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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZFAT1
Full Name:
Zinc finger protein ZFAT
Alias:
ZFAT; zinc finger 406; zinc finger gene in autoimmune thyroid disease; ZN406
Type:
Transcription factor
Mass (Da):
139034
Number AA:
1243
UniProt ID:
Q9P243
International Prot ID:
IPI00418220
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
E
T
R
A
A
E
N
T
A
I
F
M
C
K
C
Site 2
S21
C
K
C
C
N
L
F
S
P
N
Q
S
E
L
L
Site 3
S25
N
L
F
S
P
N
Q
S
E
L
L
S
H
V
S
Site 4
S29
P
N
Q
S
E
L
L
S
H
V
S
E
K
H
M
Site 5
S32
S
E
L
L
S
H
V
S
E
K
H
M
E
E
G
Site 6
S53
I
I
P
L
R
P
L
S
T
P
E
P
P
N
S
Site 7
T54
I
P
L
R
P
L
S
T
P
E
P
P
N
S
S
Site 8
S60
S
T
P
E
P
P
N
S
S
K
T
G
D
E
F
Site 9
T63
E
P
P
N
S
S
K
T
G
D
E
F
L
V
M
Site 10
S80
K
R
G
R
P
K
G
S
T
K
K
S
S
T
E
Site 11
T81
R
G
R
P
K
G
S
T
K
K
S
S
T
E
E
Site 12
S84
P
K
G
S
T
K
K
S
S
T
E
E
E
L
A
Site 13
S85
K
G
S
T
K
K
S
S
T
E
E
E
L
A
E
Site 14
S96
E
L
A
E
N
I
V
S
P
T
E
D
S
P
L
Site 15
S101
I
V
S
P
T
E
D
S
P
L
A
P
E
E
G
Site 16
S110
L
A
P
E
E
G
N
S
L
P
P
S
S
L
E
Site 17
S114
E
G
N
S
L
P
P
S
S
L
E
C
S
K
C
Site 18
S115
G
N
S
L
P
P
S
S
L
E
C
S
K
C
C
Site 19
S119
P
P
S
S
L
E
C
S
K
C
C
R
K
F
S
Site 20
S126
S
K
C
C
R
K
F
S
N
T
R
Q
L
R
K
Site 21
S153
E
G
E
A
G
N
E
S
D
L
E
L
E
K
K
Site 22
S170
E
D
D
R
E
K
A
S
K
R
P
R
S
Q
K
Site 23
S175
K
A
S
K
R
P
R
S
Q
K
T
E
K
V
Q
Site 24
S193
G
K
E
A
R
Q
L
S
G
A
K
K
P
I
I
Site 25
T229
G
P
P
E
T
G
A
T
N
S
E
T
T
S
A
Site 26
S231
P
E
T
G
A
T
N
S
E
T
T
S
A
D
L
Site 27
S235
A
T
N
S
E
T
T
S
A
D
L
V
P
R
R
Site 28
Y244
D
L
V
P
R
R
G
Y
Q
E
Y
A
I
Q
Q
Site 29
Y247
P
R
R
G
Y
Q
E
Y
A
I
Q
Q
T
P
Y
Site 30
T252
Q
E
Y
A
I
Q
Q
T
P
Y
E
Q
P
M
K
Site 31
Y254
Y
A
I
Q
Q
T
P
Y
E
Q
P
M
K
S
S
Site 32
S260
P
Y
E
Q
P
M
K
S
S
R
L
G
P
T
Q
Site 33
S285
K
V
F
K
F
K
H
S
L
Q
A
H
L
R
I
Site 34
T294
Q
A
H
L
R
I
H
T
N
E
K
P
Y
K
C
Site 35
Y299
I
H
T
N
E
K
P
Y
K
C
P
Q
C
S
Y
Site 36
T322
N
V
H
L
R
K
H
T
G
E
K
F
A
C
D
Site 37
Y363
C
R
F
C
K
K
K
Y
S
D
V
K
N
L
I
Site 38
S364
R
F
C
K
K
K
Y
S
D
V
K
N
L
I
K
Site 39
Y404
E
G
K
R
Q
L
L
Y
D
C
H
I
C
E
R
Site 40
Y444
C
G
H
G
A
T
K
Y
Q
A
L
E
L
H
V
Site 41
S469
V
C
R
K
K
F
V
S
S
I
R
L
R
T
H
Site 42
S470
C
R
K
K
F
V
S
S
I
R
L
R
T
H
I
Site 43
T475
V
S
S
I
R
L
R
T
H
I
K
E
V
H
G
Site 44
S564
A
P
A
V
H
L
A
S
P
Q
A
E
S
T
A
Site 45
T579
L
P
P
C
E
L
E
T
T
V
V
S
S
S
D
Site 46
T580
P
P
C
E
L
E
T
T
V
V
S
S
S
D
L
Site 47
S583
E
L
E
T
T
V
V
S
S
S
D
L
H
S
Q
Site 48
S585
E
T
T
V
V
S
S
S
D
L
H
S
Q
E
V
Site 49
S589
V
S
S
S
D
L
H
S
Q
E
V
V
S
D
D
Site 50
S594
L
H
S
Q
E
V
V
S
D
D
F
L
L
K
N
Site 51
T603
D
F
L
L
K
N
D
T
S
S
A
E
A
H
A
Site 52
S604
F
L
L
K
N
D
T
S
S
A
E
A
H
A
A
Site 53
S605
L
L
K
N
D
T
S
S
A
E
A
H
A
A
P
Site 54
S623
P
D
M
Q
H
R
S
S
V
Q
T
Q
G
E
V
Site 55
T626
Q
H
R
S
S
V
Q
T
Q
G
E
V
I
T
L
Site 56
S640
L
L
L
S
K
A
Q
S
A
G
S
D
Q
E
S
Site 57
S643
S
K
A
Q
S
A
G
S
D
Q
E
S
H
G
A
Site 58
S647
S
A
G
S
D
Q
E
S
H
G
A
Q
S
P
L
Site 59
S652
Q
E
S
H
G
A
Q
S
P
L
G
E
G
Q
N
Site 60
S664
G
Q
N
M
A
V
L
S
A
G
D
P
D
P
S
Site 61
S671
S
A
G
D
P
D
P
S
R
C
L
R
S
N
P
Site 62
S676
D
P
S
R
C
L
R
S
N
P
A
E
A
S
D
Site 63
S682
R
S
N
P
A
E
A
S
D
L
L
P
P
V
A
Site 64
T694
P
V
A
G
G
G
D
T
I
T
H
Q
P
D
S
Site 65
T696
A
G
G
G
D
T
I
T
H
Q
P
D
S
C
K
Site 66
S701
T
I
T
H
Q
P
D
S
C
K
A
A
P
E
H
Site 67
S721
A
F
M
K
V
L
N
S
L
Q
K
K
Q
M
N
Site 68
S730
Q
K
K
Q
M
N
T
S
L
C
E
R
I
R
K
Site 69
Y739
C
E
R
I
R
K
V
Y
G
D
L
E
C
E
Y
Site 70
Y746
Y
G
D
L
E
C
E
Y
C
G
K
L
F
W
Y
Site 71
T765
D
M
H
V
R
T
H
T
R
E
H
L
Y
Y
C
Site 72
Y807
C
P
T
D
G
C
D
Y
S
T
P
D
K
Y
K
Site 73
S808
P
T
D
G
C
D
Y
S
T
P
D
K
Y
K
L
Site 74
T809
T
D
G
C
D
Y
S
T
P
D
K
Y
K
L
Q
Site 75
Y813
D
Y
S
T
P
D
K
Y
K
L
Q
A
H
L
K
Site 76
S829
H
T
A
L
D
K
R
S
Y
S
C
P
V
C
E
Site 77
Y830
T
A
L
D
K
R
S
Y
S
C
P
V
C
E
K
Site 78
S831
A
L
D
K
R
S
Y
S
C
P
V
C
E
K
S
Site 79
S838
S
C
P
V
C
E
K
S
F
S
E
D
R
L
I
Site 80
S840
P
V
C
E
K
S
F
S
E
D
R
L
I
K
S
Site 81
S847
S
E
D
R
L
I
K
S
H
I
K
T
N
H
P
Site 82
T851
L
I
K
S
H
I
K
T
N
H
P
E
V
S
M
Site 83
S857
K
T
N
H
P
E
V
S
M
S
T
I
S
E
V
Site 84
S859
N
H
P
E
V
S
M
S
T
I
S
E
V
L
G
Site 85
Y916
F
K
C
S
L
C
E
Y
A
T
R
S
K
S
N
Site 86
T918
C
S
L
C
E
Y
A
T
R
S
K
S
N
L
K
Site 87
S920
L
C
E
Y
A
T
R
S
K
S
N
L
K
A
H
Site 88
S922
E
Y
A
T
R
S
K
S
N
L
K
A
H
M
N
Site 89
S948
M
C
G
K
K
F
K
S
K
G
T
L
K
S
H
Site 90
S954
K
S
K
G
T
L
K
S
H
K
L
L
H
T
A
Site 91
Y973
F
K
C
T
V
C
D
Y
T
A
A
Q
K
P
Q
Site 92
T974
K
C
T
V
C
D
Y
T
A
A
Q
K
P
Q
L
Site 93
S1008
Y
S
C
N
I
S
G
S
L
K
R
H
Y
N
R
Site 94
Y1013
S
G
S
L
K
R
H
Y
N
R
K
H
P
N
E
Site 95
Y1022
R
K
H
P
N
E
E
Y
A
N
V
G
T
G
E
Site 96
T1081
D
P
K
W
E
T
A
T
E
A
P
E
E
P
S
Site 97
T1089
E
A
P
E
E
P
S
T
Q
Y
L
H
I
T
E
Site 98
Y1091
P
E
E
P
S
T
Q
Y
L
H
I
T
E
A
E
Site 99
Y1116
A
A
L
Q
D
L
R
Y
T
S
E
S
G
D
R
Site 100
T1117
A
L
Q
D
L
R
Y
T
S
E
S
G
D
R
L
Site 101
S1118
L
Q
D
L
R
Y
T
S
E
S
G
D
R
L
D
Site 102
S1120
D
L
R
Y
T
S
E
S
G
D
R
L
D
P
T
Site 103
T1127
S
G
D
R
L
D
P
T
A
V
N
I
L
Q
Q
Site 104
S1172
V
T
E
E
E
P
S
S
N
H
T
V
M
I
Q
Site 105
T1175
E
E
P
S
S
N
H
T
V
M
I
Q
E
T
V
Site 106
T1181
H
T
V
M
I
Q
E
T
V
Q
Q
A
S
V
E
Site 107
S1186
Q
E
T
V
Q
Q
A
S
V
E
L
A
E
Q
H
Site 108
S1199
Q
H
H
L
V
V
S
S
D
D
V
E
G
I
E
Site 109
T1207
D
D
V
E
G
I
E
T
V
T
V
Y
T
Q
G
Site 110
T1209
V
E
G
I
E
T
V
T
V
Y
T
Q
G
G
E
Site 111
Y1211
G
I
E
T
V
T
V
Y
T
Q
G
G
E
A
S
Site 112
Y1223
E
A
S
E
F
I
V
Y
V
Q
E
A
M
Q
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation