y
Q
E
K
Site 12
Y360
L
D
S
S
R
R
Q
Y
Q
E
K
Y
K
Q
V
Site 13
Y364
R
R
Q
Y
Q
E
K
Y
K
Q
V
E
Q
Y
M
Site 14
Y370
K
Y
K
Q
V
E
Q
Y
M
S
F
H
K
L
P
Site 15
S372
K
Q
V
E
Q
Y
M
S
F
H
K
L
P
A
D
Site 16
Y387
T
R
Q
R
I
H
E
Y
Y
E
H
R
Y
Q
G
Site 17
Y388
R
Q
R
I
H
E
Y
Y
E
H
R
Y
Q
G
K
Site 18
S401
G
K
M
F
D
E
E
S
I
L
G
E
L
S
E
Site 19
S407
E
S
I
L
G
E
L
S
E
P
L
R
E
E
I
Site 20
T418
R
E
E
I
I
N
F
T
C
R
G
L
V
A
H
Site 21
T438
H
A
D
P
S
F
V
T
A
V
L
T
K
L
R
Site 22
T442
S
F
V
T
A
V
L
T
K
L
R
F
E
V
F
Site 23
S460
D
L
V
V
R
E
G
S
V
G
R
K
M
Y
F
Site 24
T483
L
A
R
G
A
R
D
T
R
L
T
D
G
S
Y
Site 25
T486
G
A
R
D
T
R
L
T
D
G
S
Y
F
G
E
Site 26
S489
D
T
R
L
T
D
G
S
Y
F
G
E
I
C
L
Site 27
Y490
T
R
L
T
D
G
S
Y
F
G
E
I
C
L
L
Site 28
T498
F
G
E
I
C
L
L
T
R
G
R
R
T
A
S
Site 29
T503
L
L
T
R
G
R
R
T
A
S
V
R
A
D
T
Site 30
S505
T
R
G
R
R
T
A
S
V
R
A
D
T
Y
C
Site 31
T510
T
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
Site 32
Y511
A
S
V
R
A
D
T
Y
C
R
L
Y
S
L
S
Site 33
Y515
A
D
T
Y
C
R
L
Y
S
L
S
V
D
H
F
Site 34
S552
L
R
I
G
K
K
N
S
I
L
Q
R
K
R
S
Site 35
S559
S
I
L
Q
R
K
R
S
E
P
S
P
G
S
S
Site 36
S562
Q
R
K
R
S
E
P
S
P
G
S
S
G
G
I
Site 37
S565
R
S
E
P
S
P
G
S
S
G
G
I
M
E
Q
Site 38
S566
S
E
P
S
P
G
S
S
G
G
I
M
E
Q
H
Site 39
S591
G
V
R
G
R
A
P
S
T
G
A
Q
L
S
G
Site 40
T592
V
R
G
R
A
P
S
T
G
A
Q
L
S
G
K
Site 41
S597
P
S
T
G
A
Q
L
S
G
K
P
V
L
W
E
Site 42
S634
Q
R
G
P
L
P
L
S
P
D
S
P
A
T
L
Site 43
S637
P
L
P
L
S
P
D
S
P
A
T
L
L
A
R
Site 44
T640
L
S
P
D
S
P
A
T
L
L
A
R
S
A
W
Site 45
S645
P
A
T
L
L
A
R
S
A
W
R
S
A
G
S
Site 46
S649
L
A
R
S
A
W
R
S
A
G
S
P
A
S
P
Site 47
S652
S
A
W
R
S
A
G
S
P
A
S
P
L
V
P
Site 48
S655
R
S
A
G
S
P
A
S
P
L
V
P
V
R
A
Site 49
S667
V
R
A
G
P
W
A
S
T
S
R
L
P
A
P
Site 50
S669
A
G
P
W
A
S
T
S
R
L
P
A
P
P
A
Site 51
T678
L
P
A
P
P
A
R
T
L
H
A
S
L
S
R
Site 52
S682
P
A
R
T
L
H
A
S
L
S
R
A
G
R
S
Site 53
S684
R
T
L
H
A
S
L
S
R
A
G
R
S
Q
V
Site 54
S689
S
L
S
R
A
G
R
S
Q
V
S
L
L
G
P
Site 55
S692
R
A
G
R
S
Q
V
S
L
L
G
P
P
P
G
Site 56
S713
G
P
R
G
R
P
L
S
A
S
Q
P
S
L
P
Site 57
S715
R
G
R
P
L
S
A
S
Q
P
S
L
P
Q
R
Site 58
S718
P
L
S
A
S
Q
P
S
L
P
Q
R
A
T
G
Site 59
T724
P
S
L
P
Q
R
A
T
G
D
G
S
P
G
R
Site 60
S728
Q
R
A
T
G
D
G
S
P
G
R
K
G
S
G
Site 61
S734
G
S
P
G
R
K
G
S
G
S
E
R
L
P
P
Site 62
S736
P
G
R
K
G
S
G
S
E
R
L
P
P
S
G
Site 63
S742
G
S
E
R
L
P
P
S
G
L
L
A
K
P
P
Site 64
T751
L
L
A
K
P
P
R
T
A
Q
P
P
R
P
P
Site 65
T764
P
P
V
P
E
P
A
T
P
R
G
L
Q
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation