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Updated November 2019
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Protein Info
Short Name:
MBD5
Full Name:
Methyl-CpG-binding domain protein 5
Alias:
Type:
Mass (Da):
159895
Number AA:
1494
UniProt ID:
Q9P267
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S45
S
P
S
G
S
L
L
S
C
L
E
Q
V
K
T
Site 2
T52
S
C
L
E
Q
V
K
T
Y
L
L
T
D
G
T
Site 3
S115
A
V
A
T
L
H
K
S
M
E
A
P
H
P
S
Site 4
S122
S
M
E
A
P
H
P
S
L
V
L
T
S
P
G
Site 5
T126
P
H
P
S
L
V
L
T
S
P
G
G
G
T
N
Site 6
S127
H
P
S
L
V
L
T
S
P
G
G
G
T
N
A
Site 7
T135
P
G
G
G
T
N
A
T
P
V
V
P
S
R
A
Site 8
T144
V
V
P
S
R
A
A
T
P
R
S
V
R
N
K
Site 9
S147
S
R
A
A
T
P
R
S
V
R
N
K
S
H
E
Site 10
S152
P
R
S
V
R
N
K
S
H
E
G
I
T
N
S
Site 11
S159
S
H
E
G
I
T
N
S
V
M
P
E
C
K
N
Site 12
Y182
S
N
A
M
G
R
L
Y
V
Q
E
L
P
G
S
Site 13
S189
Y
V
Q
E
L
P
G
S
Q
Q
Q
E
L
H
P
Site 14
Y198
Q
Q
E
L
H
P
V
Y
P
R
Q
R
L
G
S
Site 15
S205
Y
P
R
Q
R
L
G
S
S
E
H
G
Q
K
S
Site 16
S206
P
R
Q
R
L
G
S
S
E
H
G
Q
K
S
P
Site 17
S212
S
S
E
H
G
Q
K
S
P
F
R
G
S
H
G
Site 18
S217
Q
K
S
P
F
R
G
S
H
G
G
L
P
S
P
Site 19
S223
G
S
H
G
G
L
P
S
P
A
S
S
G
S
Q
Site 20
S226
G
G
L
P
S
P
A
S
S
G
S
Q
I
Y
G
Site 21
S227
G
L
P
S
P
A
S
S
G
S
Q
I
Y
G
D
Site 22
S229
P
S
P
A
S
S
G
S
Q
I
Y
G
D
G
S
Site 23
Y232
A
S
S
G
S
Q
I
Y
G
D
G
S
I
S
P
Site 24
S236
S
Q
I
Y
G
D
G
S
I
S
P
R
T
D
P
Site 25
S238
I
Y
G
D
G
S
I
S
P
R
T
D
P
L
G
Site 26
T241
D
G
S
I
S
P
R
T
D
P
L
G
S
P
D
Site 27
S246
P
R
T
D
P
L
G
S
P
D
V
F
T
R
S
Site 28
T251
L
G
S
P
D
V
F
T
R
S
N
P
G
F
H
Site 29
S253
S
P
D
V
F
T
R
S
N
P
G
F
H
G
A
Site 30
S263
G
F
H
G
A
P
N
S
S
P
I
H
L
N
R
Site 31
S264
F
H
G
A
P
N
S
S
P
I
H
L
N
R
T
Site 32
T271
S
P
I
H
L
N
R
T
P
L
S
P
P
S
V
Site 33
S274
H
L
N
R
T
P
L
S
P
P
S
V
M
L
H
Site 34
S277
R
T
P
L
S
P
P
S
V
M
L
H
G
S
P
Site 35
S287
L
H
G
S
P
V
Q
S
S
C
A
M
A
G
R
Site 36
S288
H
G
S
P
V
Q
S
S
C
A
M
A
G
R
T
Site 37
S300
G
R
T
N
I
P
L
S
P
T
L
T
T
K
S
Site 38
T302
T
N
I
P
L
S
P
T
L
T
T
K
S
P
V
Site 39
T304
I
P
L
S
P
T
L
T
T
K
S
P
V
M
K
Site 40
T305
P
L
S
P
T
L
T
T
K
S
P
V
M
K
K
Site 41
S307
S
P
T
L
T
T
K
S
P
V
M
K
K
P
M
Site 42
S343
P
P
P
P
P
P
P
S
C
A
L
Q
K
K
P
Site 43
T352
A
L
Q
K
K
P
L
T
S
E
K
D
P
L
G
Site 44
S366
G
I
L
D
P
I
P
S
K
P
V
N
Q
N
P
Site 45
S380
P
V
I
I
N
P
T
S
F
H
S
N
V
H
S
Site 46
S383
I
N
P
T
S
F
H
S
N
V
H
S
Q
V
P
Site 47
T411
P
S
N
L
P
L
P
T
V
K
P
G
H
M
N
Site 48
S429
H
V
Q
R
V
Q
H
S
A
S
T
S
L
S
P
Site 49
S431
Q
R
V
Q
H
S
A
S
T
S
L
S
P
S
P
Site 50
S433
V
Q
H
S
A
S
T
S
L
S
P
S
P
V
T
Site 51
S435
H
S
A
S
T
S
L
S
P
S
P
V
T
S
P
Site 52
S437
A
S
T
S
L
S
P
S
P
V
T
S
P
V
H
Site 53
T440
S
L
S
P
S
P
V
T
S
P
V
H
M
M
G
Site 54
S456
G
I
G
R
I
E
A
S
P
Q
R
S
R
S
S
Site 55
S460
I
E
A
S
P
Q
R
S
R
S
S
S
T
S
S
Site 56
S462
A
S
P
Q
R
S
R
S
S
S
T
S
S
D
H
Site 57
S463
S
P
Q
R
S
R
S
S
S
T
S
S
D
H
G
Site 58
S464
P
Q
R
S
R
S
S
S
T
S
S
D
H
G
N
Site 59
S466
R
S
R
S
S
S
T
S
S
D
H
G
N
F
M
Site 60
S467
S
R
S
S
S
T
S
S
D
H
G
N
F
M
M
Site 61
S484
V
G
P
Q
A
T
S
S
G
I
K
V
P
P
R
Site 62
S492
G
I
K
V
P
P
R
S
P
R
S
T
I
G
S
Site 63
S495
V
P
P
R
S
P
R
S
T
I
G
S
P
R
P
Site 64
T496
P
P
R
S
P
R
S
T
I
G
S
P
R
P
S
Site 65
S499
S
P
R
S
T
I
G
S
P
R
P
S
M
P
S
Site 66
S503
T
I
G
S
P
R
P
S
M
P
S
S
P
S
T
Site 67
S506
S
P
R
P
S
M
P
S
S
P
S
T
K
S
D
Site 68
S507
P
R
P
S
M
P
S
S
P
S
T
K
S
D
G
Site 69
S509
P
S
M
P
S
S
P
S
T
K
S
D
G
H
H
Site 70
T510
S
M
P
S
S
P
S
T
K
S
D
G
H
H
Q
Site 71
S512
P
S
S
P
S
T
K
S
D
G
H
H
Q
Y
K
Site 72
S537
S
N
V
L
N
T
P
S
S
A
A
F
P
T
A
Site 73
S538
N
V
L
N
T
P
S
S
A
A
F
P
T
A
S
Site 74
T543
P
S
S
A
A
F
P
T
A
S
A
G
S
S
S
Site 75
S545
S
A
A
F
P
T
A
S
A
G
S
S
S
V
K
Site 76
S548
F
P
T
A
S
A
G
S
S
S
V
K
S
Q
P
Site 77
S549
P
T
A
S
A
G
S
S
S
V
K
S
Q
P
G
Site 78
S550
T
A
S
A
G
S
S
S
V
K
S
Q
P
G
L
Site 79
S553
A
G
S
S
S
V
K
S
Q
P
G
L
L
G
M
Site 80
S573
L
N
Q
H
N
A
A
S
F
P
A
S
S
L
L
Site 81
S577
N
A
A
S
F
P
A
S
S
L
L
S
A
A
A
Site 82
S599
N
K
L
A
G
N
N
S
S
S
S
S
N
S
G
Site 83
S600
K
L
A
G
N
N
S
S
S
S
S
N
S
G
A
Site 84
S601
L
A
G
N
N
S
S
S
S
S
N
S
G
A
V
Site 85
S602
A
G
N
N
S
S
S
S
S
N
S
G
A
V
A
Site 86
S603
G
N
N
S
S
S
S
S
N
S
G
A
V
A
G
Site 87
S605
N
S
S
S
S
S
N
S
G
A
V
A
G
S
G
Site 88
S611
N
S
G
A
V
A
G
S
G
N
T
E
G
H
S
Site 89
T619
G
N
T
E
G
H
S
T
L
N
T
M
F
P
P
Site 90
T622
E
G
H
S
T
L
N
T
M
F
P
P
T
A
N
Site 91
S639
L
P
T
G
E
G
Q
S
G
R
A
A
L
R
D
Site 92
S650
A
L
R
D
K
L
M
S
Q
Q
K
D
A
L
R
Site 93
T664
R
K
R
K
Q
P
P
T
T
V
L
S
L
L
R
Site 94
T665
K
R
K
Q
P
P
T
T
V
L
S
L
L
R
Q
Site 95
S668
Q
P
P
T
T
V
L
S
L
L
R
Q
S
Q
M
Site 96
S677
L
R
Q
S
Q
M
D
S
S
A
V
P
K
P
G
Site 97
S678
R
Q
S
Q
M
D
S
S
A
V
P
K
P
G
P
Site 98
S695
L
R
K
Q
G
Q
G
S
F
P
I
S
S
M
S
Site 99
S699
G
Q
G
S
F
P
I
S
S
M
S
Q
L
L
Q
Site 100
S700
Q
G
S
F
P
I
S
S
M
S
Q
L
L
Q
S
Site 101
S702
S
F
P
I
S
S
M
S
Q
L
L
Q
S
M
S
Site 102
S707
S
M
S
Q
L
L
Q
S
M
S
C
Q
S
S
H
Site 103
S709
S
Q
L
L
Q
S
M
S
C
Q
S
S
H
L
S
Site 104
S712
L
Q
S
M
S
C
Q
S
S
H
L
S
S
N
S
Site 105
S713
Q
S
M
S
C
Q
S
S
H
L
S
S
N
S
T
Site 106
S716
S
C
Q
S
S
H
L
S
S
N
S
T
P
G
C
Site 107
S717
C
Q
S
S
H
L
S
S
N
S
T
P
G
C
G
Site 108
S719
S
S
H
L
S
S
N
S
T
P
G
C
G
A
S
Site 109
T720
S
H
L
S
S
N
S
T
P
G
C
G
A
S
N
Site 110
S726
S
T
P
G
C
G
A
S
N
T
A
L
P
C
S
Site 111
T728
P
G
C
G
A
S
N
T
A
L
P
C
S
A
N
Site 112
S733
S
N
T
A
L
P
C
S
A
N
Q
L
H
F
T
Site 113
T740
S
A
N
Q
L
H
F
T
D
P
S
M
N
S
S
Site 114
S743
Q
L
H
F
T
D
P
S
M
N
S
S
V
L
Q
Site 115
S747
T
D
P
S
M
N
S
S
V
L
Q
N
I
P
L
Site 116
S771
A
N
T
N
F
V
H
S
N
S
P
V
P
N
H
Site 117
S773
T
N
F
V
H
S
N
S
P
V
P
N
H
H
L
Site 118
S799
N
C
G
M
L
S
Q
S
G
M
A
L
G
N
S
Site 119
S806
S
G
M
A
L
G
N
S
L
H
P
N
P
P
Q
Site 120
S814
L
H
P
N
P
P
Q
S
R
I
S
T
S
S
T
Site 121
S817
N
P
P
Q
S
R
I
S
T
S
S
T
P
V
I
Site 122
T818
P
P
Q
S
R
I
S
T
S
S
T
P
V
I
P
Site 123
S819
P
Q
S
R
I
S
T
S
S
T
P
V
I
P
N
Site 124
S820
Q
S
R
I
S
T
S
S
T
P
V
I
P
N
S
Site 125
T821
S
R
I
S
T
S
S
T
P
V
I
P
N
S
I
Site 126
S827
S
T
P
V
I
P
N
S
I
V
S
S
Y
N
Q
Site 127
S830
V
I
P
N
S
I
V
S
S
Y
N
Q
T
S
S
Site 128
S831
I
P
N
S
I
V
S
S
Y
N
Q
T
S
S
E
Site 129
Y832
P
N
S
I
V
S
S
Y
N
Q
T
S
S
E
A
Site 130
T835
I
V
S
S
Y
N
Q
T
S
S
E
A
G
G
S
Site 131
S836
V
S
S
Y
N
Q
T
S
S
E
A
G
G
S
G
Site 132
S837
S
S
Y
N
Q
T
S
S
E
A
G
G
S
G
P
Site 133
S842
T
S
S
E
A
G
G
S
G
P
S
S
S
I
A
Site 134
S847
G
G
S
G
P
S
S
S
I
A
I
A
G
T
N
Site 135
T861
N
H
P
A
I
T
K
T
T
S
V
L
Q
D
G
Site 136
S881
A
A
G
N
P
L
Q
S
Q
L
P
I
G
S
D
Site 137
S887
Q
S
Q
L
P
I
G
S
D
F
P
F
V
G
Q
Site 138
S902
E
H
A
L
H
F
P
S
N
S
T
S
N
N
H
Site 139
S904
A
L
H
F
P
S
N
S
T
S
N
N
H
L
P
Site 140
S906
H
F
P
S
N
S
T
S
N
N
H
L
P
H
P
Site 141
S952
S
A
G
E
G
D
M
S
S
I
N
N
T
L
S
Site 142
S953
A
G
E
G
D
M
S
S
I
N
N
T
L
S
N
Site 143
T957
D
M
S
S
I
N
N
T
L
S
N
H
Q
L
T
Site 144
S959
S
S
I
N
N
T
L
S
N
H
Q
L
T
H
L
Site 145
T964
T
L
S
N
H
Q
L
T
H
L
Q
S
L
L
N
Site 146
S1033
A
L
L
N
K
R
I
S
T
Q
P
G
L
T
A
Site 147
T1047
A
L
P
E
N
P
N
T
T
L
P
P
F
Q
D
Site 148
T1048
L
P
E
N
P
N
T
T
L
P
P
F
Q
D
T
Site 149
T1055
T
L
P
P
F
Q
D
T
P
C
E
L
Q
P
R
Site 150
S1066
L
Q
P
R
I
D
P
S
L
G
Q
Q
V
K
D
Site 151
S1161
H
D
G
R
L
R
N
S
R
G
A
R
L
P
K
Site 152
Y1184
N
E
G
D
G
F
E
Y
F
K
S
A
S
C
H
Site 153
S1187
D
G
F
E
Y
F
K
S
A
S
C
H
T
S
K
Site 154
S1193
K
S
A
S
C
H
T
S
K
K
Q
W
D
G
E
Site 155
S1202
K
Q
W
D
G
E
Q
S
P
R
G
E
R
N
R
Site 156
Y1212
G
E
R
N
R
W
K
Y
E
E
F
L
D
H
P
Site 157
S1224
D
H
P
G
H
I
H
S
S
P
C
H
E
R
P
Site 158
S1225
H
P
G
H
I
H
S
S
P
C
H
E
R
P
N
Site 159
S1235
H
E
R
P
N
N
V
S
T
L
P
F
L
P
G
Site 160
T1236
E
R
P
N
N
V
S
T
L
P
F
L
P
G
E
Site 161
Y1266
I
L
E
E
N
F
R
Y
N
N
Y
K
R
T
M
Site 162
Y1269
E
N
F
R
Y
N
N
Y
K
R
T
M
M
S
F
Site 163
S1275
N
Y
K
R
T
M
M
S
F
K
E
R
L
E
N
Site 164
T1283
F
K
E
R
L
E
N
T
V
E
R
C
A
H
I
Site 165
S1298
N
G
N
R
P
R
Q
S
R
G
F
G
E
L
L
Site 166
S1306
R
G
F
G
E
L
L
S
T
A
K
Q
D
L
V
Site 167
S1318
D
L
V
L
E
E
Q
S
P
S
S
S
N
S
L
Site 168
S1320
V
L
E
E
Q
S
P
S
S
S
N
S
L
E
N
Site 169
S1321
L
E
E
Q
S
P
S
S
S
N
S
L
E
N
S
Site 170
S1322
E
E
Q
S
P
S
S
S
N
S
L
E
N
S
L
Site 171
S1324
Q
S
P
S
S
S
N
S
L
E
N
S
L
V
K
Site 172
S1328
S
S
N
S
L
E
N
S
L
V
K
D
Y
I
H
Site 173
Y1333
E
N
S
L
V
K
D
Y
I
H
Y
N
G
D
F
Site 174
Y1336
L
V
K
D
Y
I
H
Y
N
G
D
F
N
A
K
Site 175
S1344
N
G
D
F
N
A
K
S
V
N
G
C
V
P
S
Site 176
S1351
S
V
N
G
C
V
P
S
P
S
D
A
K
S
I
Site 177
S1353
N
G
C
V
P
S
P
S
D
A
K
S
I
S
S
Site 178
S1357
P
S
P
S
D
A
K
S
I
S
S
E
D
D
L
Site 179
S1359
P
S
D
A
K
S
I
S
S
E
D
D
L
R
N
Site 180
S1369
D
D
L
R
N
P
D
S
P
S
S
N
E
L
I
Site 181
S1371
L
R
N
P
D
S
P
S
S
N
E
L
I
H
Y
Site 182
S1372
R
N
P
D
S
P
S
S
N
E
L
I
H
Y
R
Site 183
Y1378
S
S
N
E
L
I
H
Y
R
P
R
T
F
N
V
Site 184
T1382
L
I
H
Y
R
P
R
T
F
N
V
G
D
L
V
Site 185
T1397
W
G
Q
I
K
G
L
T
S
W
P
G
K
L
V
Site 186
S1398
G
Q
I
K
G
L
T
S
W
P
G
K
L
V
R
Site 187
S1412
R
E
D
D
V
H
N
S
C
Q
Q
S
P
E
E
Site 188
S1416
V
H
N
S
C
Q
Q
S
P
E
E
G
K
V
E
Site 189
T1429
V
E
P
E
K
L
K
T
L
T
E
G
L
E
A
Site 190
Y1437
L
T
E
G
L
E
A
Y
S
R
V
R
K
R
N
Site 191
S1447
V
R
K
R
N
R
K
S
G
K
L
N
N
H
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation