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Updated November 2019
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Protein Info
Short Name:
USP36
Full Name:
Ubiquitin carboxyl-terminal hydrolase 36
Alias:
Deubiquitinating enzyme 36; DUB1; EC 3.1.2.15; Ubiquitin carboxyl-terminal hydrolase 36; Ubiquitin thiolesterase 36; UBP36
Type:
Protease, Ubiquitin conjugating system
Mass (Da):
122652
Number AA:
1121
UniProt ID:
Q9P275
International Prot ID:
IPI00001786
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
L
K
P
G
R
K
D
S
A
D
D
G
E
L
G
Site 2
S46
K
I
E
F
E
P
A
S
K
S
F
S
Y
Q
L
Site 3
S48
E
F
E
P
A
S
K
S
F
S
Y
Q
L
E
A
Site 4
S50
E
P
A
S
K
S
F
S
Y
Q
L
E
A
L
K
Site 5
S58
Y
Q
L
E
A
L
K
S
K
Y
V
L
L
N
P
Site 6
Y60
L
E
A
L
K
S
K
Y
V
L
L
N
P
K
T
Site 7
T67
Y
V
L
L
N
P
K
T
E
G
A
S
R
H
K
Site 8
S75
E
G
A
S
R
H
K
S
G
D
D
P
P
A
R
Site 9
S86
P
P
A
R
R
Q
G
S
E
H
T
Y
E
S
C
Site 10
Y90
R
Q
G
S
E
H
T
Y
E
S
C
G
D
G
V
Site 11
T107
P
Q
K
V
L
F
P
T
E
R
L
S
L
R
W
Site 12
S111
L
F
P
T
E
R
L
S
L
R
W
E
R
V
F
Site 13
Y149
Y
T
P
P
L
A
N
Y
L
L
S
K
E
H
A
Site 14
S152
P
L
A
N
Y
L
L
S
K
E
H
A
R
S
C
Site 15
S158
L
S
K
E
H
A
R
S
C
H
Q
G
S
F
C
Site 16
S189
G
N
A
I
K
P
V
S
F
I
R
D
L
K
K
Site 17
Y215
D
A
H
E
F
L
R
Y
T
I
D
A
M
Q
K
Site 18
T216
A
H
E
F
L
R
Y
T
I
D
A
M
Q
K
A
Site 19
T235
C
A
K
L
D
R
Q
T
Q
A
T
T
L
V
H
Site 20
T238
L
D
R
Q
T
Q
A
T
T
L
V
H
Q
I
F
Site 21
Y248
V
H
Q
I
F
G
G
Y
L
R
S
R
V
K
C
Site 22
S256
L
R
S
R
V
K
C
S
V
C
K
S
V
S
D
Site 23
S260
V
K
C
S
V
C
K
S
V
S
D
T
Y
D
P
Site 24
S262
C
S
V
C
K
S
V
S
D
T
Y
D
P
Y
L
Site 25
T264
V
C
K
S
V
S
D
T
Y
D
P
Y
L
D
V
Site 26
Y265
C
K
S
V
S
D
T
Y
D
P
Y
L
D
V
A
Site 27
Y268
V
S
D
T
Y
D
P
Y
L
D
V
A
L
E
I
Site 28
Y300
V
L
S
G
E
N
A
Y
M
C
A
K
C
K
K
Site 29
S312
C
K
K
K
V
P
A
S
K
R
F
T
I
H
R
Site 30
T316
V
P
A
S
K
R
F
T
I
H
R
T
S
N
V
Site 31
T325
H
R
T
S
N
V
L
T
L
S
L
K
R
F
A
Site 32
S335
L
K
R
F
A
N
F
S
G
G
K
I
T
K
D
Site 33
Y345
K
I
T
K
D
V
G
Y
P
E
F
L
N
I
R
Site 34
Y354
E
F
L
N
I
R
P
Y
M
S
Q
N
N
G
D
Site 35
S356
L
N
I
R
P
Y
M
S
Q
N
N
G
D
P
V
Site 36
Y384
S
C
H
A
G
H
Y
Y
C
Y
V
K
A
S
N
Site 37
Y386
H
A
G
H
Y
Y
C
Y
V
K
A
S
N
G
Q
Site 38
Y395
K
A
S
N
G
Q
W
Y
Q
M
N
D
S
L
V
Site 39
S405
N
D
S
L
V
H
S
S
N
V
K
V
V
L
N
Site 40
Y420
Q
Q
A
Y
V
L
F
Y
L
R
I
P
G
S
K
Site 41
S426
F
Y
L
R
I
P
G
S
K
K
S
P
E
G
L
Site 42
S429
R
I
P
G
S
K
K
S
P
E
G
L
I
S
R
Site 43
S435
K
S
P
E
G
L
I
S
R
T
G
S
S
S
L
Site 44
T437
P
E
G
L
I
S
R
T
G
S
S
S
L
P
G
Site 45
S439
G
L
I
S
R
T
G
S
S
S
L
P
G
R
P
Site 46
S441
I
S
R
T
G
S
S
S
L
P
G
R
P
S
V
Site 47
S447
S
S
L
P
G
R
P
S
V
I
P
D
H
S
K
Site 48
S453
P
S
V
I
P
D
H
S
K
K
N
I
G
N
G
Site 49
S464
I
G
N
G
I
I
S
S
P
L
T
G
K
R
Q
Site 50
T467
G
I
I
S
S
P
L
T
G
K
R
Q
D
S
G
Site 51
S473
L
T
G
K
R
Q
D
S
G
T
M
K
K
P
H
Site 52
T475
G
K
R
Q
D
S
G
T
M
K
K
P
H
T
T
Site 53
T481
G
T
M
K
K
P
H
T
T
E
E
I
G
V
P
Site 54
S490
E
E
I
G
V
P
I
S
R
N
G
S
T
L
G
Site 55
S494
V
P
I
S
R
N
G
S
T
L
G
L
K
S
Q
Site 56
S500
G
S
T
L
G
L
K
S
Q
N
G
C
I
P
P
Site 57
S511
C
I
P
P
K
L
P
S
G
S
P
S
P
K
L
Site 58
S513
P
P
K
L
P
S
G
S
P
S
P
K
L
S
Q
Site 59
S515
K
L
P
S
G
S
P
S
P
K
L
S
Q
T
P
Site 60
S519
G
S
P
S
P
K
L
S
Q
T
P
T
H
M
P
Site 61
T521
P
S
P
K
L
S
Q
T
P
T
H
M
P
T
I
Site 62
T523
P
K
L
S
Q
T
P
T
H
M
P
T
I
L
D
Site 63
S546
P
A
P
P
Q
H
F
S
P
R
T
A
Q
G
L
Site 64
T549
P
Q
H
F
S
P
R
T
A
Q
G
L
P
G
T
Site 65
T556
T
A
Q
G
L
P
G
T
S
N
S
N
S
S
R
Site 66
S557
A
Q
G
L
P
G
T
S
N
S
N
S
S
R
S
Site 67
S559
G
L
P
G
T
S
N
S
N
S
S
R
S
G
S
Site 68
S561
P
G
T
S
N
S
N
S
S
R
S
G
S
Q
R
Site 69
S562
G
T
S
N
S
N
S
S
R
S
G
S
Q
R
Q
Site 70
S564
S
N
S
N
S
S
R
S
G
S
Q
R
Q
G
S
Site 71
S566
S
N
S
S
R
S
G
S
Q
R
Q
G
S
W
D
Site 72
S571
S
G
S
Q
R
Q
G
S
W
D
S
R
D
V
V
Site 73
S574
Q
R
Q
G
S
W
D
S
R
D
V
V
L
S
T
Site 74
S580
D
S
R
D
V
V
L
S
T
S
P
K
L
L
A
Site 75
S582
R
D
V
V
L
S
T
S
P
K
L
L
A
T
A
Site 76
T590
P
K
L
L
A
T
A
T
A
N
G
H
G
L
K
Site 77
S602
G
L
K
G
N
D
E
S
A
G
L
D
R
R
G
Site 78
S610
A
G
L
D
R
R
G
S
S
S
S
S
P
E
H
Site 79
S611
G
L
D
R
R
G
S
S
S
S
S
P
E
H
S
Site 80
S612
L
D
R
R
G
S
S
S
S
S
P
E
H
S
A
Site 81
S613
D
R
R
G
S
S
S
S
S
P
E
H
S
A
S
Site 82
S614
R
R
G
S
S
S
S
S
P
E
H
S
A
S
S
Site 83
S618
S
S
S
S
P
E
H
S
A
S
S
D
S
T
K
Site 84
S620
S
S
P
E
H
S
A
S
S
D
S
T
K
A
P
Site 85
S621
S
P
E
H
S
A
S
S
D
S
T
K
A
P
Q
Site 86
S623
E
H
S
A
S
S
D
S
T
K
A
P
Q
T
P
Site 87
T624
H
S
A
S
S
D
S
T
K
A
P
Q
T
P
R
Site 88
T629
D
S
T
K
A
P
Q
T
P
R
S
G
A
A
H
Site 89
S632
K
A
P
Q
T
P
R
S
G
A
A
H
L
C
D
Site 90
S640
G
A
A
H
L
C
D
S
Q
E
T
N
C
S
T
Site 91
S646
D
S
Q
E
T
N
C
S
T
A
G
H
S
K
T
Site 92
S651
N
C
S
T
A
G
H
S
K
T
P
P
S
G
A
Site 93
T653
S
T
A
G
H
S
K
T
P
P
S
G
A
D
S
Site 94
S656
G
H
S
K
T
P
P
S
G
A
D
S
K
T
V
Site 95
S660
T
P
P
S
G
A
D
S
K
T
V
K
L
K
S
Site 96
T662
P
S
G
A
D
S
K
T
V
K
L
K
S
P
V
Site 97
S667
S
K
T
V
K
L
K
S
P
V
L
S
N
T
T
Site 98
S671
K
L
K
S
P
V
L
S
N
T
T
T
E
P
A
Site 99
T675
P
V
L
S
N
T
T
T
E
P
A
S
T
M
S
Site 100
S679
N
T
T
T
E
P
A
S
T
M
S
P
P
P
A
Site 101
T680
T
T
T
E
P
A
S
T
M
S
P
P
P
A
K
Site 102
S682
T
E
P
A
S
T
M
S
P
P
P
A
K
K
L
Site 103
S692
P
A
K
K
L
A
L
S
A
K
K
A
S
T
L
Site 104
T698
L
S
A
K
K
A
S
T
L
W
R
A
T
G
N
Site 105
T703
A
S
T
L
W
R
A
T
G
N
D
L
R
P
P
Site 106
S713
D
L
R
P
P
P
P
S
P
S
S
D
L
T
H
Site 107
S715
R
P
P
P
P
S
P
S
S
D
L
T
H
P
M
Site 108
S716
P
P
P
P
S
P
S
S
D
L
T
H
P
M
K
Site 109
T719
P
S
P
S
S
D
L
T
H
P
M
K
T
S
H
Site 110
S725
L
T
H
P
M
K
T
S
H
P
V
V
A
S
T
Site 111
S731
T
S
H
P
V
V
A
S
T
W
P
V
H
R
A
Site 112
S742
V
H
R
A
R
A
V
S
P
A
P
Q
S
S
S
Site 113
S747
A
V
S
P
A
P
Q
S
S
S
R
L
Q
P
P
Site 114
S748
V
S
P
A
P
Q
S
S
S
R
L
Q
P
P
F
Site 115
S749
S
P
A
P
Q
S
S
S
R
L
Q
P
P
F
S
Site 116
S756
S
R
L
Q
P
P
F
S
P
H
P
T
L
L
S
Site 117
T760
P
P
F
S
P
H
P
T
L
L
S
S
T
P
K
Site 118
S763
S
P
H
P
T
L
L
S
S
T
P
K
P
P
G
Site 119
S764
P
H
P
T
L
L
S
S
T
P
K
P
P
G
T
Site 120
T765
H
P
T
L
L
S
S
T
P
K
P
P
G
T
S
Site 121
T771
S
T
P
K
P
P
G
T
S
E
P
R
S
C
S
Site 122
S772
T
P
K
P
P
G
T
S
E
P
R
S
C
S
S
Site 123
S776
P
G
T
S
E
P
R
S
C
S
S
I
S
T
A
Site 124
S778
T
S
E
P
R
S
C
S
S
I
S
T
A
L
P
Site 125
S779
S
E
P
R
S
C
S
S
I
S
T
A
L
P
Q
Site 126
T782
R
S
C
S
S
I
S
T
A
L
P
Q
V
N
E
Site 127
S793
Q
V
N
E
D
L
V
S
L
P
H
Q
L
P
E
Site 128
S802
P
H
Q
L
P
E
A
S
E
P
P
Q
S
P
S
Site 129
S807
E
A
S
E
P
P
Q
S
P
S
E
K
R
K
K
Site 130
S809
S
E
P
P
Q
S
P
S
E
K
R
K
K
T
F
Site 131
T815
P
S
E
K
R
K
K
T
F
V
G
E
P
Q
R
Site 132
S825
G
E
P
Q
R
L
G
S
E
T
R
L
P
Q
H
Site 133
T827
P
Q
R
L
G
S
E
T
R
L
P
Q
H
I
R
Site 134
T837
P
Q
H
I
R
E
A
T
A
A
P
H
G
K
R
Site 135
T865
S
A
L
Q
E
G
Q
T
Q
R
Q
P
G
S
P
Site 136
S871
Q
T
Q
R
Q
P
G
S
P
M
Y
R
R
E
G
Site 137
Y874
R
Q
P
G
S
P
M
Y
R
R
E
G
Q
A
Q
Site 138
T892
V
R
R
Q
E
D
G
T
Q
P
Q
V
N
G
Q
Site 139
S911
V
T
D
G
H
H
A
S
S
R
K
R
R
R
K
Site 140
S912
T
D
G
H
H
A
S
S
R
K
R
R
R
K
G
Site 141
S937
H
Q
D
P
L
R
H
S
C
S
P
M
G
D
G
Site 142
S939
D
P
L
R
H
S
C
S
P
M
G
D
G
D
P
Site 143
S952
D
P
E
A
M
E
E
S
P
R
K
K
K
K
K
Site 144
T963
K
K
K
R
K
Q
E
T
Q
R
A
V
E
E
D
Site 145
S978
G
H
L
K
C
P
R
S
A
K
P
Q
D
A
V
Site 146
S989
Q
D
A
V
V
P
E
S
S
S
C
A
P
S
A
Site 147
S990
D
A
V
V
P
E
S
S
S
C
A
P
S
A
N
Site 148
S991
A
V
V
P
E
S
S
S
C
A
P
S
A
N
G
Site 149
S995
E
S
S
S
C
A
P
S
A
N
G
W
C
P
G
Site 150
S1008
P
G
D
R
M
G
L
S
Q
A
P
P
V
S
W
Site 151
S1014
L
S
Q
A
P
P
V
S
W
N
G
E
R
E
S
Site 152
S1021
S
W
N
G
E
R
E
S
D
V
V
Q
E
L
L
Site 153
Y1030
V
V
Q
E
L
L
K
Y
S
S
D
K
A
Y
G
Site 154
S1032
Q
E
L
L
K
Y
S
S
D
K
A
Y
G
R
K
Site 155
Y1036
K
Y
S
S
D
K
A
Y
G
R
K
V
L
T
W
Site 156
T1042
A
Y
G
R
K
V
L
T
W
D
G
K
M
S
A
Site 157
S1051
D
G
K
M
S
A
V
S
Q
D
A
I
E
D
S
Site 158
S1058
S
Q
D
A
I
E
D
S
R
Q
A
R
T
E
T
Site 159
T1065
S
R
Q
A
R
T
E
T
V
V
D
D
W
D
E
Site 160
S1107
Q
T
R
R
N
F
W
S
V
T
H
P
A
K
A
Site 161
S1116
T
H
P
A
K
A
A
S
L
S
Y
R
R
_
_
Site 162
S1118
P
A
K
A
A
S
L
S
Y
R
R
_
_
_
_
Site 163
Y1119
A
K
A
A
S
L
S
Y
R
R
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation