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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WHRN
Full Name:
Whirlin
Alias:
Autosomal recessive deafness type 31 protein; DFNB31; KIAA1526
Type:
Mass (Da):
96558
Number AA:
907
UniProt ID:
Q9P202
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0030426
GO:0032420
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0060122
GO:0050896
GO:0001895
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
N
A
P
L
D
G
L
S
V
S
S
S
S
T
G
Site 2
S11
P
L
D
G
L
S
V
S
S
S
S
T
G
S
L
Site 3
S13
D
G
L
S
V
S
S
S
S
T
G
S
L
G
S
Site 4
S14
G
L
S
V
S
S
S
S
T
G
S
L
G
S
A
Site 5
S20
S
S
T
G
S
L
G
S
A
A
G
A
G
G
G
Site 6
T47
R
Q
L
H
Q
A
L
T
A
L
L
S
E
A
E
Site 7
S51
Q
A
L
T
A
L
L
S
E
A
E
R
E
Q
F
Site 8
S101
L
R
L
V
I
P
R
S
D
Q
L
L
F
D
Q
Site 9
Y109
D
Q
L
L
F
D
Q
Y
T
A
E
G
L
Y
L
Site 10
T110
Q
L
L
F
D
Q
Y
T
A
E
G
L
Y
L
P
Site 11
Y115
Q
Y
T
A
E
G
L
Y
L
P
A
T
T
P
Y
Site 12
T119
E
G
L
Y
L
P
A
T
T
P
Y
R
Q
P
A
Site 13
T120
G
L
Y
L
P
A
T
T
P
Y
R
Q
P
A
W
Site 14
Y122
Y
L
P
A
T
T
P
Y
R
Q
P
A
W
G
G
Site 15
S132
P
A
W
G
G
P
D
S
A
G
P
G
E
V
R
Site 16
S142
P
G
E
V
R
L
V
S
L
R
R
A
K
A
H
Site 17
S155
A
H
E
G
L
G
F
S
I
R
G
G
S
E
H
Site 18
S160
G
F
S
I
R
G
G
S
E
H
G
V
G
I
Y
Site 19
S195
I
L
R
V
N
D
K
S
L
A
R
V
T
H
A
Site 20
T200
D
K
S
L
A
R
V
T
H
A
E
A
V
K
A
Site 21
Y228
A
G
R
I
P
G
G
Y
V
T
N
H
I
Y
T
Site 22
Y234
G
Y
V
T
N
H
I
Y
T
W
V
D
P
Q
G
Site 23
S243
W
V
D
P
Q
G
R
S
I
S
P
P
S
G
L
Site 24
S245
D
P
Q
G
R
S
I
S
P
P
S
G
L
P
Q
Site 25
S248
G
R
S
I
S
P
P
S
G
L
P
Q
P
H
G
Site 26
S267
Q
Q
E
G
D
R
R
S
T
L
H
L
L
Q
G
Site 27
T268
Q
E
G
D
R
R
S
T
L
H
L
L
Q
G
G
Site 28
T293
D
G
R
S
L
G
L
T
I
R
G
G
A
E
Y
Site 29
S313
I
T
G
V
D
P
G
S
E
A
E
G
S
G
L
Site 30
S318
P
G
S
E
A
E
G
S
G
L
K
V
G
D
Q
Site 31
T355
S
S
R
H
L
I
L
T
V
K
D
V
G
R
L
Site 32
T368
R
L
P
H
A
R
T
T
V
D
E
T
K
W
I
Site 33
T372
A
R
T
T
V
D
E
T
K
W
I
A
S
S
R
Site 34
S377
D
E
T
K
W
I
A
S
S
R
I
R
E
T
M
Site 35
S378
E
T
K
W
I
A
S
S
R
I
R
E
T
M
A
Site 36
T383
A
S
S
R
I
R
E
T
M
A
N
S
A
G
F
Site 37
T395
A
G
F
L
G
D
L
T
T
E
G
I
N
K
P
Site 38
T396
G
F
L
G
D
L
T
T
E
G
I
N
K
P
G
Site 39
Y405
G
I
N
K
P
G
F
Y
K
G
P
A
G
S
Q
Site 40
S411
F
Y
K
G
P
A
G
S
Q
V
T
L
S
S
L
Site 41
T414
G
P
A
G
S
Q
V
T
L
S
S
L
G
N
Q
Site 42
S417
G
S
Q
V
T
L
S
S
L
G
N
Q
T
R
V
Site 43
Y445
E
H
A
T
M
A
Y
Y
L
D
E
Y
R
G
G
Site 44
Y449
M
A
Y
Y
L
D
E
Y
R
G
G
S
V
S
V
Site 45
S474
L
N
T
H
A
K
F
S
L
L
S
E
V
R
G
Site 46
S477
H
A
K
F
S
L
L
S
E
V
R
G
T
I
S
Site 47
T482
L
L
S
E
V
R
G
T
I
S
P
Q
D
L
E
Site 48
S484
S
E
V
R
G
T
I
S
P
Q
D
L
E
R
F
Site 49
S502
V
L
R
R
E
I
E
S
M
K
A
R
Q
P
P
Site 50
T516
P
G
P
G
A
G
D
T
Y
S
M
V
S
Y
S
Site 51
Y517
G
P
G
A
G
D
T
Y
S
M
V
S
Y
S
D
Site 52
S518
P
G
A
G
D
T
Y
S
M
V
S
Y
S
D
T
Site 53
S521
G
D
T
Y
S
M
V
S
Y
S
D
T
G
S
S
Site 54
Y522
D
T
Y
S
M
V
S
Y
S
D
T
G
S
S
T
Site 55
S523
T
Y
S
M
V
S
Y
S
D
T
G
S
S
T
G
Site 56
T525
S
M
V
S
Y
S
D
T
G
S
S
T
G
S
H
Site 57
S527
V
S
Y
S
D
T
G
S
S
T
G
S
H
G
T
Site 58
S528
S
Y
S
D
T
G
S
S
T
G
S
H
G
T
S
Site 59
T529
Y
S
D
T
G
S
S
T
G
S
H
G
T
S
T
Site 60
S531
D
T
G
S
S
T
G
S
H
G
T
S
T
T
V
Site 61
S535
S
T
G
S
H
G
T
S
T
T
V
S
S
A
R
Site 62
T536
T
G
S
H
G
T
S
T
T
V
S
S
A
R
N
Site 63
T537
G
S
H
G
T
S
T
T
V
S
S
A
R
N
T
Site 64
S539
H
G
T
S
T
T
V
S
S
A
R
N
T
L
D
Site 65
S540
G
T
S
T
T
V
S
S
A
R
N
T
L
D
L
Site 66
T544
T
V
S
S
A
R
N
T
L
D
L
E
E
T
G
Site 67
S565
I
N
A
L
P
D
V
S
V
D
D
V
R
S
T
Site 68
S571
V
S
V
D
D
V
R
S
T
S
Q
G
L
S
S
Site 69
T572
S
V
D
D
V
R
S
T
S
Q
G
L
S
S
F
Site 70
S573
V
D
D
V
R
S
T
S
Q
G
L
S
S
F
K
Site 71
S577
R
S
T
S
Q
G
L
S
S
F
K
P
L
P
R
Site 72
S578
S
T
S
Q
G
L
S
S
F
K
P
L
P
R
P
Site 73
S611
R
E
D
L
Q
P
P
S
S
M
P
S
C
S
G
Site 74
S612
E
D
L
Q
P
P
S
S
M
P
S
C
S
G
T
Site 75
S615
Q
P
P
S
S
M
P
S
C
S
G
T
V
F
S
Site 76
S617
P
S
S
M
P
S
C
S
G
T
V
F
S
A
P
Site 77
T619
S
M
P
S
C
S
G
T
V
F
S
A
P
Q
N
Site 78
S622
S
C
S
G
T
V
F
S
A
P
Q
N
R
S
P
Site 79
S628
F
S
A
P
Q
N
R
S
P
P
A
G
T
A
P
Site 80
T636
P
P
A
G
T
A
P
T
P
G
T
S
S
A
Q
Site 81
S641
A
P
T
P
G
T
S
S
A
Q
D
L
P
S
S
Site 82
S647
S
S
A
Q
D
L
P
S
S
P
I
Y
A
S
V
Site 83
S648
S
A
Q
D
L
P
S
S
P
I
Y
A
S
V
S
Site 84
Y651
D
L
P
S
S
P
I
Y
A
S
V
S
P
A
N
Site 85
S653
P
S
S
P
I
Y
A
S
V
S
P
A
N
P
S
Site 86
S655
S
P
I
Y
A
S
V
S
P
A
N
P
S
S
K
Site 87
S661
V
S
P
A
N
P
S
S
K
R
P
L
D
A
H
Site 88
S685
G
P
F
P
R
V
Q
S
P
P
H
L
K
S
P
Site 89
S691
Q
S
P
P
H
L
K
S
P
S
A
E
A
T
V
Site 90
S693
P
P
H
L
K
S
P
S
A
E
A
T
V
A
G
Site 91
S707
G
G
C
L
L
P
P
S
P
S
G
H
P
D
Q
Site 92
S709
C
L
L
P
P
S
P
S
G
H
P
D
Q
T
G
Site 93
T715
P
S
G
H
P
D
Q
T
G
T
N
Q
H
F
V
Site 94
S731
V
E
V
H
R
P
D
S
E
P
D
V
N
E
V
Site 95
T744
E
V
R
A
L
P
Q
T
R
T
A
S
T
L
S
Site 96
T746
R
A
L
P
Q
T
R
T
A
S
T
L
S
Q
L
Site 97
S748
L
P
Q
T
R
T
A
S
T
L
S
Q
L
S
D
Site 98
T749
P
Q
T
R
T
A
S
T
L
S
Q
L
S
D
S
Site 99
S751
T
R
T
A
S
T
L
S
Q
L
S
D
S
G
Q
Site 100
S754
A
S
T
L
S
Q
L
S
D
S
G
Q
T
L
S
Site 101
S756
T
L
S
Q
L
S
D
S
G
Q
T
L
S
E
D
Site 102
T759
Q
L
S
D
S
G
Q
T
L
S
E
D
S
G
V
Site 103
S761
S
D
S
G
Q
T
L
S
E
D
S
G
V
D
A
Site 104
S764
G
Q
T
L
S
E
D
S
G
V
D
A
G
E
A
Site 105
S774
D
A
G
E
A
E
A
S
A
P
G
R
G
R
Q
Site 106
S782
A
P
G
R
G
R
Q
S
V
S
T
K
S
R
S
Site 107
S784
G
R
G
R
Q
S
V
S
T
K
S
R
S
S
K
Site 108
T785
R
G
R
Q
S
V
S
T
K
S
R
S
S
K
E
Site 109
S787
R
Q
S
V
S
T
K
S
R
S
S
K
E
L
P
Site 110
S789
S
V
S
T
K
S
R
S
S
K
E
L
P
R
N
Site 111
S790
V
S
T
K
S
R
S
S
K
E
L
P
R
N
E
Site 112
T800
L
P
R
N
E
R
P
T
D
G
A
N
K
P
P
Site 113
S814
P
G
L
L
E
P
T
S
T
L
V
R
V
K
K
Site 114
T815
G
L
L
E
P
T
S
T
L
V
R
V
K
K
S
Site 115
T836
A
I
E
G
G
A
N
T
R
Q
P
L
P
R
I
Site 116
T845
Q
P
L
P
R
I
V
T
I
Q
R
G
G
S
A
Site 117
S851
V
T
I
Q
R
G
G
S
A
H
N
C
G
Q
L
Site 118
T871
I
L
E
V
N
G
L
T
L
R
G
K
E
H
R
Site 119
T890
I
I
A
E
A
F
K
T
K
D
R
D
Y
I
D
Site 120
Y895
F
K
T
K
D
R
D
Y
I
D
F
L
V
T
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation