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Updated November 2019
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Protein Info
Short Name:
IBTK
Full Name:
Inhibitor of Bruton tyrosine kinase
Alias:
Bruton agammaglobulinemia tyrosine kinase inhibitor; BTK-binding protein; BTKI; DKFZP564B116; Inhibitor of Bruton agammaglobulinemia tyrosine kinase; Inhibitor of Bruton tyrosine kinase: Inhibitor of Bruton tyrosine kinase
Type:
Protein kinase, regulatory subunit
Mass (Da):
150528
Number AA:
1353
UniProt ID:
Q9P2D0
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0019901
GO:0030292
PhosphoSite+
KinaseNET
Biological Process:
GO:0001933
GO:0051209
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
S
S
P
M
P
D
C
T
S
K
C
R
S
L
K
Site 2
S10
S
P
M
P
D
C
T
S
K
C
R
S
L
K
H
Site 3
S14
D
C
T
S
K
C
R
S
L
K
H
A
L
D
V
Site 4
S23
K
H
A
L
D
V
L
S
V
V
T
K
G
S
E
Site 5
Y42
A
F
L
S
S
H
C
Y
N
A
A
T
I
K
D
Site 6
S60
R
N
A
L
H
L
V
S
S
C
G
K
K
G
V
Site 7
T88
K
D
K
E
S
G
W
T
A
L
H
R
S
I
F
Site 8
Y96
A
L
H
R
S
I
F
Y
G
H
I
D
C
V
W
Site 9
S104
G
H
I
D
C
V
W
S
L
L
K
H
G
V
S
Site 10
S111
S
L
L
K
H
G
V
S
L
Y
I
Q
D
K
E
Site 11
Y113
L
K
H
G
V
S
L
Y
I
Q
D
K
E
G
L
Site 12
T132
L
V
M
K
D
R
P
T
H
V
V
F
K
N
T
Site 13
Y145
N
T
D
P
T
D
V
Y
T
W
G
D
N
T
N
Site 14
S159
N
F
T
L
G
H
G
S
Q
N
S
K
H
H
P
Site 15
S162
L
G
H
G
S
Q
N
S
K
H
H
P
E
L
V
Site 16
Y178
L
F
S
R
S
G
I
Y
I
K
Q
V
V
L
C
Site 17
S193
K
F
H
S
V
F
L
S
Q
K
G
Q
V
Y
T
Site 18
Y199
L
S
Q
K
G
Q
V
Y
T
C
G
H
G
P
G
Site 19
T200
S
Q
K
G
Q
V
Y
T
C
G
H
G
P
G
G
Site 20
S232
G
L
N
G
H
N
C
S
Q
V
A
A
A
K
D
Site 21
S268
L
G
I
I
P
P
P
S
S
C
N
V
P
R
Q
Site 22
S269
G
I
I
P
P
P
S
S
C
N
V
P
R
Q
I
Site 23
Y280
P
R
Q
I
Q
A
K
Y
L
K
G
R
T
I
I
Site 24
T285
A
K
Y
L
K
G
R
T
I
I
G
V
A
A
G
Site 25
T296
V
A
A
G
R
F
H
T
V
L
W
T
R
E
A
Site 26
T300
R
F
H
T
V
L
W
T
R
E
A
V
Y
T
M
Site 27
T327
P
N
G
E
K
C
V
T
A
P
R
Q
V
S
A
Site 28
S333
V
T
A
P
R
Q
V
S
A
L
H
H
K
D
I
Site 29
Y367
D
I
Y
L
L
A
D
Y
Q
C
K
K
M
A
S
Site 30
Y391
V
S
G
G
H
M
E
Y
K
V
D
P
E
H
L
Site 31
S422
G
R
V
F
C
W
R
S
V
N
S
S
L
K
Q
Site 32
Y434
L
K
Q
C
R
W
A
Y
P
R
Q
V
F
I
S
Site 33
S441
Y
P
R
Q
V
F
I
S
D
I
A
L
N
R
N
Site 34
T454
R
N
E
I
L
F
V
T
Q
D
G
E
G
F
R
Site 35
S471
W
F
E
E
K
R
K
S
S
E
K
K
E
I
L
Site 36
S472
F
E
E
K
R
K
S
S
E
K
K
E
I
L
S
Site 37
S479
S
E
K
K
E
I
L
S
N
L
H
N
S
S
S
Site 38
S484
I
L
S
N
L
H
N
S
S
S
D
V
S
Y
V
Site 39
S485
L
S
N
L
H
N
S
S
S
D
V
S
Y
V
S
Site 40
S486
S
N
L
H
N
S
S
S
D
V
S
Y
V
S
D
Site 41
S489
H
N
S
S
S
D
V
S
Y
V
S
D
I
N
S
Site 42
Y490
N
S
S
S
D
V
S
Y
V
S
D
I
N
S
V
Site 43
S492
S
S
D
V
S
Y
V
S
D
I
N
S
V
Y
E
Site 44
S496
S
Y
V
S
D
I
N
S
V
Y
E
R
I
R
L
Site 45
Y498
V
S
D
I
N
S
V
Y
E
R
I
R
L
E
K
Site 46
T507
R
I
R
L
E
K
L
T
F
A
H
R
A
V
S
Site 47
S514
T
F
A
H
R
A
V
S
V
S
T
D
P
S
G
Site 48
S516
A
H
R
A
V
S
V
S
T
D
P
S
G
C
N
Site 49
S529
C
N
F
A
I
L
Q
S
D
P
K
T
S
L
Y
Site 50
T533
I
L
Q
S
D
P
K
T
S
L
Y
E
I
P
A
Site 51
S534
L
Q
S
D
P
K
T
S
L
Y
E
I
P
A
V
Site 52
Y536
S
D
P
K
T
S
L
Y
E
I
P
A
V
S
S
Site 53
S542
L
Y
E
I
P
A
V
S
S
S
S
F
F
E
E
Site 54
S543
Y
E
I
P
A
V
S
S
S
S
F
F
E
E
F
Site 55
S544
E
I
P
A
V
S
S
S
S
F
F
E
E
F
G
Site 56
S545
I
P
A
V
S
S
S
S
F
F
E
E
F
G
K
Site 57
S562
R
E
A
D
E
M
D
S
I
H
D
V
T
F
Q
Site 58
T567
M
D
S
I
H
D
V
T
F
Q
V
G
N
R
L
Site 59
Y580
R
L
F
P
A
H
K
Y
I
L
A
V
H
S
D
Site 60
S595
F
F
Q
K
L
F
L
S
D
G
N
T
S
E
F
Site 61
T599
L
F
L
S
D
G
N
T
S
E
F
T
D
I
Y
Site 62
Y606
T
S
E
F
T
D
I
Y
Q
K
D
E
D
S
A
Site 63
Y630
V
H
P
D
M
F
E
Y
L
L
Q
F
I
Y
T
Site 64
T644
T
D
T
C
D
F
L
T
H
G
F
K
P
R
I
Site 65
T663
N
P
E
E
Y
Q
G
T
L
N
S
H
L
N
K
Site 66
S688
S
A
F
E
V
Y
K
S
N
Q
A
Q
T
V
S
Site 67
S695
S
N
Q
A
Q
T
V
S
E
R
Q
K
S
K
P
Site 68
S700
T
V
S
E
R
Q
K
S
K
P
K
S
C
K
K
Site 69
S704
R
Q
K
S
K
P
K
S
C
K
K
G
K
N
I
Site 70
T722
D
P
V
R
M
L
Q
T
V
A
K
K
F
D
F
Site 71
S730
V
A
K
K
F
D
F
S
N
L
S
S
R
L
D
Site 72
S733
K
F
D
F
S
N
L
S
S
R
L
D
G
V
R
Site 73
S734
F
D
F
S
N
L
S
S
R
L
D
G
V
R
F
Site 74
S760
T
G
N
K
L
K
L
S
Q
K
K
C
S
F
L
Site 75
S765
K
L
S
Q
K
K
C
S
F
L
C
D
V
T
M
Site 76
S774
L
C
D
V
T
M
K
S
V
D
G
K
E
F
P
Site 77
S796
A
R
L
E
Y
F
H
S
M
L
S
S
S
W
I
Site 78
S799
E
Y
F
H
S
M
L
S
S
S
W
I
E
A
S
Site 79
S800
Y
F
H
S
M
L
S
S
S
W
I
E
A
S
S
Site 80
S801
F
H
S
M
L
S
S
S
W
I
E
A
S
S
C
Site 81
S924
D
G
V
L
K
D
L
S
E
F
Y
R
K
M
I
Site 82
T940
A
M
D
R
R
V
I
T
P
Y
Q
D
G
P
D
Site 83
Y942
D
R
R
V
I
T
P
Y
Q
D
G
P
D
I
S
Site 84
S949
Y
Q
D
G
P
D
I
S
Y
L
E
V
E
D
G
Site 85
Y950
Q
D
G
P
D
I
S
Y
L
E
V
E
D
G
D
Site 86
S990
K
K
K
P
R
K
R
S
D
S
S
G
G
Y
N
Site 87
S992
K
P
R
K
R
S
D
S
S
G
G
Y
N
L
S
Site 88
S993
P
R
K
R
S
D
S
S
G
G
Y
N
L
S
D
Site 89
Y996
R
S
D
S
S
G
G
Y
N
L
S
D
I
I
Q
Site 90
S999
S
S
G
G
Y
N
L
S
D
I
I
Q
S
P
S
Site 91
S1004
N
L
S
D
I
I
Q
S
P
S
S
T
G
L
L
Site 92
S1006
S
D
I
I
Q
S
P
S
S
T
G
L
L
K
S
Site 93
S1007
D
I
I
Q
S
P
S
S
T
G
L
L
K
S
G
Site 94
T1008
I
I
Q
S
P
S
S
T
G
L
L
K
S
G
K
Site 95
S1013
S
S
T
G
L
L
K
S
G
K
T
N
S
V
E
Site 96
T1016
G
L
L
K
S
G
K
T
N
S
V
E
S
L
P
Site 97
S1018
L
K
S
G
K
T
N
S
V
E
S
L
P
E
L
Site 98
S1021
G
K
T
N
S
V
E
S
L
P
E
L
L
T
S
Site 99
T1027
E
S
L
P
E
L
L
T
S
D
S
E
G
S
Y
Site 100
S1028
S
L
P
E
L
L
T
S
D
S
E
G
S
Y
A
Site 101
S1030
P
E
L
L
T
S
D
S
E
G
S
Y
A
G
V
Site 102
S1033
L
T
S
D
S
E
G
S
Y
A
G
V
G
S
P
Site 103
Y1034
T
S
D
S
E
G
S
Y
A
G
V
G
S
P
R
Site 104
S1039
G
S
Y
A
G
V
G
S
P
R
D
L
Q
S
P
Site 105
S1045
G
S
P
R
D
L
Q
S
P
D
F
T
T
G
F
Site 106
T1049
D
L
Q
S
P
D
F
T
T
G
F
H
S
D
K
Site 107
T1050
L
Q
S
P
D
F
T
T
G
F
H
S
D
K
I
Site 108
S1054
D
F
T
T
G
F
H
S
D
K
I
E
A
K
V
Site 109
Y1064
I
E
A
K
V
K
P
Y
V
N
G
T
S
P
V
Site 110
T1068
V
K
P
Y
V
N
G
T
S
P
V
Y
S
R
E
Site 111
S1069
K
P
Y
V
N
G
T
S
P
V
Y
S
R
E
D
Site 112
Y1072
V
N
G
T
S
P
V
Y
S
R
E
D
L
K
P
Site 113
S1073
N
G
T
S
P
V
Y
S
R
E
D
L
K
P
W
Site 114
S1083
D
L
K
P
W
E
K
S
P
I
L
K
I
S
A
Site 115
S1089
K
S
P
I
L
K
I
S
A
P
Q
P
I
P
S
Site 116
S1096
S
A
P
Q
P
I
P
S
N
R
I
D
T
T
S
Site 117
T1101
I
P
S
N
R
I
D
T
T
S
S
A
S
W
V
Site 118
T1102
P
S
N
R
I
D
T
T
S
S
A
S
W
V
A
Site 119
S1103
S
N
R
I
D
T
T
S
S
A
S
W
V
A
G
Site 120
S1104
N
R
I
D
T
T
S
S
A
S
W
V
A
G
S
Site 121
S1111
S
A
S
W
V
A
G
S
F
S
P
V
S
P
P
Site 122
S1113
S
W
V
A
G
S
F
S
P
V
S
P
P
V
V
Site 123
S1116
A
G
S
F
S
P
V
S
P
P
V
V
D
L
R
Site 124
T1124
P
P
V
V
D
L
R
T
I
M
E
I
E
E
S
Site 125
S1131
T
I
M
E
I
E
E
S
R
Q
K
C
G
A
T
Site 126
T1138
S
R
Q
K
C
G
A
T
P
K
S
H
L
G
K
Site 127
S1141
K
C
G
A
T
P
K
S
H
L
G
K
T
V
S
Site 128
T1146
P
K
S
H
L
G
K
T
V
S
H
G
V
K
L
Site 129
S1148
S
H
L
G
K
T
V
S
H
G
V
K
L
S
Q
Site 130
S1154
V
S
H
G
V
K
L
S
Q
K
Q
R
K
M
I
Site 131
S1170
L
T
T
K
E
N
N
S
G
M
N
S
M
E
T
Site 132
S1174
E
N
N
S
G
M
N
S
M
E
T
V
L
F
T
Site 133
T1177
S
G
M
N
S
M
E
T
V
L
F
T
P
S
K
Site 134
T1181
S
M
E
T
V
L
F
T
P
S
K
A
P
K
P
Site 135
S1183
E
T
V
L
F
T
P
S
K
A
P
K
P
V
N
Site 136
S1194
K
P
V
N
A
W
A
S
S
L
H
S
V
S
S
Site 137
S1195
P
V
N
A
W
A
S
S
L
H
S
V
S
S
K
Site 138
S1198
A
W
A
S
S
L
H
S
V
S
S
K
S
F
R
Site 139
S1200
A
S
S
L
H
S
V
S
S
K
S
F
R
D
F
Site 140
S1201
S
S
L
H
S
V
S
S
K
S
F
R
D
F
L
Site 141
S1203
L
H
S
V
S
S
K
S
F
R
D
F
L
L
E
Site 142
S1214
F
L
L
E
E
K
K
S
V
T
S
H
S
S
G
Site 143
T1216
L
E
E
K
K
S
V
T
S
H
S
S
G
D
H
Site 144
S1217
E
E
K
K
S
V
T
S
H
S
S
G
D
H
V
Site 145
S1219
K
K
S
V
T
S
H
S
S
G
D
H
V
K
K
Site 146
S1228
G
D
H
V
K
K
V
S
F
K
G
I
E
N
S
Site 147
S1235
S
F
K
G
I
E
N
S
Q
A
P
K
I
V
R
Site 148
S1244
A
P
K
I
V
R
C
S
T
H
G
T
P
G
P
Site 149
T1245
P
K
I
V
R
C
S
T
H
G
T
P
G
P
E
Site 150
T1248
V
R
C
S
T
H
G
T
P
G
P
E
G
N
H
Site 151
S1257
G
P
E
G
N
H
I
S
D
L
P
L
L
D
S
Site 152
S1264
S
D
L
P
L
L
D
S
P
N
P
W
L
S
S
Site 153
S1270
D
S
P
N
P
W
L
S
S
S
V
T
A
P
S
Site 154
S1271
S
P
N
P
W
L
S
S
S
V
T
A
P
S
M
Site 155
S1272
P
N
P
W
L
S
S
S
V
T
A
P
S
M
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation